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Coxsackievirus B3-induced myocarditis: differences in the immune response of C57BL/6 and Balb/c mice.
Med Microbiol Immunol
May 2004
Institute of Virology and Antiviral Therapy, Medical Centre at the Friedrich Schiller University Jena, Hans-Knöll-Strasse 8, 07745 Jena, Germany.
Coxsackievirus B3 (CVB3) infections are the most frequent causes of human myocarditis, often resulting in chronic stages characterized by fibrosis and loss of function. This disease is called dilated cardiomyopathy (DCM). Persistent virus in the myocardium may lead to chronic activation of fibroblasts, and subsequently, to fibrosis of the myocardium.
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