735 results match your criteria: "Medical Imaging Research Center[Affiliation]"

Hydatid cysts, caused by the parasite, predominantly affect the liver and lungs, but can also impact other organs such as the kidneys, brain, and muscles. Infection occurs when individuals ingest eggs from contaminated food or water, leading to cyst formation primarily in the liver. While hydatid cysts are commonly found in various endemic regions, muscular involvement is rare, particularly in the psoas muscle.

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Drug repositioning for Parkinson's disease: An emphasis on artificial intelligence approaches.

Ageing Res Rev

January 2025

Center for Global Health Research, Saveetha Medical College & Hospitals, Saveetha Institute of Medical & Technical Sciences, Saveetha University, Chennai, India; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Parkinson's disease (PD) is one of the most incapacitating neurodegenerative diseases (NDDs). PD is the second most common NDD worldwide which affects approximately 1-2 percent of people over 65 years. It is an attractive pursuit for artificial intelligence (AI) to contribute to and evolve PD treatments through drug repositioning by repurposing existing drugs, shelved drugs, or even candidates that do not meet the criteria for clinical trials.

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Analysis and prediction of condylar resorption following orthognathic surgery.

Sci Rep

January 2025

OMFS IMPATH Research Group, Department of Imaging and Pathology, Faculty of Medicine, KU Leuven, Leuven, Belgium.

Condylar resorption is a feared complication of orthognathic surgery. This study investigated condylar resorption in a cohort of 200 patients This allowed for a powerful update on incidence and risk factors. 9.

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Article Synopsis
  • The review investigates the unclear relationship between insulin resistance and bone mineral density (BMD), aiming to identify associations using various insulin resistance indices.
  • A systematic review of 27 studies involving over 71,000 participants was conducted, highlighting that indices like HOMA-IR showed no significant link to BMD, while a higher TyG index was generally associated with lower BMD levels.
  • The findings indicate a complex relationship requiring more longitudinal studies for robust conclusions, as the inability to conduct a meta-analysis limits the current results' strength.
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Introduction: The persistent sciatic artery (PSA) is a rare congenital vascular anomaly that arises when the embryonic axial artery fails to regress, potentially leading to serious complications such as limb ischemia.

Case Presentation: We report the case of a 47-year-old woman with a history of essential hypertension and recent hormonal treatment for uterine fibroids. She developed acute limb ischemia due to bilateral PSA thrombosis, which was confirmed through comprehensive imaging.

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Aspergillus-related immune reconstitution inflammatory syndrome (IRIS) is a challenge to diagnose in immunocompromised pediatric cancer patients with Invasive Pulmonary Aspergillosis (IPA). If not recognized, it can mimic disease progression and lead to overtreatment. Studies on Aspergillus-related IRIS in the pediatric population are scarce.

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Background: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease in human history and it is expected to surpass other causes of liver disease mortality by 2030. Therefore, finding an alternative way to diagnose steatosis in the early stage when imaging modalities are not available is crucial. This study decided to validate the optimal cut-off points and the sensitivity and specificity of the Fatty Liver Index (FLI) based on the Iranian population compared to ultrasonography.

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Human craniofacial shape is highly variable yet highly heritable with numerous genetic variants interacting through multiple layers of development. Here, we hypothesize that Mendelian phenotypes represent the extremes of a phenotypic spectrum and, using achondroplasia as an example, we introduce a syndrome-informed phenotyping approach to identify genomic loci associated with achondroplasia-like facial variation in the general population. We compare three-dimensional facial scans from 43 individuals with achondroplasia and 8246 controls to calculate achondroplasia-like facial scores.

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Mapping genes for human face shape: Exploration of univariate phenotyping strategies.

PLoS Comput Biol

December 2024

Department of Electrical Engineering, ESAT/PSI, KU Leuven, Leuven, Belgium.

Human facial shape, while strongly heritable, involves both genetic and structural complexity, necessitating precise phenotyping for accurate assessment. Common phenotyping strategies include simplifying 3D facial features into univariate traits such as anthropometric measurements (e.g.

