[Rosiglitazone ameliorates TNBS-induced colitis in mice by inhibiting inflammation of the mesenteric adipose tissues].

Objective To evaluate the therapeutic effect and possible mechanism of PPARγ agonist rosiglitazone on 2, 4, 6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in mice. Methods Twenty male BALB/c mice were selected to establish TNBS-induced colitis model and were randomly divided into rosiglitazone treated group and model group with 10 rats in each group. Rosiglitazone group was treated with rosiglitazone(0.

[IL-12 monoclonal antibody alleviates intestinal inflammation in IL-10 mice by regulating intestinal mucosal immunity].

Objective To evaluate the therapeutic effect and possible mechanism of IL-12 monoclonal antibody (IL-12 mAb) on IL-10 knockout(IL-10) mice and its possible mechanism. Methods Sixteen male IL-10 mice of 15 weeks old were randomly divided into control group and IL-12 mAb treatment group. The IL-12 mAb treatment group were given intraperitoneal injection of IL-12 mAb (25 mg/kg, once per week), and the control group was given intraperitoneal injection of 0.