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Valproate, risperidone, and paliperidone: A case of valproate-induced hyperammonemic encephalopathy.
Ment Health Clin
February 2024
Medical Director, McNew Medical Center, Chief of Psychiatry, Behavioral Health, Luminis Health, Annapolis, Maryland.
Article Synopsis
- Hyperammonemia can occur as a side effect of valproate, leading to a serious condition called valproate-induced hyperammonemic encephalopathy (VHE), especially when used with other antiepileptic drugs.
- A case involving a 20-year-old male with bipolar disorder highlights the risks of VHE when valproate is combined with risperidone and paliperidone palmitate.
- After starting treatment with these medications, the patient experienced severe symptoms including drowsiness and vomiting, which led to a diagnosis of hyperammonemia and a transfer to the emergency department for urgent care.