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The efficacy of opportunistic osteoporosis screening with computed tomography (CT) scans obtained for other indications has not yet been implemented by the current guidelines. We aimed to compile available evidence on the efficacy of osteoporosis screening with CT scans obtained for other indications compared with dual X-ray absorptiometry (DXA). Studies comparing the diagnostic performance of the CT scan with the DXA published before 2023 were retrieved.

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Purpose: Solutions of iodine-based compounds, due to their high X-ray attenuation coefficient, are widely used as contrast agents in computed tomography (CT) imaging. This paper investigates the attenuation properties of iodine and gold to develop nanoparticle-based contrast agents, for example, composite nanoparticles (NPs) with layers of iodine and gold or a mixture of NPs of gold and iodine.

Materials And Methods: A theoretical formula is derived that gives the Hounsfield Unit (HU) for different weight-by-weight (w/w) concentrations of a mixture of blood + iodine + gold.

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Carotid intima media thickness and glomerular filtration rate: a baseline analysis of the PolyIran-L trial.

J Nephrol

November 2024

MD-MPH Department, School of Medicine, Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: The relationship between kidney and vascular health is acknowledged, but detailed information is still missing. This study examines the relationship of estimated glomerular filtration rate (eGFR) and carotid intima media thickness, providing insights into the association between atherosclerosis and kidney function.

Methods: Participants older than 50 years of age who were part of the PolyIran-L study, a trial nested in the Golestan Cohort Study, were included.

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Article Synopsis
  • The study explores the use of a deep-learning network to correct motion blur in myocardial perfusion imaging (MPI) with SPECT, aiming to improve the detection of perfusion defects.
  • Researchers trained the network on 197 ECG-gated SPECT-MPI images and tested its effectiveness on a separate dataset of 194 subjects with simulated lesions, analyzing results through receiver-operating characteristic (ROC) curves.
  • Results indicated that deep-learning motion correction significantly enhances detectability of perfusion defects, achieving higher accuracy in specific cardiac phases versus traditional ungated studies, especially in reduced-count scenarios.
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Implementing verifiable oncological imaging by quality assurance and optimization (i‑Violin) : Protocol for a European multicenter study.

Radiologie (Heidelb)

November 2024

Institute of Medical Technology, Faculty for electrical engineering and Information Technology, Otto-von-Guericke-University Magdeburg, Otto-Hahn-Str. 2, 39106, Magdeburg, Germany.

Background: Advanced imaging techniques play a pivotal role in oncology. A large variety of computed tomography (CT) scanners, scan protocols, and acquisition techniques have led to a wide range in image quality and radiation exposure. This study aims at implementing verifiable oncological imaging by quality assurance and optimization (i-Violin) through harmonizing image quality and radiation dose across Europe.

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Efficacy and safety of apraglutide in short bowel syndrome with intestinal failure and colon-in-continuity: A multicenter, open-label, metabolic balance study.

Clin Nutr

December 2024

Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium; Leuven Intestinal Failure and Transplantation Center (LIFT), University Hospitals Leuven, Leuven, Belgium. Electronic address:

Article Synopsis
  • Apraglutide is a new long-acting GLP-2 analog being tested for short bowel syndrome with intestinal failure (SBS-IF) in a phase 2 study.
  • The study involved 9 adult patients receiving weekly injections of apraglutide over 52 weeks, measuring its safety and effects on their nutritional needs and intestinal health.
  • Results showed significant improvements, including a 52% decrease in parenteral support needs and enhanced absorption of nutrients, alongside a manageable safety profile with mostly mild adverse events.
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Quantitative analysis of facial shape in children to support respirator design.

Appl Ergon

January 2025

Department of Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada; Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada; McCaig Bone and Joint Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. Electronic address:

The COVID-19 pandemic demonstrated the need for respiratory protection against airborne pathogens. Respirator options for children are limited, and existing designs do not consider differences in facial shape or size. We created a dataset of children's facial images from three cohorts, then used geometric morphometric analyses of dense and sparse facial landmark representations to quantify age, sex and ancestry-related variation in shape.

