16,033 results match your criteria: "Medical College of Georgia[Affiliation]"
Exp Neurol
February 2025
Departments of Neurology, Medical College of Georgia, Augusta University, Augusta, USA.
Transl Vis Sci Technol
November 2024
Department of Cellular Biology and Anatomy, Center for Biotechnology and Genomic Medicine, James and Jean Culver Vision Discovery Institute, Augusta University, Augusta, GA, USA.
Transl Sports Med
November 2024
Department of Orthopaedic Surgery, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
There is growing concern over the safety of artificial turf when it comes to the incidence of player injuries. The artificial surfaces can withstand more play, are cheaper to maintain, and are more predictable. However, there is concern that this beneficial durability comes at the expense of the forgiveness of the surface, leading to more injuries.
View Article and Find Full Text PDFCardiol Clin
February 2025
Department of Medicine, Cardio-Oncology Program, Cardiology Division, Medical College of Georgia at Augusta University, Augusta, GA, USA; Division of Cardiology, Department of Medicine, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA. Electronic address:
This review goes beyond traditional approaches in cardio-oncology, highlighting often-neglected factors impacting patient care. Social determinants, environment, health care access, and gut microbiome significantly influence patient outcomes. Powerful tools like multi-omics and wearable technologies offer deeper insights into real-world experiences.
View Article and Find Full Text PDFJ Dent
January 2025
Department of Dental Sciences, Vita Salute S. Raffaele University, Milan, Italy.
Objectives: To present the clinical results obtained using a novel coded healing abutment (CHA).
Methods: We evaluated 103 patients with fixed implant-supported zirconia restorations (90 single crowns, 26 partial dentures, and 6 full arches) manufactured via computer-aided-design/computer-assisted-manufacturing and starting from the point of intraoral scans of novel CHAs (i-Physio®, LYRA-ETK, Sallanches, France). Patients were followed for one year.
Vision Res
January 2025
Department of Cellular Biology and Anatomy, Augusta University, Augusta, GA, USA; Center for Biotechnology and Genomic Medicine, Augusta University, Augusta, GA, USA; James and Jean Culver Vision Discovery Institute, Medical College of Georgia, Augusta University, Augusta, GA, USA. Electronic address:
Exfoliation syndrome (XFS), or pseudoexfoliation syndrome, is considered a systemic disorder that leads to glaucoma with progressive visual field loss. A better insight into the underlying pathogenic mechanism will help diagnose the disease and prevent and slow progression. Here, we provide an overview of disease pathogenesis in the light of GWAS and multi-omics research.
View Article and Find Full Text PDFPharmacotherapy
November 2024
Clinical and Administrative Pharmacy Sciences, College of Pharmacy, Howard University, Washington, DC, USA.
The avian influenza is a serious infection caused by influenza virus that is native to birds. Avian influenza remains a global challenge due to high transmission and mortality rates. The highly pathogenic strain of H5N1 resulted in significant outbreaks and deaths globally since the late 1800s.
View Article and Find Full Text PDFJ Am Board Fam Med
November 2024
From the Department of Family and Community Medicine, Medical College of Georgia at Augusta University, Augusta, GA (CJWL, DAS); Department of Family Medicine and Population Health, Virginia Commonwealth University, Richmond, VA (JB); Medical College of Georgia at Augusta University, Augusta, GA (MLM, MVG, NB, LAM).
Introduction: The 1985 Hames Consortium convened family medicine researchers to identify outstanding questions in their practice.
Method: In this descriptive review, we collected, codified, and analyzed available literature to describe the availability of evidence to answer these questions.
Results: Of 136 total questions, researchers rated 33 questions as not at all answered (24.
J Am Board Fam Med
November 2024
From the Department of Family and Community Medicine, Medical College of Georgia at Augusta University, Augusta, GA (DAS); Family Medicine Program, New York Presbyterian/Columbia, New York, NY (HLP); Department of Family Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD (WPG).
J Am Board Fam Med
November 2024
From the Department of Family and Community Medicine of the Medical College of Georgia at Augusta University and Deputy Editor of the Journal of the American Board of Family Medicine (DAS); Department of Family Medicine and Community Health at the University of Wisconsin School of Medicine and Public Health, Madison and Editor-in-Chief of Family Medicine (SBS); Department of Family Medicine at Georgetown University School of Medicine and Editor-in-Chief of American Family Physician (SMS).
Shoulder Elbow
September 2024
Department of Orthopaedic Surgery, Emory University, Atlanta, GA, USA.
Histochem Cell Biol
November 2024
Department of Biomedical Sciences, Chosun University, Gwangju, 61452, Republic of Korea.
Arch Endocrinol Metab
November 2024
University of North Carolina Division of Pediatric Endocrinology Chapel HillNC United States Division of Pediatric Endocrinology, University of North Carolina, Chapel Hill NC.
Adv Radiat Oncol
December 2024
Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia.
Purpose: Doxorubicin, bleomycin, vinblastine, dacarbazine (ABVD) chemotherapy is the current standard treatment for early-stage Hodgkins lymphoma (HL). The use of consolidative radiation therapy (RT) in addition to chemotherapy may lead to better survival rates but is controversial because of concerns about long-term toxicity. The aim of this study is to compare outcomes of patients receiving ABVD chemotherapy alone (CTX alone) versus ABVD with consolidative RT (CMT).
View Article and Find Full Text PDFHypertension
January 2025
Division of Nephrology, Department of Medicine (O.P.), Medical University of South Carolina, Charleston, SC.
