36 results match your criteria: "McGill University Health Centre-Montreal Children's Hospital[Affiliation]"
Am J Pathol
December 2024
Program in Biomedical Science, Faculty of Medicine, Université de Montreal, Montreal, Quebec, Canada; Department of Pediatrics, Ophthalmology and Pharmacology, Centre de Recherche du CHU Sainte-Justine, Montréal, Quebec, Canada; School of Optometry, Université de Montréal, Montreal, Quebec, Canada. Electronic address:
The subretina, composed of the choroid and the retinal pigment epithelium (RPE), plays a critical role in proper vision. In addition to phagocytosis of photoreceptor debris, the RPE shuttles oxygen and nutrients to the neuroretina. For their own energy production, RPE cells mainly rely on lactate, a major by-product of glycolysis.
View Article and Find Full Text PDFCurr Opin Pediatr
October 2024
Neonatology - McGill University Health Centre - Montreal Children's Hospital; Department of Pediatrics - McGill University, Montreal, Quebec, Canada.
Purpose Of Review: Pulmonary hypertension (PH) is commonly observed in premature infants with bronchopulmonary dysplasia (BPD) and is associated with poor outcomes and increased mortality. This review explores the management of this intricate condition of the pulmonary vasculature, which exhibits heterogeneous effects and may involve both arterial and postcapillary components.
Recent Findings: Current management of BPD-PH should focus on optimizing ventilatory support, which involves treatment of underlying lung disease, transitioning to a chronic phase ventilation strategy and evaluation of the airway.
Am J Perinatol
November 2024
Department of Pediatrics, Division of Neonatology, McGill University Health Centre-Montreal Children's Hospital, Montreal, Quebec, Canada.
J Pediatr Surg
May 2024
Harvey E. Beardmore Division of Pediatric Surgery, Department of Pediatric Surgery, McGill University Health Center, Montreal Children's Hospital, Canada. Electronic address:
Background: Umbilical hernia (UH) is a common pediatric condition, for which delaying surgical repair for asymptomatic UH until after age 3 is recommended due to a high incidence of spontaneous closure. We aimed to determine the adherence to guidelines, rate of urgent surgical repair, outcomes, cost, and interinstitutional referral patterns of UH repair in the province of Quebec (Canada).
Methods: This was a population-based retrospective cohort study of children 28 days to 17 years old who underwent UH repair between 2010 and 2020 using health administrative databases.
Front Physiol
August 2022
Department of Ophthalmology and Visual Sciences, Research Institute of the McGill University Health Centre/Montreal Children's Hospital, Montreal, QC, Canada.
The electroretinogram (ERG) represents the biopotential evoked by the retina in response to a light stimulus. The flash evoked ERG (fERG) is the ERG modality most frequently used clinically to diagnose and monitor retinal disorders. We hereby present a new method to record spontaneous retinal activity, without the use of a flash stimulus, that we named the resting-state ERG (rsERG).
View Article and Find Full Text PDFJ Perinatol
May 2022
Neonatology-McGill University Health Centre-Montreal Children's Hospital, Department of Pediatrics, McGill University, Montreal, QC, Canada.
J Allergy Clin Immunol Pract
May 2021
Aimmune Therapeutics, Brisbane, Calif; Department of Medicine, University of California San Francisco, San Francisco, Calif. Electronic address:
Transl Vis Sci Technol
July 2020
Department of Ophthalmology & Visual Sciences, Research Institute of the McGill University Health Centre-Montreal Children's Hospital, Montreal, QC, Canada.
Purpose: It has been suggested that retinal blood vessel arborization (RBVA) is unique to each individual. We examined this claim in a pedigree that included two pairs of monozygotic twins.
Methods: Fundus photographs were taken of subjects belonging to this pedigree to compare the pattern of their RBVA.
Doc Ophthalmol
June 2019
Department of Ophthalmology and Neurology-Neurosurgery, Research Institute of the McGill University Health Centre/Montreal Children's Hospital, 1001 Boul. Décarie, Glen Site, Block E, Program Mail Drop Point #EM03211 - Office #EM03238, Montréal, QC, H4A 3J1, Canada.
