36 results match your criteria: "McGill University Health Centre-Montreal Children's Hospital[Affiliation]"

Article Synopsis
  • Compromised heart function and high pulmonary vascular resistance are common in neonates treated with therapeutic hypothermia for hypoxic-ischemic encephalopathy, but limited data exist on heart health post-NICU discharge.
  • An evaluation of 70 neonates showed those with initial abnormal aEEG profiles had significantly reduced right ventricular strain and contraction compared to those with normal aEEG, suggesting ongoing cardiac issues.
  • The findings stress the importance of long-term cardiovascular monitoring in these infants to better understand their health outcomes beyond their initial treatment.
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Endoplasmic Reticulum Stress Delays Choroid Development in the HCAR1 Knockout Mouse.

Am J Pathol

December 2024

Program in Biomedical Science, Faculty of Medicine, Université de Montreal, Montreal, Quebec, Canada; Department of Pediatrics, Ophthalmology and Pharmacology, Centre de Recherche du CHU Sainte-Justine, Montréal, Quebec, Canada; School of Optometry, Université de Montréal, Montreal, Quebec, Canada. Electronic address:

The subretina, composed of the choroid and the retinal pigment epithelium (RPE), plays a critical role in proper vision. In addition to phagocytosis of photoreceptor debris, the RPE shuttles oxygen and nutrients to the neuroretina. For their own energy production, RPE cells mainly rely on lactate, a major by-product of glycolysis.

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Purpose Of Review: Pulmonary hypertension (PH) is commonly observed in premature infants with bronchopulmonary dysplasia (BPD) and is associated with poor outcomes and increased mortality. This review explores the management of this intricate condition of the pulmonary vasculature, which exhibits heterogeneous effects and may involve both arterial and postcapillary components.

Recent Findings: Current management of BPD-PH should focus on optimizing ventilatory support, which involves treatment of underlying lung disease, transitioning to a chronic phase ventilation strategy and evaluation of the airway.

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Article Synopsis
  • The study aimed to identify specific fetal echocardiography markers that can accurately predict coarctation of the aorta (CoA) in newborns, as current diagnostic methods have a high rate of false positives.
  • Researchers conducted a retrospective case-control study comparing various echocardiographic measurements of infants who required treatment for CoA after birth with those who did not, stratifying results based on gestational age (GA).
  • Results showed that specific ratios of right to left ventricular dimensions and deformation parameters are the most effective predictors of true CoA, particularly the RV/LV end-diastolic area ratio, which identified all cases of CoA with a high sensitivity.
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Provincial Review of Adherence to Age-specific Guidelines for Umbilical Hernia Repair and Trends in Management.

J Pediatr Surg

May 2024

Harvey E. Beardmore Division of Pediatric Surgery, Department of Pediatric Surgery, McGill University Health Center, Montreal Children's Hospital, Canada. Electronic address:

Background: Umbilical hernia (UH) is a common pediatric condition, for which delaying surgical repair for asymptomatic UH until after age 3 is recommended due to a high incidence of spontaneous closure. We aimed to determine the adherence to guidelines, rate of urgent surgical repair, outcomes, cost, and interinstitutional referral patterns of UH repair in the province of Quebec (Canada).

Methods: This was a population-based retrospective cohort study of children 28 days to 17 years old who underwent UH repair between 2010 and 2020 using health administrative databases.

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Article Synopsis
  • - The study investigated how early cardiac function impacts outcomes like death and severe bronchopulmonary dysplasia (BPD) in extremely premature infants born before 29 weeks, through a retrospective analysis of 176 infants from 2015 to 2019.
  • - Findings revealed that infants who experienced death/severe BPD had lower birth weights and showed reduced heart function on echocardiograms taken within 21 days, with specific measurements indicating worse cardiac performance and potential pulmonary issues.
  • - The research concluded that diminished cardiac function early in life correlates with increased risks of severe BPD and related pulmonary hypertension, suggesting the importance of monitoring heart health in neonates and its potential role in predicting outcomes.
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The electroretinogram (ERG) represents the biopotential evoked by the retina in response to a light stimulus. The flash evoked ERG (fERG) is the ERG modality most frequently used clinically to diagnose and monitor retinal disorders. We hereby present a new method to record spontaneous retinal activity, without the use of a flash stimulus, that we named the resting-state ERG (rsERG).

