16,033 results match your criteria: "Medical College of Georgia[Affiliation]"

Article Synopsis
  • Ischemic stroke can lead to severe disability and death, and researchers are investigating how the timing of a stroke impacts its severity, particularly focusing on the circadian clock protein Rev-Erbα.
  • A study found that administering SR9009, a Rev-Erbα agonist, significantly reduced neuroinflammation and infarct size in mice when treated at specific times (ZT06 - during sleep) but not at other times (ZT18 - during wakefulness).
  • The results suggest that SR9009 alters immune responses and may offer therapeutic benefits for stroke treatment, emphasizing the importance of timing in administering interventions.
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Exploring New Links Among Keratoconus, Hormonal Factors, and Medications: Insights From a Case-Control Study Utilizing the All of Us Database.

Transl Vis Sci Technol

November 2024

Department of Cellular Biology and Anatomy, Center for Biotechnology and Genomic Medicine, James and Jean Culver Vision Discovery Institute, Augusta University, Augusta, GA, USA.

Article Synopsis
  • The study aimed to identify clinical factors linked to keratoconus (KC) risk using data from the All of Us Research Program, examining 572 KC patients matched with 1716 controls.
  • Key findings revealed that ocular surface disease and obesity had the strongest positive correlations with KC, while smoking was negatively correlated.
  • The research highlights that increased exposure to estrogen and tetracycline medications are new risk factors for KC, emphasizing the importance of recognizing these for early diagnosis and interventions.
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There is growing concern over the safety of artificial turf when it comes to the incidence of player injuries. The artificial surfaces can withstand more play, are cheaper to maintain, and are more predictable. However, there is concern that this beneficial durability comes at the expense of the forgiveness of the surface, leading to more injuries.

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Cardiovascular Risk Assessment and Prevention in Cardio-Oncology: Beyond Traditional Risk Factors.

Cardiol Clin

February 2025

Department of Medicine, Cardio-Oncology Program, Cardiology Division, Medical College of Georgia at Augusta University, Augusta, GA, USA; Division of Cardiology, Department of Medicine, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA. Electronic address:

This review goes beyond traditional approaches in cardio-oncology, highlighting often-neglected factors impacting patient care. Social determinants, environment, health care access, and gut microbiome significantly influence patient outcomes. Powerful tools like multi-omics and wearable technologies offer deeper insights into real-world experiences.

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Objectives: To present the clinical results obtained using a novel coded healing abutment (CHA).

Methods: We evaluated 103 patients with fixed implant-supported zirconia restorations (90 single crowns, 26 partial dentures, and 6 full arches) manufactured via computer-aided-design/computer-assisted-manufacturing and starting from the point of intraoral scans of novel CHAs (i-Physio®, LYRA-ETK, Sallanches, France). Patients were followed for one year.

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Exfoliation syndrome genetics in the era of post-GWAS.

Vision Res

January 2025

Department of Cellular Biology and Anatomy, Augusta University, Augusta, GA, USA; Center for Biotechnology and Genomic Medicine, Augusta University, Augusta, GA, USA; James and Jean Culver Vision Discovery Institute, Medical College of Georgia, Augusta University, Augusta, GA, USA. Electronic address:

Exfoliation syndrome (XFS), or pseudoexfoliation syndrome, is considered a systemic disorder that leads to glaucoma with progressive visual field loss. A better insight into the underlying pathogenic mechanism will help diagnose the disease and prevent and slow progression. Here, we provide an overview of disease pathogenesis in the light of GWAS and multi-omics research.

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The avian influenza is a serious infection caused by influenza virus that is native to birds. Avian influenza remains a global challenge due to high transmission and mortality rates. The highly pathogenic strain of H5N1 resulted in significant outbreaks and deaths globally since the late 1800s.

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Answering the "100 Most Important Family Medicine Research Questions" from the 1985 Hames Consortium.

J Am Board Fam Med

November 2024

From the Department of Family and Community Medicine, Medical College of Georgia at Augusta University, Augusta, GA (CJWL, DAS); Department of Family Medicine and Population Health, Virginia Commonwealth University, Richmond, VA (JB); Medical College of Georgia at Augusta University, Augusta, GA (MLM, MVG, NB, LAM).

Introduction: The 1985 Hames Consortium convened family medicine researchers to identify outstanding questions in their practice.

Method: In this descriptive review, we collected, codified, and analyzed available literature to describe the availability of evidence to answer these questions.

Results: Of 136 total questions, researchers rated 33 questions as not at all answered (24.

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CERA: A Vehicle for Facilitating Research in Family Medicine.