Purpose: In order to study the OPs, the ERG signal must be filtered to eliminate the low-frequency waves known as the a- and b-waves. Unfortunately, the ISCEV ERG standard does not give clear guidelines on how to proceed apart from indicating that frequencies below 75 Hz should be filtered out when recording scotopic OPs, while no suggestions are offered for the photopic OPs. The purpose of this study was thus to characterize more extensively the effects of various digital filters on the photopic OP waveforms in order to suggest the most appropriate filtering method to record them.
View Article and Find Full Text PDFNat Commun
February 2019
Department of Biochemistry, McGill University, Montreal, QC, H3G 1Y6, Canada.
Inactivating mutations in SMARCA4 (BRG1), a key SWI/SNF chromatin remodelling gene, underlie small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). To reveal its druggable vulnerabilities, we perform kinase-focused RNAi screens and uncover that SMARCA4-deficient SCCOHT cells are highly sensitive to the inhibition of cyclin-dependent kinase 4/6 (CDK4/6). SMARCA4 loss causes profound downregulation of cyclin D1, which limits CDK4/6 kinase activity in SCCOHT cells and leads to in vitro and in vivo susceptibility to CDK4/6 inhibitors.
View Article and Find Full Text PDFMethods Mol Biol
July 2018
Department of Ophthalmology & Neurology-Neurosurgery, Research Institute of the McGill University Health Centre/Montreal Children's Hospital, 1001 Boul. Décarie, Glen Site, Block E, Montreal, QC, Canada, H4A 3J1.
The electroretinogram (ERG) represents the biopotential that is produced by the retina in response to a light stimulus. To date, it remains the best diagnostic tool to objectively evaluate the functional integrity of the normal or diseased retina. In the following pages we briefly review the necessary requirements in order to record and analyze the conventional clinical ERG.
View Article and Find Full Text PDFDoc Ophthalmol
October 2017
Departments of Ophthalmology and Neurology and Neurosurgery, Research Institute of the McGill University Health Centre/Montreal Children's Hospital, Montreal, QC, Canada.
Purpose: Although the DTL fiber electrode has been in use in the ERG field for more than four decades, its composition was never clearly defined. We compared five different types of conductive (DTL type) yarn (differing in terms of mass, number of filaments, and crimping degree) in order to determine whether we could identify one that would be better suited for the recording of ERGs.
Methods: Photopic flash ERGs were recorded from five subjects using the following DTL electrodes: 27/7, 22/1, 11/1, 11/1*2, and 22/1*2.
Biomed Res Int
January 2017
Department of Ophthalmology, Research Institute of the McGill University Health Centre/Montreal Children's Hospital, Montréal, QC, Canada; Department of Neurology-Neurosurgery, Research Institute of the McGill University Health Centre/Montreal Children's Hospital, Montréal, QC, Canada.
The electroretinogram (ERG) is composed of slow (i.e., a-, b-waves) and fast (i.
View Article and Find Full Text PDFTransl Vis Sci Technol
January 2017
Department of Ophthalmology & Neurology-Neurosurgery, Research Institute of the McGill University Health Centre/Montreal Children's Hospital, Montreal, Quebec, Canada.
Purpose: Discrete wavelet transform (DWT) analyses suggest that the 20- and 40-Hz components of the short-flash photopic electroretinogram (ERG) are closely related to the ON and OFF pathways, respectively. With the DWT, we examined how the ERG ON and OFF components are modulated by the stimulus intensity and/or duration.
Methods: Discrete wavelet transform descriptors (20, 40 Hz and 40:20-Hz ratio) were extracted from ERGs evoked to 25 combinations of flash durations (150-5 ms) and strengths (0.
CMAJ Open
July 2016
Department of Epidemiology, Biostatistics and Occupational Health (Lasry, Fuhrer), McGill University, Montréal, Que.; Department of Neurosurgery (Lasry, Marcoux), McGill University Health Centre - Montréal General Hospital, Montréal, Qué.; Department of Surgery (Dudley), Division of Neurosurgery, McGill University Health Centre - Montréal Children's Hospital, Montréal, Qué.; Department of Public Health (Torrie), Cree Board of Health and Social Services of James Bay, Mistissini, Qué.; Department of Public Health (Carlin), Cree Board of Health and Social Services of James Bay, Montréal, Qué.
