Isolation of non-tuberculous mycobacteria at three rural settings in Zambia; a pilot study.

To assess the role of non-tuberculous mycobacteria (NTM) as a cause of tuberculosis-like diseases in Zambia, 167 chronically ill patients, hospitalized in three rural hospitals in Katete, Sesheke and Chilonga, were examined by microscopy and liquid culture for the presence of NTM. The percentages of patients with a positive culture for Mycobacterium tuberculosis complex were similar in the three geographical locations (19-25%). In contrast, the percentage of NTM ranged from 78% in Katete and 65% in Sesheke to 21% in Chilonga.

Symptomatic hypoparathyroidism based on a 22q11 deletion first diagnosed in a 43-year-old woman.

Congenital hypoparathyroidism usually manifests in early childhood with hypocalcaemia with or without clinical characteristics. This report describes a Caucasian woman who, at the age of 43 years, was diagnosed with dysgenesis of the parathyroid glands due to a de novo microdeletion in chromosome 22q11 or DiGeorge syndrome. This syndrome is characterised by a considerable variability in clinical symptoms, including heart defects, thymic hypoplasia and mental retardation.

Nontuberculous mycobacteria, zambia.

Clinical relevance of nontuberculous mycobacteria (NTM) isolated from 180 chronically ill patients and 385 healthy controls in Zambia was evaluated to examine the contribution of these isolates to tuberculosis (TB)-like disease. The proportion of NTM-positive sputum samples was significantly higher in the patient group than in controls; 11% and 6%, respectively (p<0.05).

Traumatic intercostal pulmonary herniation: a case report.

We report a case of intercostal pulmonary hernia through a defect in the wall of the thoracic cavity which occurred after blunt thoracic trauma. Diagnosis of pulmonary herniation was confirmed radiologically by chest X-ray and computed tomographic scan. After initial inspection by video-assisted thoracoscopy which also revealed a diaphragmatic rupture, a postero-lateral thoracotomy was performed.

Concurrent tubal ectopic pregnancy and acute appendicitis.

A 25-year-old woman had signs of an acute surgical abdomen. Differential diagnoses were ectopic pregnancy and acute appendicitis. Diagnostic laparoscopy revealed an apparent inflamed appendix and left-sided unruptured tubal ectopic pregnancy.

Herniation of the gall bladder through the abdominal wall.

We present a case of an 81-year-old woman, without medical history, with a swelling in the right lateral abdominal wall. Ultrasound and multislice CT were sufficient to confirm the diagnosis of a herniated gall bladder through the abdominal wall. This is the first case in which MRI proved to be a useful modality to exclude malignant characteristics and revealed an accurate differentiation between the gall bladder and the different layers of the abdominal wall.

The starting dose of levothyroxine in primary hypothyroidism treatment: a prospective, randomized, double-blind trial.

Background: The treatment of hypothyroidism with levothyroxine is effective and simple; however, recommendations for the starting dose vary considerably. To our knowledge, the levothyroxine starting dose has never been studied prospectively.

Methods: We conducted a prospective, randomized, double-blind trial that compared a full starting levothyroxine dose of 1.

Ultrasound-guided percutaneous transabdominal treatment of a type 2 endoleak.

We describe a case of multiple endoleaks following endovascular repair of an abdominal aortic aneurysm, treated by various methods. A new transabdominal embolization approach using color-flow duplex guidance is presented.

Mycotic aneurysm of the celiac trunk: from early CT sign to rupture.

We present a case of the rapid development and rupture of a mycotic celiac trunk aneurysm. Initially on multislice computed tomography (ms-CT) there was a normal celiac trunk with minimal haziness of the surrounding fat. Only 2 weeks later the patient went into hypovolemic shock due to a ruptured celiac aneurysm.

Procalcitonin as an early marker of infection in neonates and children.

A child or neonate presenting with fever is a common medical problem. To differentiate between those with a severe bacterial infection and those with a localised bacterial or a viral infection can be a challenge. This review provides an overview of neonatal and paediatric studies that assess the use of procalcitonin as an early marker of bacterial infection.

Surgical validation of unenhanced helical computed tomography in acute appendicitis.

Background: Surgery for pain in the right lower quadrant of the abdomen remains a clinical dilemma. This prospective study assessed the accuracy of preoperative unenhanced helical computed tomography (CT) in the evaluation of patients with suspected acute appendicitis.

Methods: One hundred and three adult patients with suspected acute appendicitis underwent unenhanced helical CT of the abdomen.

Sentinel lymph node biopsy in breast cancer: results of intradermal periareolar tracer injection and follow-up of sentinel lymph node-negative patients.

Several methods are in use for identification of the sentinel lymph node (SLN) in breast cancer. We set up the hypothesis that intradermal (i.d.

The significance of angiogenesis in malignant pheochromocytomas.

The purpose of this study was to investigate tumor angiogenesis in a series of benign and malignant pheochromocytomas and to determine whether there is a correlation between angiogenesis and the presence of distant metastases. In this study, the CD31 monoclonal antibody was selected to measure intratumoral microvessel density. Nineteen patients with malignant pheochromocytomas and nineteen patients with benign pheochromocytomas who underwent operation were studied.

Cardiac and metabolic effects in patients who present with a multinodular goitre.

Twenty-six consecutive patients who presented with clinically euthyroid multinodular goitre were studied for an overnight fasting serum lipid profile and 24 h Holter monitoring. Mean serum TSH was 0.6 +/- 0.

A high prevalence of culture-positive extrapulmonary tuberculosis in a large Dutch teaching hospital.

Background: In the Netherlands the incidence of tuberculosis (TB) has increased during the last decade. Growing immigration and international travel were important determining factors. To determine if this has resulted in altered clinical manifestations of the disease, we assessed the clinical spectrum of all TB cases diagnosed at our hospital in the period 1994 to 2000.