2 results match your criteria: "McGill University H3A 2B4[Affiliation]"
A comprehensive update of siRNA delivery design strategies for targeted and effective gene silencing in gene therapy and other applications.
Expert Opin Drug Discov
February 2023
Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering, Faculty of Medicine, McGill University H3A 2B4, Montreal, Quebec, Canada.
Article Synopsis
- RNA interference (RNAi) using small interfering RNA (siRNA) shows promise for treating genetic disorders but faces significant delivery challenges due to various barriers.
- Strategies to enhance siRNA delivery include chemical modifications, bioconjugation with ligands, and nanotechnology-based systems like liposomes and nanoparticles.
- Despite the established mechanism of siRNA as a gene silencer, effective therapeutic products remain limited, and there's an urgent need for improved delivery systems to target specific sites for treating diseases early on.
Rapid and multiplex detection of Legionella's RNA using digital microfluidics.
Lab Chip
March 2015
3775 University Street, Department of Biomedical Engineering, Faculty of Medicine, McGill University H3A 2B4, Montreal, (QC), Canada.
Despite recent advances in the miniaturization and automation of biosensors, technologies for on-site monitoring of environmental water are still at an early stage of development. Prevention of outbreaks caused by pathogens such as Legionella pneumophila would be facilitated by the development of sensitive and specific bioanalytical assays that can be easily integrated in miniaturized fluidic handling systems. In this work, we report on the integration of an amplification-free assay in digital microfluidics (DMF) for the detection of Legionella bacteria based on targeting 16s rRNA.
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