1 results match your criteria: "Medical College of Wisconsin 8727 Watertown Plank Rd[Affiliation]"
Cytoprotective membrane-permeable peptides designed from the Bax-binding domain of Ku70.
Nat Cell Biol
April 2003
Blood Research Institute, The Blood Center of South Eastern Wisconsin and Department of Biochemistry, Medical College of Wisconsin 8727 Watertown Plank Rd, Milwaukee WI 53226, USA.
Article Synopsis
- Bax is a pro-apoptotic protein that normally stays in the cytosol but moves to mitochondria when apoptosis is triggered.
- Ku70, a protein involved in DNA repair, interacts with Bax in the cytosol, preventing its movement to mitochondria and thereby inhibiting apoptosis.
- A new peptide called Bax-inhibiting peptide (BIP) was developed to block Bax's translocation and has shown promise in reducing apoptosis in response to various stimuli, potentially aiding in treatment strategies for apoptosis-related diseases.