Kinetic analysis of D-Alanine upon oral intake in humans.

D-Alanine, a rare enantiomer of alanine, can potentially alleviate the worsening of viral infections and maintain circadian rhythm. This study aimed to analyze the kinetics of D-Alanine upon oral intake. Five healthy volunteers were administered D-Alanine as a single oral dose at 11,236 or 33,708 µmoL (1-3 g).

Evaluation of the clinical efficacy of Zhuanggu Zhitong Recipe in treatment of postmenopausal osteoporosis and its correlation with the AMPK/mTOR autophagy signaling pathway.

Objective: To evaluate the efficacy of bone strengthening and pain relieving capsules in the treatment of postmenopausal osteoporosis and its correlation with AMPK/mTOR autophagy signaling pathway.

Methods: Between January 2021 and December 2022, 100 patients with postmenopausal osteoporosis of liver-kidney yin deficiency and qi stagnation and blood stasis type were retrospectively screened in the outpatient and inpatient departments of the Department of Orthopaedics and Traumatology of Liuzhou Hospital of Traditional Chinese Medicine, Guangxi Zhuang Autonomous Region, and were randomly divided into 2 groups of 50 patients each according to the order of the timing of the consultation, namely, the Strong Bone Pain Relief Capsules Treatment Group and the Alendronate Sodium Control Group. Bone mineral density of the left femur, Chinese medicine evidence points, serum AMPK level, E2 level before and after treatment, Ca level, IL-17, serum phosphorus level, ALP, PTH, OC, PINP, NTX and TRAP-5b level before and after drug intervention were detected in the two groups.

Psychological changes among weight loss injection users compared with bariatric surgery patients in Saudi Arabia.

Objectives: To assess and evaluate the mental health and psychological changes in weight loss injection users and bariatric surgery.

Methods: A descriptive and analytical cross-sectional study was conducted from July 2022 to December 2022. A self-administered questionnaire was given among participants using social media platforms.

The prognostic value of skeletal muscle mass and density in breast cancer: a systematic review and meta-analysis.

The effect of skeletal muscle mass and density on the long-term survival outcome of breast cancer patients is unclear. Systematically searched all articles in PubMed, Web of science, Springerlink, EMBASE and Wiley databases that studied the association between skeletal muscle and survival outcomes of breast cancer by 25 September 2023. The hazard ratios and confidence intervals of the multiple factor analysis results controlling for confounding variables in the study were collected and analyzed using STATA 14.

Quercetin Promotes the M1-to-M2 Macrophage Phenotypic Switch During Liver Fibrosis Treatment by Modulating the JAK2/STAT3 Signaling Pathway.

Objective: To investigate the underlying mechanism by which quercetin (Que) regulates macrophage polarization and its subsequent therapeutic effect on liver fibrosis, an important pathological precondition for hepatocellular carcinoma (HCC).

Methods: In vitro experiments were performed on the RAW264.7 mouse macrophage line.

[Survey of Preventing Exposure Regarding Sweat in Patients Receiving Antineoplastic Agents at Base Hospitals for Promoting Hematopoietic Stem Cell].

This survey aimed to reveal the actual preventing exposure for handling of clothing and sweat of patients treated with anticancer drugs, following the publication of "Guideline for Preventing Occupational Exposure in Cancer Chemotherapy Drugs, 2019 Edition" (Guideline 2019). A survey was conducted among nurses working at 95 hematopoietic stem cell transplantation promotion base hospitals from September 1, 2023 to October 31, 2023. The response rate was 84.

Efficiency of Oral Steroids and Steroidal Nasal Spray in Treatment of Chronic Rhinosinusitis: A Comparative Study.

Objective: To assess how well steroidal nasal sprays and oral steroids work for treating CRS.

Methods: Two hundred patients with CRS were included in a randomized controlled experiment. The patients were split into two groups: Group B received steroidal nasal sprays (fluticasone propionate 110 mcg/day in each nostril for 12 weeks) and Group A received oral steroids (prednisolone 30 mg/day for 14 days, followed by tapering over 7 days).

Prognostic Significance of Albumin-Globulin Ratio in Urachal Carcinoma.

Introduction: Although albumin-globulin ratio (AGR) has been used in the prognostic assessment of multiple solid malignancies, so far no research has confirmed the prognostic significance of AGR as a biomarker for urachal carcinoma. We analyzed the relationship between AGR and prognosis in urachal carcinoma, aiming to identify a promising prognostic biomarker for urachal carcinoma.

Methods: We reviewed the clinical data of 25 patients diagnosed with urachal carcinoma in the Xiangya Hospital, Central South University, from January 2008 to October 2021.

Hsa_circ_0079929 in lung adenocarcinoma and its biological implications in lung adenocarcinoma progression.

Background: This report investigated the expression, prognostic and biological implications of hsa_circ_0079929 in lung adenocarcinoma, which was based on clinical and experimental data.

Methods: Patients with lung adenocarcinoma were screened and their clinical data and tissues (including cancerous tissues and adjacent normal tissues) were collected. The total RNA in tissues and cell lines was analyzed to obtained hsa_circ_0079929 level.

