1 results match your criteria: "McLean Hospital and Harvard Medical School Boston[Affiliation]"
Juvenile methylphenidate reduces prefrontal cortex plasticity via D3 receptor and BDNF in adulthood.
Front Synaptic Neurosci
January 2014
Department of Psychiatry, McLean Hospital and Harvard Medical School Boston, MA, USA.
Background: Early drug intervention in childhood disorders aims to maximize individual potential in the short- and long-term. Consistently, juvenile exposure to psychostimulants, such as methylphenidate (MPH), reduces risk for substance use in animals and sub-populations of individuals with attention deficit hyperactivity disorder (ADHD). We investigated the effects of MPH on brain plasticity via dopamine receptor D3 (D3R) and brain-derived neurotrophic factor (BDNF) expression in developing rats.
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