1 results match your criteria: "McMaster University and Hamilton Health Science Centre[Affiliation]"
Predictable prolonged suppression of gastric acidity with a novel proton pump inhibitor, AGN 201904-Z.
Aliment Pharmacol Ther
July 2008
Division of Gastroenterology, McMaster University and Hamilton Health Science Centre, Hamilton, ON, Canada.
Background: AGN 201904-Z is a new, slowly absorbed, acid-stable pro-proton pump inhibitor (pro-PPI) rapidly converted to omeprazole in the systemic circulation giving a prolonged residence time.
Aim: To investigate pharmacodynamics and pharmacokinetics of AGN 201904-Z compared to esomeprazole.
Methods: A randomized, open-label, parallel group, investigator-blinded intragastric pH study was conducted in 24 healthy Helicobacter pylori negative male volunteers.