14,031 results match your criteria: "McGill University Health Centre[Affiliation]"

Objective: We investigated strategies to mitigate hypoglycemic risk during and after different aerobic exercises in people with type 1 diabetes (pwT1D) using continuous subcutaneous insulin infusion.

Research Design And Methods: Thirty-seven pwT1D (21 adults, 16 adolescents; HbA1c = 7.5 ± 1.

View Article and Find Full Text PDF

Introduction: Castleman disease (CD) is a rare lymphoproliferative disorder having a variegated clinical presentation. Diagnosis of the idiopathic HIV- and HHV8-negative multicentric CD (iMCD) subtype poses a challenge given its non-specific clinical manifestations. iMCD presents as diffuse lymphadenopathy with inflammatory manifestations, primarily driven by interleukin-6 (IL-6).

View Article and Find Full Text PDF

Aim: To conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) that investigated the effectiveness of tranexamic acid (TXA) among patients undergoing arthroscopic rotator cuff repair (ARCR).

Methods: Five databases were screened until December 18, 2022. The included RCTs were assessed for risk of bias, and the endpoints were summarized as mean difference/standardized mean difference (MD/SMD) or risk ratio (RR) with the 95% confidence interval (CI) in a random-effects model.

View Article and Find Full Text PDF

Why and When Do We Invasively Restage After Neoadjuvant Chemoimmunotherapy?

J Thorac Oncol

December 2024

Scientific Affairs, International Association for the Study of Lung Cancer, Denver, Colorado.

View Article and Find Full Text PDF

Changing public health and hospital protocols during the height of the COVID-19 pandemic shaped the provision of inpatient mental health care. While a growing body of research explores the challenges of restrictions on adult psychiatric wards, the impact on clinical teams and epidemiological trends in youth mental health, no research has explored inpatient psychiatric hospital services for child and adolescent psychiatry during the pandemic. This study seeks to understand how clinicians in Canada working in child and adolescent mental health wards experienced caring for their patients while navigating pandemic hospital restrictions.

View Article and Find Full Text PDF

Understanding Strategies to Reduce the Impact of Non-urgent Visits to the Pediatric Emergency Department: A Scoping Review.

Pediatr Emerg Care

December 2024

Montreal Children's Hospital, Division of Pediatric Emergency Medicine, McGill University Health Centre, and the Department of Biostatistics, Epidemiology and Occupational Health, McGill University, Montreal, Quebec.

Context: The pediatric emergency department (PED) is increasingly being used for non-urgent reasons. This impacts PED input and throughput, and contributes to overcrowding. To identify solutions, it is essential to identify and describe the approaches that have been trialed.

View Article and Find Full Text PDF

Advancing research on parasitic infections: Standardized extracellular vesicle guideline.

J Extracell Vesicles

December 2024

Instituto de Ciências Ambientais, Químicas e Farmacêuticas; Departamento de Ciências Farmacêuticas; Laboratório de Imunologia Celular e Bioquímica de Fungos e Protozoários. Departamento de Ciências Farmacêuticas, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, Brazil.

View Article and Find Full Text PDF

Extreme LDL-C concentration is associated with increased cardiovascular disease in women with homozygous familial hypercholesterolemia.

J Clin Lipidol

November 2024

Lipids, Nutrition, and Cardiovascular Prevention Clinic of the Montreal Clinical Research Institute, Montreal, Québec, Canada; Department of Medicine, Divisions of Experimental Medicine and Medical Biochemistry, McGill University, Montreal, Québec H3G 2M1, Canada. Electronic address:

Background: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disease of low-density lipoprotein cholesterol (LDL-C) metabolism. Despite the devastating effect of this disease on atherosclerotic cardiovascular health, the disease phenotype and severity are more heterogeneous than previously thought. The predictors of atherosclerotic cardiovascular disease (ASCVD) in HoFH patients have never been systematically studied.

View Article and Find Full Text PDF

Guiding drug provocation testing for ibuprofen hypersensitivity in a pediatric population: Development of the I3A risk-stratification tool.

J Allergy Clin Immunol Pract

December 2024

The Research Institute of the McGill University Health Centre, McGill University, McGill University Health Centre (MUHC), Montreal, Quebec, Canada; Division of Pediatric Allergy and Clinical Immunology, Department of Medicine, McGill University Health Center (MUHC), McGill University, Montreal, Quebec, Canada.

Article Synopsis
View Article and Find Full Text PDF

Background: This study aimed to develop an organizational typology of Interprofessional Primary Care (IPC) teams in Quebec, Canada, by describing their organizational profiles and assessing the association between the characteristics of the populations served and the organizational profiles.

Methods: This cross-sectional study was carried out using a finite mixture model of the 2021 financial monitoring data from the Ministry of Health and Social Services of Quebec. The population consisted of all IPC teams in Quebec (N = 368).

View Article and Find Full Text PDF
Article Synopsis
  • - The study examines the effectiveness of a treatment strategy combining neoadjuvant chemotherapy (NECTORS) followed by surgery in preventing distant metastasis (DM) in patients with HPV-related oropharyngeal cancer, compared to standard care with concurrent chemoradiation (CCRT).
  • - It includes 342 patients with advanced HPV-positive OPSCC, showing that NECTORS resulted in no cases of distant-only metastasis and fewer overall recurrences than CCRT.
  • - The analysis considers various factors like age, sex, and cancer stage to assess DM-free survival rates, highlighting the potential benefits of NECTORS in reducing treatment-related toxicity.
View Article and Find Full Text PDF
Article Synopsis
  • * In a study with Balb/c mice, both male and female mice exhibited increased ILC2s after exposure to IL-33, but females expressed higher levels of important receptors (ST2 and IL-25R) linked to immune responses.
  • * The enhanced type 2 inflammation seen in females is tied to specific ILC2 subsets that have a stronger response capability due to changes driven by the STAT6 pathway, particularly during secondary activation by epithelial-derived cytokines.
View Article and Find Full Text PDF

Neurological injury drives most deaths and morbidity among patients hospitalized for out-of-hospital cardiac arrest (OHCA). Despite its clinical importance, there are no effective pharmacological therapies targeting post-cardiac arrest (CA) neurological injury. Here, we analyzed circulating immune cells from a large cohort of patients with OHCA, finding that lymphopenia independently associated with poor neurological outcomes.

View Article and Find Full Text PDF

Background: Reflex molecular testing, the process of profiling specimens at diagnosis, is emerging in oncology, allowing for prompt therapy initiation, and potentially improving outcomes. This study evaluates the impact of reflex BRAF testing on treatment timelines and outcomes in melanoma, lung and colorectal cancers at the McGill University Health Center (MUHC).

Methods: A retrospective chart review was conducted at the MUHC.

View Article and Find Full Text PDF
Article Synopsis
  • The study analyzes data from the Kids-DOTT trial to investigate the treatment and outcomes of children with cerebral sinovenous thrombosis (CSVT) compared to those with other types of venous thromboembolism (VTE).
  • CSVT was found to be more common in neonates and young children, often linked to infections, while treatment involved varying durations of anticoagulation, with no significant difference in outcomes between 6 weeks and longer treatments.
  • The findings suggest that 6 weeks of anticoagulant therapy is safe and effective for treating acute pediatric CSVT, but caution is advised in generalizing results due to the nature of subgroup analysis.
View Article and Find Full Text PDF

Background: Penicillin allergy labels are associated with many adverse outcomes. Fear and restriction of future medication use also have an impact on health-related quality of life (HR-QoL). However, the impact of a drug allergy on HR-QoL and its associated factors remains unknown.

View Article and Find Full Text PDF