Early and minimal changes in serum creatinine can predict prognosis in elderly patients receiving invasive mechanical ventilation: A retrospective observational study.

Background: Emerging evidence suggests that minimal acute kidney injury (stage 1 AKI) is associated with increased hospital mortality rates. However, for those who do not meet the AKI diagnostic criteria, whether a small increase in serum creatinine (SCr) levels is associated with an increased mortality rate in elderly patients is not known. Therefore, we aimed to investigate small elevations in SCr of <26.

Prediction of sepsis among patients with major trauma using artificial intelligence: a multicenter validated cohort study.

Background: Sepsis remains a significant challenge in patients with major trauma in the ICU. Early detection and treatment are crucial for improving outcomes and reducing mortality rates. Nonetheless, clinical tools for predicting sepsis among patients with major trauma are limited.

First/second-order predefined-time convergent ZNN models for time-varying quadratic programming and robotic manipulator application.

Zeroing neural network (ZNN) model, an important class of recurrent neural network, has been widely applied in the field of computation and optimization. In this paper, two ZNN models with predefined-time convergence are proposed for the time-varying quadratic programming (TVQP) problem. First, in the framework of the traditional ZNN model, the first-order predefined-time convergent ZNN (FPTZNN) model is proposed in combination with a predefined-time controller.

Acute lung injury caused by sepsis: how does it happen?

Sepsis is a systemic inflammatory disease caused by severe infections that involves multiple systemic organs, among which the lung is the most susceptible, leaving patients highly vulnerable to acute lung injury (ALI). Refractory hypoxemia and respiratory distress are classic clinical symptoms of ALI caused by sepsis, which has a mortality rate of 40%. Despite the extensive research on the mechanisms of ALI caused by sepsis, the exact pathological process is not fully understood.

The duration of acute kidney injury is an additional parameter to predict 1-year survival in very elderly patients.

Background: Acute kidney injury (AKI) is primarily defined and classified according to the magnitude of the elevation of serum creatinine (Scr). We aimed to determine whether the duration of AKI adds prognostic value in addition to that obtained from the magnitude of injury alone.

Methods: This retrospective study enrolled very elderly inpatients (≥75 years) in the Chinese PLA General Hospital from January 2007 to December 2018.