1 results match your criteria: "McMaster University. Department of Biochemistry and Biomedical Sciences. HSC4H24A[Affiliation]"
Hypothesis: Huntingtin may function in membrane association and vesicular trafficking.
Biochem Cell Biol
December 2006
McMaster University. Department of Biochemistry and Biomedical Sciences. HSC4H24A, 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada.
Huntington's disease is a progressive neurodegenerative genetic disorder that is caused by a CAG triplet-repeat expansion in the first exon of the IT15 gene. This CAG expansion results in polyglutamine expansion in the 350 kDa huntingtin protein. The exact function of huntingtin is unknown.
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