J Am Board Fam Med

November 2024

From the Department of Family and Community Medicine, Medical College of Georgia at Augusta University, Augusta, GA (DAS); Family Medicine Program, New York Presbyterian/Columbia, New York, NY (HLP); Department of Family Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD (WPG).

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Current and Future Challenges to Publishing Family Medicine Research.

J Am Board Fam Med

November 2024

From the Department of Family and Community Medicine of the Medical College of Georgia at Augusta University and Deputy Editor of the Journal of the American Board of Family Medicine (DAS); Department of Family Medicine and Community Health at the University of Wisconsin School of Medicine and Public Health, Madison and Editor-in-Chief of Family Medicine (SBS); Department of Family Medicine at Georgetown University School of Medicine and Editor-in-Chief of American Family Physician (SMS).

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Article Synopsis
  • This text discusses the effectiveness and risks of revising failed shoulder surgeries using total shoulder arthroplasty (TSA), especially in comparison to reverse prostheses which have been more successful in revisions.
  • A systematic review analyzed 13 studies with 312 patients, finding that 39% had complications and 12% needed further revision. Several clinical outcomes improved post-surgery, but they weren't statistically significant.
  • The study concludes that while revision to TSA can be suitable for some patients, the high complication rates and specific challenges like glenoid loosening limit its overall viability as a revision option.
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Novel role of curcumin as inhibitor of β-amyloid-induced lamin fragmentation.

Histochem Cell Biol

November 2024

Department of Biomedical Sciences, Chosun University, Gwangju, 61452, Republic of Korea.

Article Synopsis
  • - Oligomer amyloid beta 42 (Aβ) is a major contributor to Alzheimer's disease, causing harmful effects on cell structures called lamins; curcumin shows potential in protecting against this damage.
  • - The study conducted on human neuroblastoma cells revealed that curcumin significantly decreased Aβ aggregation and its harmful uptake into cells, ultimately preventing cell death.
  • - Curcumin also reduced the rise in intracellular calcium and inhibited related enzyme activity, providing a new perspective on how it may offer protection in Alzheimer's treatment strategies.
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Early expression of neuroinflammation in an untreated fatal case of diabetic ketoacidosis.

Arch Endocrinol Metab

November 2024

University of North Carolina Division of Pediatric Endocrinology Chapel HillNC United States Division of Pediatric Endocrinology, University of North Carolina, Chapel Hill NC.

Article Synopsis
  • A case study analyzes a young adult who experienced lethargy and weight loss before dying, with signs suggesting worsening metabolic health over time.
  • This research is the first to examine human brain tissue from a type 1 diabetes patient experiencing diabetic ketoacidosis (DKA) before treatment, comparing it to a treated patient of similar demographics.
  • Results indicate neuroinflammatory markers were lower in the untreated DKA brain; dehydration may reduce inflammation, while rehydration might increase it, highlighting potential therapeutic avenues to combat neuroinflammation and related cognitive issues.
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Purpose: Doxorubicin, bleomycin, vinblastine, dacarbazine (ABVD) chemotherapy is the current standard treatment for early-stage Hodgkins lymphoma (HL). The use of consolidative radiation therapy (RT) in addition to chemotherapy may lead to better survival rates but is controversial because of concerns about long-term toxicity. The aim of this study is to compare outcomes of patients receiving ABVD chemotherapy alone (CTX alone) versus ABVD with consolidative RT (CMT).

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Podocytes are specialized cells within the glomerular filtration barrier, which are crucial for maintaining glomerular structural integrity and convective ultrafiltration. Podocytes exhibit a unique arborized morphology with foot processes interfacing by slit diaphragms, ladder-like, multimolecular sieves, which provide size and charge selectivity for ultrafiltration and transmembrane signaling. Podocyte dysfunction, resulting from oxidative stress, dysregulated prosurvival signaling, or structural damage, can drive the development of proteinuria and glomerulosclerosis in hypertensive nephropathy.

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Background: Invasive candidiasis/candidemia (IC/C) is associated with a substantial health economic burden driven primarily by prolonged hospital stay. The once-weekly IV echinocandin, rezafungin acetate, has demonstrated non-inferiority to caspofungin in the treatment of IC/C. This paper reports a post hoc pooled exploratory analysis of length of stay (LoS) for hospital and intensive care unit (ICU) stays in two previously published clinical trials (ReSTORE [NCT03667690] and STRIVE [NCT02734862], that compared rezafungin with daily IV caspofungin (stable patients in the caspofungin group who met relevant criteria could step down to fluconazole after 3 days or more).

