The Protective Effect of Chrysin Against Cisplatin İnduced Ototoxicity in Rats.

Ototoxicity is a common side effect of cisplatin chemotherapy. The aim of this study was to investigate the potential protective effect of chrysin against cisplatin-induced ototoxicity. Thirty-four adult female Wistar albino rats were separated into four groups: a cisplatin group (Group A), with cisplatin administered to ten rats once daily for three consecutive days at doses of 8 mg/kg body weight intraperitoneally (i.

Dry Eye Related to Commonly Used New Antidepressants.

Antidepressants may have an impact on the course of eye dryness. The aim of this study was to investigate the effects of commonly used new antidepressants on eye wetting. Fifty-four patients using new antidepressants and 57 controls were recruited.

Otitis complicated by Jacod's syndrome with unusal facial nerve involvement: Case report and review of literature.

Otitis media is a well-known condition and its infra-temporal and intracranial complications are extremely rare because of the widespread usage of antibiotic treatment. We report a case of 63-year-old female with complaints of right-sided facial pain and diplopia. She had a history of acute otitis media before 4 months of admission to our neurology unit.

Evaluation of heart rate recovery in patients with primary nephrotic syndrome.

Background/aim: Abnormal heart rate recovery after an exercise stress test is a strong predictor of cardiovascular death in healthy subjects and various patient groups. The aim of the present study was to investigate heart rate recovery (HRR), a cardiovascular risk factor, in patients with primary nephrotic syndrome (NS).

Material And Methods: Forty patients with primary NS (mean age 39.

The effects of human amniotic fluid and different bone grafts on vertebral fusion in an experimental rat model.

Objective: The high risk of nonunion represents a challenge in vertebral surgery, thus stimulating new strategies to improve fusion rates. We investigated the effect of 2 different bone grafts and amniotic fluid application on radiologically and histologically evaluated vertebral fusion in an experimental rat model.

Materials And Methods: Forty-eight 24-week-old Sprague Dawley rats were included and assigned into 1 of 4 groups: allograft group, allograft plus human amniotic fluid group, demineralized bone matrix (DBM) group, or DBM plus human amniotic fluid group.

Gallstone disease does not predict liver histology in nonalcoholic fatty liver disease.

Background/aims: We sought to examine whether the presence of gallstone disease (GD) in patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD) is associated with liver fibrosis and histological nonalcoholic steatohepatitis (NASH) score.

Methods: We included 441 Turkish patients with biopsy-proven NAFLD. GD was diagnosed in the presence of sonographic evidence of gallstones, echogenic material within the gallbladder with constant shadowing and little or no visualization of the gallbladder or absence of gallbladder at ultrasonography, coupled with a history of cholecystectomy.

Deregulated WNT signaling in childhood T-cell acute lymphoblastic leukemia.

WNT signaling has been implicated in the regulation of hematopoietic stem cells and plays an important role during T-cell development in thymus. Here we investigated WNT pathway activation in childhood T-cell acute lymphoblastic leukemia (T-ALL) patients. To evaluate the potential role of WNT signaling in T-cell leukomogenesis, we performed expression analysis of key components of WNT pathway.

Effect of orally administered simvastatin on prevention of postoperative adhesion in rats.

Aim: Formation of adhesions in the abdominal region appearing after abdominal pelvic surgery lead to infertility, chronic pelvic pain, intestinal obstructions, difficulty and morbidity at the following operations, and increased morbidity. The aim of our study is to examine the effectiveness of orally administered simvastatin on preventing the postoperative adhesion.

Materials And Methods: 20 male Wistar Albino rats weighing 230-250 gr were used.

Effectiveness of MESNA on the success of cholesteatoma surgery.

Importance: It is important that chronic otitis media with cholesteatoma be treated successfully in patients to protect them from having repeated surgeries with related surgical co-morbidities and hearing loss.

Objective: To evaluate the effectiveness of MESNA usage on the residual cholesteatoma rates of the patients who underwent surgery due to chronic otitis media with cholesteatoma.

Design: Retrospective single-institution study of a prospectively collected database.

Comparison between cartilage and fascia grafts in type 1 tympanoplasty.

Objectives: We retrospectively analysed long-term hearing results and graft take rates in our cases with both temporalis muscle fascia and the cartilage island technique.

Methodology: Between September 2000 and October 2011, a total of 489 patients underwent cartilage tympanoplasty, while 318 patients had tympanoplasty using fascia. In this study we included patients with a follow-up period of at least 3 years.

Impaired left ventricular mechanics in nonalcoholic fatty liver disease: a speckle-tracking echocardiography study.

Background: Nonalcoholic fatty liver disease (NAFLD) encompasses a disease spectrum ranging from simple steatosis to nonalcoholic steatohepatitis (NASH). We aimed to evaluate left ventricular (LV) systolic function using two-dimensional speckle-tracking echocardiography (2D-STE) in patients with NAFLD and to investigate whether any changes exist among the subgroups of NAFLD.

Materials And Methods: We included 55 NAFLD patients and 21 healthy controls.

Effect of accommodation on corneal topography.

Purpose: To investigate the effect of accommodation on corneal topography in healthy subjects.

Methods: Using a Nidek OPD-Scan ARK-10000, corneal topographic images, images of the iris, and the refraction of 18 eyes of 10 normal subjects with a mean age of 26.3 ± 7.

Elevated troponin level with negative outcome was found in ischemic stroke.

Background. Troponin increment is a highly sensitive and specific marker of myocardial necrosis. The reason of high troponin levels in acute stroke is not clear.

Low scores on the Benton Facial Recognition Test associated with vertebrobasilar insufficiency.

Background: Decreased posterior cerebral circulation has been observed in patients with vertebrobasilar insufficiency (VBI). Reduced cerebral perfusion may have an impact on mental performance as measured by the Benton Facial Recognition Test (BFRT). We evaluated the usefulness of BFRT in identifying cognitive decline in patients with VBI by correlating test performance with total blood flow in the vertebrobasilar system and other variables such as educational level and gender.

The use of bone cement for ossicular chain defects.

Bone cement is a good and cheap option for some ossicular chain problems such as incudostapedial re-bridging. The purpose of this retrospective study is to evaluate the audiologic results after reconstruction of three different types of ossicular chain defects, using bone cement. Group 1 consists of 42 patients who underwent an ossiculoplasty using bone cement between the damaged long process of the incus and an intact stapes superstructure.