A Multidisciplinary Approach in the Management of Infectious Diarrhea in the Emergency Department.

Background Globally, infectious diarrhea poses a serious threat to public health, especially in emergency department (ED) settings where timely and efficient treatment is essential. The primary objective of this study was to explore and evaluate the efficacy of a multidisciplinary approach (MDA) in the management of infectious diarrhea within the ED setting. Methodology This prospective cohort study was conducted from January to December 2023 at the Lady Reading Hospital ED in Peshawar, Pakistan.

Consider or not consider: the unsolved question on the use of radioactive iodine for differentiated thyroid cancer with low to intermediate risk of recurrence.

Background: Surgery stands as the cornerstone treatment for differentiated thyroid cancer (DTC). After surgery, radioactive iodine (RAI) administration is primarily recommended for high-risk patients and commonly employed to address residual disease or mitigate the risk of recurrence. However, the optimal application of RAI in cases categorized as low to intermediate risk is still uncertain.

Typing of Vulvar Squamous Cell Carcinoma: Why it is Important?

The classification of vulvar squamous cell carcinoma (VSCC), as in endometrial cancer, has shifted from the histology-based descriptors toward molecular-based identifiers. Recently, it has been reported that there are 3 genetically distinct and clinically significant subtypes of VSCC: HPV-associated VSCC, HPV-independent/p53 wild-type VSCC, and HPV-independent/p53-mutated VSCC. Each group has different prognostic implications as well as response to treatment, thus reinforcing the need for this 3-tier molecular classification.

Diagnostic Efficacy of Ultrasound-Based International Ovarian Tumor Analysis Simple Rules and Assessment of the Different Neoplasias in the Adnexa Model in Malignancy Prediction Among Women With Adnexal Masses: A Systematic Review.

Transvaginal ultrasonography (USG) is most commonly used before surgery to accurately diagnose benign and malignant ovarian masses for effective treatment, avoid unnecessary interventions, improve the prognosis of patients, and preserve fertility in patients with benign tumors. Therefore, the objective of the present systematic review was to assess the diagnostic efficacy of ultrasound-based International Ovarian Tumor Analysis (IOTA) Simple Rules (SR) and Assessment of Different NEoplasias in the adneXa (ADNEX) model in predicting malignancy among women with adnexal masses. A systematic literature search was carried out on electronic databases consisting of Science Direct, PubMed, and Google Scholar.

Smoking is a predominant risk factor for coronary artery disease among Indians.

Smoking has emerged as a predominant risk factor for coronary artery disease (CAD) in India, contributing significantly to the country's rising cardiovascular morbidity and mortality rates. The adverse effects of tobacco on cardiovascular health are well-documented, exacerbating a public health challenge in a nation with a high prevalence of smoking. Therefore, it is of interest to analyse the impact of smoking on the incidence and progression of coronary artery disease among the Indian population, emphasizing the need for targeted public health interventions to mitigate this risk factor.

CD10 Immunohistochemical Expression in Breast Carcinoma and Its Correlation With Clinicopathological Parameters.

Background:  Interaction between the stromal and tumor cells is of crucial importance in breast cancer progression and response to therapy. A literature search has shown that stromal CD10 expression signifies the biological aggressiveness of various epithelial malignancies. Stromal markers are now becoming apparent as novel markers in evaluating the prognosis of invasive breast cancer and have not been studied substantially to date.

Two-Step Operation for Aortoesophageal Fistula After Thoracic Endovascular Repair.

Aortoesophageal fistula (AEF) caused after thoracic endovascular aortic repair (TEVAR) is rare but a serious complication. We report a successful staged operation for AEF after TEVAR. A 70-year-old male underwent TEVAR for a ruptured aneurysm of the descending aorta and subsequently developed AEF three months later.

Assessing the Impact of Hematological Changes in Pregnancy on Maternal and Fetal Death: A Narrative Review.

Hematological changes during pregnancy encompass a wide range of alterations in blood composition and function, including variations in hemoglobin levels, red blood cell count, and coagulation factors. These changes can be physiological or pathological and may significantly impact maternal and fetal health outcomes. This narrative review examines the relationship between various hematological changes and disorders during pregnancy and their effects on maternal and fetal mortality and morbidity.

First‑line endocrine therapy for hormone receptor positive and HER‑2 negative metastatic breast cancer: A Bayesian network meta‑analysis.

Endocrine therapy has become the fundamental treatment option for hormone receptor-positive (HR) and receptor tyrosine-protein kinase erbB-2-negative (HER2) metastatic breast cancer (mBC). While treatments incorporating cyclin-dependent kinase (CDK)4 and 6 inhibitors are more prevalent than ever, comparisons among those regimens are scarce. The aim of the present study was to identify the most effective maintenance treatment for patients with HR and HER2 mBC.

Autospreader Flaps in Closed Rhinoplasty: Our Technique and Long-Term Results.

Introduction:  Rhinoplasty is a common and complex surgical procedure. Respiratory and aesthetic dissatisfaction are major causes of revision surgeries. Multiple techniques were described to reconstruct the middle nasal vault and improve functional outcomes.