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The protective effect of caffeic acid on global cerebral ischemia-reperfusion injury in rats.
Behav Brain Funct
April 2015
Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Medical College Rd. No 1, Chongqing, 400016, P. R. China.
Article Synopsis
- Ischemic stroke is a major global health issue caused by reduced blood flow to the brain, leading to serious damage and disability.
- Recent research indicates that 5-Lipoxygenase (5-LO) inhibitors, like caffeic acid derived from plants, may protect against ischemic damage in animal studies.
- In an experiment with rats, caffeic acid improved memory performance, reduced neuron injury in the hippocampus, and positively influenced oxidative stress markers compared to untreated ischemia/reperfusion groups.