Podocytes are specialized cells within the glomerular filtration barrier, which are crucial for maintaining glomerular structural integrity and convective ultrafiltration. Podocytes exhibit a unique arborized morphology with foot processes interfacing by slit diaphragms, ladder-like, multimolecular sieves, which provide size and charge selectivity for ultrafiltration and transmembrane signaling. Podocyte dysfunction, resulting from oxidative stress, dysregulated prosurvival signaling, or structural damage, can drive the development of proteinuria and glomerulosclerosis in hypertensive nephropathy.
View Article and Find Full Text PDFCrit Care
November 2024
Division of Infectious Diseases, Department of Internal Medicine, and Department of Medical Microbiology and Immunology, University of California Davis Medical Center, Sacramento, CA, USA.
Background: Invasive candidiasis/candidemia (IC/C) is associated with a substantial health economic burden driven primarily by prolonged hospital stay. The once-weekly IV echinocandin, rezafungin acetate, has demonstrated non-inferiority to caspofungin in the treatment of IC/C. This paper reports a post hoc pooled exploratory analysis of length of stay (LoS) for hospital and intensive care unit (ICU) stays in two previously published clinical trials (ReSTORE [NCT03667690] and STRIVE [NCT02734862], that compared rezafungin with daily IV caspofungin (stable patients in the caspofungin group who met relevant criteria could step down to fluconazole after 3 days or more).
View Article and Find Full Text PDFSurgeon
November 2024
Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Background: Synovial sarcoma (SS) is typically diagnoses in young adults and usually appears in the extremities and soft tissues. However, it can sometimes arise in visceral organs. This study examines the differences in patient demographics, clinical features, and survival rates between soft tissue and visceral synovial sarcoma.
View Article and Find Full Text PDFClin Sci (Lond)
December 2024
Section of Cardiorenal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, U.S.A.
Placenta
December 2024
Department of Physiology, Development & Neuroscience, University of Cambridge, UK; Centre for Trophoblast Research, University of Cambridge, UK; BHF Cardiovascular Centre for Research Excellence, University of Cambridge, UK; Strategic Research Initiative in Reproduction, University of Cambridge, UK. Electronic address:
Introduction: Preeclamptic patients, both lean and obese, present with elevated leptin levels which are associated with the development of maternal endothelial dysfunction and adverse fetal outcomes, such as growth restriction, leading to low birth weight. Recent studies in pregnant mice demonstrate that mid-late gestation leptin infusion induces clinical characteristics of preeclampsia, including elevated maternal blood pressure, maternal endothelial dysfunction and fetal growth restriction. However, whether leptin triggers placental stress responses that contribute to adverse fetal outcomes as in preeclampsia is unknown.
View Article and Find Full Text PDFAutophagy
January 2025
Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, USA.
PRKN-dependent mitophagy plays a crucial role in maintaining mitochondrial health. Yet, PRKN-deficient mice do not exhibit mitochondrial and cardiac phenotypes at baseline, suggesting the existence of other mitochondrial ubiquitin (Ub) ligases. Here, we discuss our recent work identifying RNF7/RBX2 as a novel mitochondrial Ub ligase.
View Article and Find Full Text PDFInt J Mol Sci
November 2024
Department of Neurology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Alzheimer's disease (AD) is a challenging medical issue that requires efficacious treatment options to improve long-term quality of life. Cannabidiol (CBD) is a cannabis-derived phytocannabinoid with potential health benefits, including reports from our laboratory and others showing a therapeutic role in the pre-clinical treatment of AD; however, the mechanisms whereby CBD affects AD progression remain undefined. Innate lymphoid cells (ILCs) are recently discovered immune cells that initiate and orchestrate inflammatory responses.
View Article and Find Full Text PDFJ Clin Med
October 2024
Tufts Medical Center, Boston, MA 02111, USA.
: To evaluate the clinical performance of two optical coherence tomography angiography (OCTA) devices, including a semi-automated device, with respect to image quality and pathology detection, with fluorescein angiography (FA) and indocyanine green angiography (ICGA) serving as the reference standards. : In this prospective cross-sectional study, normal eyes and those with various retinal and choroidal pathologies were enrolled and underwent OCTA scanning using semi-automated 3D OCT-1 Maestro2 and Cirrus™ HD-OCT 5000 devices, as well as FA/ICGA imaging. OCTA scans and FA/ICGA images were independently graded for image quality and the visibility of prespecified anatomic vascular features, along with the presence or absence of pathology on the OCTA scans and the FA/ICGA images (within regions corresponding to the OCTA scan areas).
View Article and Find Full Text PDFAm J Obstet Gynecol
November 2024
Mercer University School of Medicine, Macon, GA.
Elife
November 2024
Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, United States.
Classical G-protein-coupled receptor (GPCR) signaling takes place in response to extracellular stimuli and involves receptors and heterotrimeric G proteins located at the plasma membrane. It has recently been established that GPCR signaling can also take place from intracellular membrane compartments, including endosomes that contain internalized receptors and ligands. While the mechanisms of GPCR endocytosis are well understood, it is not clear how well internalized receptors are supplied with G proteins.
View Article and Find Full Text PDFNat Commun
November 2024
Precision Health Program, Michigan State University, East Lansing, MI, USA.
The protein corona formed on nanoparticles (NPs) has potential as a valuable diagnostic tool for improving plasma proteome coverage. Here, we show that spiking small molecules, including metabolites, lipids, vitamins, and nutrients into plasma can induce diverse protein corona patterns on otherwise identical NPs, significantly enhancing the depth of plasma proteome profiling. The protein coronas on polystyrene NPs when exposed to plasma treated with an array of small molecules allows for the detection of 1793 proteins marking an 8.
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