3 results match your criteria: "Medical Faculty of Charles University in Hradec Kralove and University Hospital Hradec Kralove[Affiliation]"
Proteomic Profiling of Dilated Cardiomyopathy Plasma Samples ─ Searching for Biomarkers with Potential to Predict the Outcome of Therapy.
J Proteome Res
March 2024
The first Department of Internal Medicine - Cardioangiology, Medical Faculty of Charles University in Hradec Kralove and University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 50005, Czech Republic.
Determination of the prognosis and treatment outcomes of dilated cardiomyopathy is a serious problem due to the lack of valid specific protein markers. Using in-depth proteome discovery analysis, we compared 49 plasma samples from patients suffering from dilated cardiomyopathy with plasma samples from their healthy counterparts. In total, we identified 97 proteins exhibiting statistically significant dysregulation in diseased plasma samples.
View Article and Find Full Text PDFEffects of Hypothermia vs Normothermia on Societal Participation and Cognitive Function at 6 Months in Survivors After Out-of-Hospital Cardiac Arrest: A Predefined Analysis of the TTM2 Randomized Clinical Trial.
JAMA Neurol
October 2023
Neurology, Department of Clinical Sciences Lund, Lund University, Skane University Hospital, Lund, Sweden.
Article Synopsis
- The TTM2 trial found no significant difference in mortality or poor functional outcomes between targeted hypothermia and targeted normothermia 6 months after out-of-hospital cardiac arrest (OHCA).
- A detailed analysis aimed to assess brain dysfunction and cognitive function in survivors, focusing on societal participation after OHCA.
- This study involved 1861 comatose adults across 61 hospitals in 14 countries, with follow-up conducted by masked assessors showing no differences in functional outcomes between the two temperature control methods.
No significant retinal damage induced by major orthopedic surgery - a pilot study.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
May 2022
Department of Anesthesiology, Perioperative Medicine and Intensive Care, J.E. Purkinje University, Masaryk Hospital Usti nad Labem, Socialni pece 3316/12A, Usti nad Labem 400 11, Czech Republic.
Background: Perioperative visual loss is one of the rare but devastating complications of anesthesia and surgery. The incidence of less severe or even subclinical postoperative visual dysfunction is unknown. Therefore, we decided to perform a pilot prospective observational clinical study to evaluate whether structural changes of the retina can be detected in patients undergoing elective orthopaedic surgery by optical coherence tomography (OCT).
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