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Unsupervised learning, particularly clustering, plays a pivotal role in disease subtyping and patient stratification, especially with the abundance of large-scale multi-omics data. Deep learning models, such as variational autoencoders (VAEs), can enhance clustering algorithms by leveraging inter-individual heterogeneity. However, the impact of confounders-external factors unrelated to the condition, e.

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Background: The two classic manifestations of primary aldosteronism are hypertension and hypokalemia. However, acute respiratory failure due to hypokalemia in primary hyperaldosteronism is rare.

Case Presentation: The patient was a 27-year-old female who presented with drowsiness and weakness in all extremities.

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Article Synopsis
  • AI has the potential to improve gastrointestinal endoscopy, but standardized methods are needed for its effective adoption in clinical practice.
  • The QUAIDE Explanation and Checklist was created by a panel of 32 experts to provide guidelines for designing and reporting AI studies in this field.
  • Consensus was achieved on 18 recommendations across key areas including data collection, outcome reporting, experimental setup, and result presentation, aiming to enhance research consistency and facilitate the use of AI in clinical settings.
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Article Synopsis
  • Virtual reality (VR) and augmented reality (AR) have greatly improved cardiac preoperative planning, though there's a lack of a comprehensive mixed reality application for use in team meetings.
  • A new multi-user, multi-device mixed reality application was developed and validated through technical tests, preclinical evaluations by cardiology experts, and clinical assessments on five patients comparing VR measurements with traditional CT scans.
  • Results showed that the application achieved precise measurements with a median error of 0.69 mm and was user-friendly, but further research is required to confirm its broader effectiveness and impact on patient care.
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Structural and transcriptional signatures of arithmetic abilities in children.

NPJ Sci Learn

September 2024

Beijing Key Laboratory of Applied Experimental Psychology, National Demonstration Center for Experimental Psychology Education (Beijing Normal University), Faculty of Psychology, Beijing Normal University, Beijing, China.

Arithmetic ability is critical for daily life, academic achievement, career development, and future economic success. Individual differences in arithmetic skills among children and adolescents are related to variations in brain structures. Most existing studies have used hypothesis-driven region of interest analysis.

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Automated cardiac coverage assessment in cardiovascular magnetic resonance imaging using an explainable recurrent 3D dual-domain convolutional network.

Med Phys

December 2024

Christable Pankhurst Institute, Division of Informatics, Imaging and Data Sciences, School of Health Sciences, and Department of Computer Science, School of Engineering, The University of Manchester, Manchester, UK.

Background: Cardiovascular magnetic resonance (CMR) imaging has become a modality with superior power for the diagnosis and prognosis of cardiovascular diseases. One of the essential quality controls of CMR images is to investigate the complete cardiac coverage, which is necessary for the volumetric and functional assessment.

Purpose: This study examines the full cardiac coverage using a 3D dual-domain convolutional model and then improves this model using an innovative explainable salient region detection model and a recurrent architecture.

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The impact of breastfeeding on facial appearance in adolescent children.

PLoS One

September 2024

Department of Oral and Craniofacial Sciences, Center for Craniofacial and Dental Genetics, University of Pittsburgh, Pittsburgh, PA, United States of America.

Evidence that breastfeeding impacts the facial features of children is conflicting. Most studies to date have focused on dental and skeletal malocclusion. It currently remains unclear whether such effects are of sufficient magnitude to be detectable on outward facial appearance.

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Intramural gastric pseudocysts are extremely rare and are often associated with pancreatitis and pancreatic pseudocysts; they can lead to complex clinical presentations requiring careful diagnosis and management. We present a case of a 57-year-old man with a history of pancreatitis and pancreatic pseudocysts who was diagnosed with intramural gastric pseudocysts. The patient was diagnosed with multiple gastric intramural pseudocysts at different locations during separate admissions and imaging studies.

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