ATN blood biomarkers are related to digital cognitive assessment in type 1 diabetes.

Introduction: Associations between amyloid-tau-neurodegeneration (ATN) plasma biomarkers and cognition have not been characterized in adults with type 1 diabetes (T1D).

Methods: Using data from participants in the Glycemic Variability and Fluctuations in Cognitive Status in Adults with T1D (GluCog) study ( = 114), we evaluated associations between phosphorylated tau (pTau)181, pTau217, β-amyloid 42/40 ratio, glial fibrillary acidic protein (GFAP), and neurofilament light (NfL) and self-administered digital cognitive tests, adjusting for age, sex, education, comorbidities (e.g.

Maternal age effects on offspring lifespan and reproduction vary within a species.

Across diverse taxa, offspring from older mothers have decreased lifespan and fitness. Little is known about the extent to which maternal age effects vary among genotypes for a given species, however, except for studies of a few arthropod species. To investigate the presence and degree of intraspecific variability in maternal age effects, we compared lifespan, reproductive schedule, and lifetime reproductive output of offspring produced by young, middle-aged, and old mothers in four strains of rotifers in the species complex.

Longitudinal associations of apathy and regional tau in mild cognitive impairment and dementia: Findings from the Alzheimer's Disease Neuroimaging Initiative.

Introduction: It is important to study apathy in Alzheimer's disease (AD) to better understand its underlying neurobiology and develop effective interventions. In the current study, we sought to examine the relationships between longitudinal apathy and regional tau burden in cognitively impaired older adults from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database.

Methods: Three hundred and nineteen ADNI participants with mild cognitive impairment (MCI) or AD dementia underwent flortaucipir (FTP) tau positron emission tomography (PET) imaging and clinical assessment with the Neuropsychiatric Inventory (NPI) annually.

Sex differences in risk of Alzheimer's disease in adults with Down syndrome.

Introduction: Adults with Down syndrome (DS) older than 40 have Alzheimer's disease (AD) neuropathology and high risk for dementia, but little is known about the relationship of sex to AD risk in this population.

Methods: Using nonparametric methods and Cox proportional hazards models we analyzed differences in incidence of dementia, by sex, presence of an apolipoprotein E () ε4 or ε2 allele, and dementia duration and decline in 246 adults over 40 with DS.

Results: There was no significant sex difference in risk of AD or rate of cognitive decline.

Sensing a problem: Proof of concept for characterizing and predicting agitation.

Introduction: Agitation, experienced by patients with dementia, is difficult to manage and stressful for caregivers. Currently, agitation is primarily assessed by caregivers or clinicians based on self-report or very brief periods of observation. This limits availability of comprehensive or sensitive enough reporting to detect early signs of agitation or identify its precipitants.