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Article Synopsis
  • The study aimed to assess the factors linked to significant pulmonary hypertension (PH) in infants born prematurely and how it affects their heart function at 36 weeks postmenstrual age (PMA).
  • Out of 387 infants, 222 were studied, with 24 (11%) showing significant PH, which was linked to lower heart function metrics, including reduced tricuspid annular plane systolic excursion and peak longitudinal strain in both the right and left ventricles.
  • The results indicate that premature infants with significant PH experience changes in heart function affecting both sides of the heart, highlighting a deeper cardiac issue related to their PH condition.
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Article Synopsis
  • The study aimed to assess the spontaneous closure of patent ductus arteriosus (PDA) in extremely preterm infants, particularly those born before 26 weeks gestational age, and its impact on their respiratory health.
  • A retrospective analysis was conducted on 214 extremely preterm infants admitted shortly after birth, with significant findings showing that 91% experienced spontaneous PDA closure, including 90% of those <26 weeks.
  • The results indicated not only high closure rates by term corrected age but also a notable reduction in occurrences of moderate-to-severe bronchopulmonary dysplasia over the study period.
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Continuous and Daily Oral Immunotherapy for Peanut Allergy: Results from a 2-Year Open-Label Follow-On Study.

J Allergy Clin Immunol Pract

May 2021

Aimmune Therapeutics, Brisbane, Calif; Department of Medicine, University of California San Francisco, San Francisco, Calif. Electronic address:

Article Synopsis
  • The ARC004 study explored the long-term effects and various dosing regimens of daily oral immunotherapy with Peanut allergen powder (PTAH) in peanut-allergic children and adolescents, following positive results from the PALISADE trial.
  • A total of 358 participants, both those who had continued from the PALISADE trial and new participants, underwent different daily or non-daily dosing strategies, with safety and efficacy being assessed.
  • Results indicated that daily dosing led to higher desensitization rates with sustained safety, and the immune response continued to show signs of improvement in participants over the course of the study.
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Purpose: It has been suggested that retinal blood vessel arborization (RBVA) is unique to each individual. We examined this claim in a pedigree that included two pairs of monozygotic twins.

Methods: Fundus photographs were taken of subjects belonging to this pedigree to compare the pattern of their RBVA.

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The effects of bandpass filtering on the oscillatory potentials of the electroretinogram.

Doc Ophthalmol

June 2019

Department of Ophthalmology and Neurology-Neurosurgery, Research Institute of the McGill University Health Centre/Montreal Children's Hospital, 1001 Boul. Décarie, Glen Site, Block E, Program Mail Drop Point #EM03211 - Office #EM03238, Montréal, QC, H4A 3J1, Canada.

Purpose: In order to study the OPs, the ERG signal must be filtered to eliminate the low-frequency waves known as the a- and b-waves. Unfortunately, the ISCEV ERG standard does not give clear guidelines on how to proceed apart from indicating that frequencies below 75 Hz should be filtered out when recording scotopic OPs, while no suggestions are offered for the photopic OPs. The purpose of this study was thus to characterize more extensively the effects of various digital filters on the photopic OP waveforms in order to suggest the most appropriate filtering method to record them.

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Inactivating mutations in SMARCA4 (BRG1), a key SWI/SNF chromatin remodelling gene, underlie small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). To reveal its druggable vulnerabilities, we perform kinase-focused RNAi screens and uncover that SMARCA4-deficient SCCOHT cells are highly sensitive to the inhibition of cyclin-dependent kinase 4/6 (CDK4/6). SMARCA4 loss causes profound downregulation of cyclin D1, which limits CDK4/6 kinase activity in SCCOHT cells and leads to in vitro and in vivo susceptibility to CDK4/6 inhibitors.

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Recording and Analysis of the Human Clinical Electroretinogram.

Methods Mol Biol

July 2018

Department of Ophthalmology & Neurology-Neurosurgery, Research Institute of the McGill University Health Centre/Montreal Children's Hospital, 1001 Boul. Décarie, Glen Site, Block E, Montreal, QC, Canada, H4A 3J1.

The electroretinogram (ERG) represents the biopotential that is produced by the retina in response to a light stimulus. To date, it remains the best diagnostic tool to objectively evaluate the functional integrity of the normal or diseased retina. In the following pages we briefly review the necessary requirements in order to record and analyze the conventional clinical ERG.

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Purpose: Although the DTL fiber electrode has been in use in the ERG field for more than four decades, its composition was never clearly defined. We compared five different types of conductive (DTL type) yarn (differing in terms of mass, number of filaments, and crimping degree) in order to determine whether we could identify one that would be better suited for the recording of ERGs.

Methods: Photopic flash ERGs were recorded from five subjects using the following DTL electrodes: 27/7, 22/1, 11/1, 11/1*2, and 22/1*2.