Background: Indigenous populations are disproportionately affected by traumatic brain injury. These populations rely on large jurisdiction surveillance efforts to inform their prevention strategies, which may not address their needs. We examined the incidence and determinants of traumatic brain injury in an indigenous population in the Terres-Cries-de-la-Baie-James health region of the province of Quebec and compared them with the incidence and determinants in 2 neighbouring health regions and in the province overall.
View Article and Find Full Text PDFMol Endocrinol
September 2014
Departments of Experimental Medicine (S.E., C.G.G.) and Pediatrics (C.G.G.), McGill University, and Endocrine Research Laboratory (S.E., C.G.G.), Research Institute of McGill University Health Centre-Montreal Children's Hospital, Montreal, Quebec, Canada H3Z 2Z3.
Human GH binds to its receptor (GHR) on target cells and activates multiple intracellular pathways, leading to changes in gene expression, differentiation, and metabolism. GHR deficiency is associated with growth and metabolic disorders whereas increased GHR expression has been reported in certain cancers, suggesting that the GHR gene requires tight controls. Several regulatory mechanisms have been found within its 5'-untranslated region (UTR) promoter and coding regions.
View Article and Find Full Text PDFTher Drug Monit
April 2014
*Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto; †Department of Pharmacology and Toxicology, University of Toronto; ‡School of Pharmacy, University of Waterloo; §McGill University Health Centre-Montreal Children's Hospital Research Institute; and ¶Ivey Chair in Molecular Toxicology, University of Western Ontario, London, Canada.
Background: Polybrominated diphenyl ethers (PBDEs) are chemicals that are added to a variety of consumer products as flame-retardants and have been classified as emerging endocrine disruptors. They are persistent and have been detected in humans. Previous studies have suggested that hair is a suitable matrix for examining human exposure to organic pollutants such as PBDEs.
View Article and Find Full Text PDFPediatr Neurosurg
July 2012
Department of Neurosurgery, McGill University Health Centre/Montreal Children's Hospital, Montréal, Québec, Canada.
Background: Atypical teratoid/rhabdoid tumor (AT/RT) is an aggressive malignant brain tumor that, since it was first identified, has been treated with aggressive treatment regimens, e.g. high-dose chemotherapy with stem cell rescue and early radiotherapy.
View Article and Find Full Text PDFPaediatr Anaesth
July 2011
Department of Pediatric Anesthesia, McGill University Health Centre/Montreal Children's Hospital, Montreal, QC, Canada.
Adenotonsillectomy is the mainstay of treatment for pediatric obstructive sleep apnea syndrome (OSAS). However, there is evidence that the child with severe OSAS is at increased risk of respiratory compromise. The most difficult risk factor to assess is the severity of OSAS, and these difficulties are reviewed.
View Article and Find Full Text PDFMol Endocrinol
March 2009
McGill University Health Centre-Montreal Children's Hospital Research Institute, 4060 St. Catherine West, Room 415-1, Montreal, Quebec, Canada H3Z 2Z3.
The V2 transcript is the major ubiquitously expressed human GH receptor (hGHR) mRNA in all tissues examined to date. In a previous investigation, we defined the V2 promoter as TATA-less and exhibiting many characteristics of a housekeeping gene promoter. We also demonstrated that its basal activity is determined by several different cis-regulatory regions within both the promoter and the V2 exon.
View Article and Find Full Text PDFAm J Med Genet A
September 2008
F. Clarke Fraser Clinical Genetics Unit, Division of Medical Genetics, McGill University Health Centre/Montreal Children's Hospital, Montreal, Quebec, Canada.
Dejerine-Sottas disease (DSD) is a particular phenotype of the Charcot-Marie-Tooth (CMT) disease spectrum that is genetically heterogeneous. It represents a severe form of hypertrophic axonal and demyelinating neuropathy. Although it is predominantly inherited as an autosomal recessive condition, autosomal dominant inheritance has also been described.
View Article and Find Full Text PDFMol Endocrinol
February 2008
McGill University Health Centre-Montreal Children's Hospital Research Institute, 4060 St Catherine West, Montreal, Quebec, Canada.
Human (h) GH plays an essential role in growth and metabolism, and its effectiveness is modulated by the availability of its specific receptor [hGH receptor (hGHR)] on target cells. The hGHR gene has a complex 5'-regulatory region containing multiple first exons. Seven are clustered within two small regions: V2,V3,V9 (module A) and V1,V4,V7,V8 (module B).
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