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Background: Synovial sarcoma (SS) is typically diagnoses in young adults and usually appears in the extremities and soft tissues. However, it can sometimes arise in visceral organs. This study examines the differences in patient demographics, clinical features, and survival rates between soft tissue and visceral synovial sarcoma.

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Enhanced vasoconstriction in sickle cell disease is dependent on ETA receptor activation.

Clin Sci (Lond)

December 2024

Section of Cardiorenal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, U.S.A.

Article Synopsis
  • * In research using mice, SCD was found to enhance vasoconstriction (narrowing of blood vessels) through the alpha-1 adrenergic receptor, particularly by increasing the expression of the alpha-1a receptor in the aortic tissue of SCD mice compared to controls.
  • * Treatment with ambrisentan, an ETA receptor blocker, improved blood vessel function in both mice and SCD patients, suggesting that targeting the ET-1 pathway could help improve vascular health in individuals with
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Mid-late gestation leptin infusion induces placental mitochondrial and endoplasmic reticulum unfolded protein responses in a mouse model of preeclampsia.

Placenta

December 2024

Department of Physiology, Development & Neuroscience, University of Cambridge, UK; Centre for Trophoblast Research, University of Cambridge, UK; BHF Cardiovascular Centre for Research Excellence, University of Cambridge, UK; Strategic Research Initiative in Reproduction, University of Cambridge, UK. Electronic address:

Introduction: Preeclamptic patients, both lean and obese, present with elevated leptin levels which are associated with the development of maternal endothelial dysfunction and adverse fetal outcomes, such as growth restriction, leading to low birth weight. Recent studies in pregnant mice demonstrate that mid-late gestation leptin infusion induces clinical characteristics of preeclampsia, including elevated maternal blood pressure, maternal endothelial dysfunction and fetal growth restriction. However, whether leptin triggers placental stress responses that contribute to adverse fetal outcomes as in preeclampsia is unknown.

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A PRKN-independent mechanism regulating cardiac mitochondrial quality control.

Autophagy

January 2025

Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, USA.

PRKN-dependent mitophagy plays a crucial role in maintaining mitochondrial health. Yet, PRKN-deficient mice do not exhibit mitochondrial and cardiac phenotypes at baseline, suggesting the existence of other mitochondrial ubiquitin (Ub) ligases. Here, we discuss our recent work identifying RNF7/RBX2 as a novel mitochondrial Ub ligase.

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Alzheimer's disease (AD) is a challenging medical issue that requires efficacious treatment options to improve long-term quality of life. Cannabidiol (CBD) is a cannabis-derived phytocannabinoid with potential health benefits, including reports from our laboratory and others showing a therapeutic role in the pre-clinical treatment of AD; however, the mechanisms whereby CBD affects AD progression remain undefined. Innate lymphoid cells (ILCs) are recently discovered immune cells that initiate and orchestrate inflammatory responses.

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: To evaluate the clinical performance of two optical coherence tomography angiography (OCTA) devices, including a semi-automated device, with respect to image quality and pathology detection, with fluorescein angiography (FA) and indocyanine green angiography (ICGA) serving as the reference standards. : In this prospective cross-sectional study, normal eyes and those with various retinal and choroidal pathologies were enrolled and underwent OCTA scanning using semi-automated 3D OCT-1 Maestro2 and Cirrus™ HD-OCT 5000 devices, as well as FA/ICGA imaging. OCTA scans and FA/ICGA images were independently graded for image quality and the visibility of prespecified anatomic vascular features, along with the presence or absence of pathology on the OCTA scans and the FA/ICGA images (within regions corresponding to the OCTA scan areas).

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Visualization of endogenous G proteins on endosomes and other organelles.

Elife

November 2024

Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, United States.

Classical G-protein-coupled receptor (GPCR) signaling takes place in response to extracellular stimuli and involves receptors and heterotrimeric G proteins located at the plasma membrane. It has recently been established that GPCR signaling can also take place from intracellular membrane compartments, including endosomes that contain internalized receptors and ligands. While the mechanisms of GPCR endocytosis are well understood, it is not clear how well internalized receptors are supplied with G proteins.

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The protein corona formed on nanoparticles (NPs) has potential as a valuable diagnostic tool for improving plasma proteome coverage. Here, we show that spiking small molecules, including metabolites, lipids, vitamins, and nutrients into plasma can induce diverse protein corona patterns on otherwise identical NPs, significantly enhancing the depth of plasma proteome profiling. The protein coronas on polystyrene NPs when exposed to plasma treated with an array of small molecules allows for the detection of 1793 proteins marking an 8.

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