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Purpose: Discrete wavelet transform (DWT) analyses suggest that the 20- and 40-Hz components of the short-flash photopic electroretinogram (ERG) are closely related to the ON and OFF pathways, respectively. With the DWT, we examined how the ERG ON and OFF components are modulated by the stimulus intensity and/or duration.

Methods: Discrete wavelet transform descriptors (20, 40 Hz and 40:20-Hz ratio) were extracted from ERGs evoked to 25 combinations of flash durations (150-5 ms) and strengths (0.

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Traumatic brain injury in a rural indigenous population in Canada: a community-based approach to surveillance.

CMAJ Open

July 2016

Department of Epidemiology, Biostatistics and Occupational Health (Lasry, Fuhrer), McGill University, Montréal, Que.; Department of Neurosurgery (Lasry, Marcoux), McGill University Health Centre - Montréal General Hospital, Montréal, Qué.; Department of Surgery (Dudley), Division of Neurosurgery, McGill University Health Centre - Montréal Children's Hospital, Montréal, Qué.; Department of Public Health (Torrie), Cree Board of Health and Social Services of James Bay, Mistissini, Qué.; Department of Public Health (Carlin), Cree Board of Health and Social Services of James Bay, Montréal, Qué.

Background: Indigenous populations are disproportionately affected by traumatic brain injury. These populations rely on large jurisdiction surveillance efforts to inform their prevention strategies, which may not address their needs. We examined the incidence and determinants of traumatic brain injury in an indigenous population in the Terres-Cries-de-la-Baie-James health region of the province of Quebec and compared them with the incidence and determinants in 2 neighbouring health regions and in the province overall.

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Regulation of human growth hormone receptor expression by microRNAs.

Mol Endocrinol

September 2014

Departments of Experimental Medicine (S.E., C.G.G.) and Pediatrics (C.G.G.), McGill University, and Endocrine Research Laboratory (S.E., C.G.G.), Research Institute of McGill University Health Centre-Montreal Children's Hospital, Montreal, Quebec, Canada H3Z 2Z3.

Human GH binds to its receptor (GHR) on target cells and activates multiple intracellular pathways, leading to changes in gene expression, differentiation, and metabolism. GHR deficiency is associated with growth and metabolic disorders whereas increased GHR expression has been reported in certain cancers, suggesting that the GHR gene requires tight controls. Several regulatory mechanisms have been found within its 5'-untranslated region (UTR) promoter and coding regions.

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Investigating the use of hair to assess polybrominated diphenyl ether exposure retrospectively.

Ther Drug Monit

April 2014

*Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto; †Department of Pharmacology and Toxicology, University of Toronto; ‡School of Pharmacy, University of Waterloo; §McGill University Health Centre-Montreal Children's Hospital Research Institute; and ¶Ivey Chair in Molecular Toxicology, University of Western Ontario, London, Canada.

Background: Polybrominated diphenyl ethers (PBDEs) are chemicals that are added to a variety of consumer products as flame-retardants and have been classified as emerging endocrine disruptors. They are persistent and have been detected in humans. Previous studies have suggested that hair is a suitable matrix for examining human exposure to organic pollutants such as PBDEs.

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Background: Atypical teratoid/rhabdoid tumor (AT/RT) is an aggressive malignant brain tumor that, since it was first identified, has been treated with aggressive treatment regimens, e.g. high-dose chemotherapy with stem cell rescue and early radiotherapy.

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Adenotonsillectomy is the mainstay of treatment for pediatric obstructive sleep apnea syndrome (OSAS). However, there is evidence that the child with severe OSAS is at increased risk of respiratory compromise. The most difficult risk factor to assess is the severity of OSAS, and these difficulties are reviewed.

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The V2 transcript is the major ubiquitously expressed human GH receptor (hGHR) mRNA in all tissues examined to date. In a previous investigation, we defined the V2 promoter as TATA-less and exhibiting many characteristics of a housekeeping gene promoter. We also demonstrated that its basal activity is determined by several different cis-regulatory regions within both the promoter and the V2 exon.

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Dejerine-Sottas disease (DSD) is a particular phenotype of the Charcot-Marie-Tooth (CMT) disease spectrum that is genetically heterogeneous. It represents a severe form of hypertrophic axonal and demyelinating neuropathy. Although it is predominantly inherited as an autosomal recessive condition, autosomal dominant inheritance has also been described.

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Human (h) GH plays an essential role in growth and metabolism, and its effectiveness is modulated by the availability of its specific receptor [hGH receptor (hGHR)] on target cells. The hGHR gene has a complex 5'-regulatory region containing multiple first exons. Seven are clustered within two small regions: V2,V3,V9 (module A) and V1,V4,V7,V8 (module B).

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