4 results match your criteria: "McGill University Health Centre-Montreal Children's Hospital Research Institute[Affiliation]"
Investigating the use of hair to assess polybrominated diphenyl ether exposure retrospectively.
Ther Drug Monit
April 2014
*Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto; †Department of Pharmacology and Toxicology, University of Toronto; ‡School of Pharmacy, University of Waterloo; §McGill University Health Centre-Montreal Children's Hospital Research Institute; and ¶Ivey Chair in Molecular Toxicology, University of Western Ontario, London, Canada.
Background: Polybrominated diphenyl ethers (PBDEs) are chemicals that are added to a variety of consumer products as flame-retardants and have been classified as emerging endocrine disruptors. They are persistent and have been detected in humans. Previous studies have suggested that hair is a suitable matrix for examining human exposure to organic pollutants such as PBDEs.
View Article and Find Full Text PDFTranscriptional regulation of the human growth hormone receptor (hGHR) gene V2 promoter by transcriptional activators and repressor.
Mol Endocrinol
March 2009
McGill University Health Centre-Montreal Children's Hospital Research Institute, 4060 St. Catherine West, Room 415-1, Montreal, Quebec, Canada H3Z 2Z3.
The V2 transcript is the major ubiquitously expressed human GH receptor (hGHR) mRNA in all tissues examined to date. In a previous investigation, we defined the V2 promoter as TATA-less and exhibiting many characteristics of a housekeeping gene promoter. We also demonstrated that its basal activity is determined by several different cis-regulatory regions within both the promoter and the V2 exon.
View Article and Find Full Text PDFExpression of the hepatic specific V1 messenger ribonucleic acid of the human growth hormone receptor gene is regulated by hepatic nuclear factor (HNF)-4alpha2 and HNF-4alpha8.
Mol Endocrinol
February 2008
McGill University Health Centre-Montreal Children's Hospital Research Institute, 4060 St Catherine West, Montreal, Quebec, Canada.
Human (h) GH plays an essential role in growth and metabolism, and its effectiveness is modulated by the availability of its specific receptor [hGH receptor (hGHR)] on target cells. The hGHR gene has a complex 5'-regulatory region containing multiple first exons. Seven are clustered within two small regions: V2,V3,V9 (module A) and V1,V4,V7,V8 (module B).
View Article and Find Full Text PDFRelationship of the human growth hormone receptor exon 3 genotype with final adult height and bone mineral density.
J Clin Endocrinol Metab
February 2007
Endocrine Research Laboratory, Room 415/1, McGill University Health Centre-Montreal Children's Hospital Research Institute, 4060 Ste Catherine Street West, Montreal, Quebec, Canada H3Z 2Z3.
Context: Three recent clinical studies have reported that two of the most common isoforms of the human GH (hGH) receptor (hGHR), exon 3 full-length (3+) and exon 3 deleted (3-), may have differential effects on the growth response of children receiving hGH therapy, whereas others refute this. However, none of the investigations has explored the relationship between these hGHR isoforms and final adult height (FAH) or measures of bone mineral density (BMD) within a healthy adult population.
Objective: The aim of this study was to investigate the possible influences of hGHR exon 3 isoforms on FAH and BMD measures of a normal population.