Molecular detection of DNA in wild-caught sand flies, and spp. in northern Iran.

Leishmaniasis is currently considered a major health problem in Iran, posing an increasing threat to society's development in various dimensions. This study aimed to detect infection in wild-caught sand flies in Sari City, northern Iran. Sand flies were collected using sticky traps, and DNA was identified using polymerase chain reaction (PCR) targeting the ITS2-rDNA region, followed by restriction fragment length polymorphism (RFLP) analysis.

Exosomes derived from human placental mesenchymal stem cells in combination with hyperbaric oxygen therapy enhance neuroregeneration in a rat model of sciatic nerve crush injury.

Peripheral nerve damage continues to be a significant challenge in the field of medicine, with no currently available effective treatment. Currently, we investigated the beneficial effects of human placenta mesenchymal stem cells (PMSCs)- derived exosomes along with hyperbaric oxygen therapy (HBOT) in a sciatic nerve injury model. Seventy-five male mature Sprague-Dawley rats were allocated into five equal groups.

The Role of Plzf in Spermatogonial Stem Cell Maintenance and Differentiation: Mapping the Transcriptional Dynamics and Key Interactions.

Spermatogonial stem cells (SSCs) sustain and modulate spermatogenesis through intricate signaling pathways and transcription factors. Promyelocytic leukemia zinc-finger (, also known as ) has been identified as a critical transcription factor influencing various signaling and differentiation pathways. plays a pivotal role in regulating the differentiation properties of SSCs and is essential for the proper maintenance of spermatogenesis.

Electrochemical biosensors for depression: Diagnosis and therapeutic monitoring.

Electrochemical biosensors have revolutionized the detection of biomarkers related to depression and the quantification of antidepressant drugs. These biosensors leverage nanomaterials and advanced assay designs to achieve high sensitivity and selectivity for clinically relevant analytes. Key neurotransmitters implicated in depression, such as serotonin, dopamine, and glutamate, can be accurately measured via biosensors, providing insights into the effects of antidepressant treatments on neurotransmission.

Effect of hypnosis on anxiety and blood pressure of pregnant women with preeclampsia: A double-blind controlled clinical trial study.

Background: The risk is on the level of blood pressure, and blood pressure is one of the prominent characteristics of preeclampsia. The aim of this study is to assess the effect of hypnosis on the pressure and blood pressure of pregnant women with preeclampsia.

Materials And Methods: In this controlled clinical trial study, 44 pregnant women from 20 to 32 weeks referred to Shahid Akbarabadi Hospital in Tehran in 2022 were randomly assigned to two intervention and control groups.

The Long-Term Journey of a Tuberculosis Patient With Triple Organ Involvement and Rheumatological Disease: A Case Study and Literature Review.

Tuberculosis (TB) is an infectious disease caused by bacteria, which is more prevalent among immunocompromised individuals. According to the distribution of affected organs, this infection can be categorized as either pulmonary or extrapulmonary TB. Immunodeficiency states resulting from rheumatological disorders and the use of immunosuppressive medications, such as in Behçet's disease (BD), are potential predisposing factors for TB, particularly in cases involving multiple organs.

The emerging role of TIM-3 in colorectal cancer: a promising target for immunotherapy.

Introduction: Colorectal cancer (CRC) imposes a substantial worldwide health burden, necessitating innovative strategies to enhance therapeutic outcomes. T cell immunoglobulin-3 (Tim-3), an immune checkpoint, enhances immunological tolerance. Tim-3's role in CRC surpasses its conventional function as an indicator of dysfunction in T lymphocytes.

Assessing cigarette butt pollution on recreational beaches: A comparative study of two sampling methods and their impact on metal release.

Discarded cigarette butts (CBs) are a significant source of environmental pollution. In areas with large amounts of cigarette waste, environmental hazards may arise due to the leaching of chemicals from filters and smoked tobacco. Accurately estimating the number of CBs on beaches requires a standardized method.

Comparative efficacy and safety of therapeutic strategies for mirror aneurysms: A systematic review and meta-analysis.

Mirror aneurysms are rare and pose therapeutic challenges, with both endovascular and microsurgical options available. Single-stage and two-stage procedures are employed, but the optimal strategy remains unclear. This systematic review and meta-analysis evaluate the efficacy and safety of different therapeutic strategies for managing mirror aneurysms.

Rhazes' insights on abortion and abortogenic drugs in relation to modern concepts.

Abortion remains one of the most prevalent complications of pregnancy, contributing significantly to maternal mortality and presenting a substantial public health challenge. This study aimed to explore Rhazes' perspective on abortion and abortifacient medicinal plants he mentioned in Kitāb al-Ḥāwī fī al-Ṭibb. A detailed analysis of his seminal work, Kitāb al-Ḥāwī fī al-Ṭibb, was conducted.

Open surgery for carpal tunnel syndrome: is it necessary to release the antebrachial fascia? A randomized clinical trial study.

Background: Open surgery for carpal tunnel syndrome (CTS) has historically involved release of the antebrachial fascia. The benefit of antebrachial fascia release in CTS surgery is still controversial. So, this study was designed to evaluate this hypothesis.

Combination Effect of Phenylalanine-Arginine-Beta-Naphthylamide and Curcumin on the Expression of the Gene in Aminoglycoside-Resistant Clinical Isolates of .

Background And Aims: Overexpression of MexXY-OprM efflux pump causes resistance to aminoglycosides in . We aimed to investigate the relationship between resistance to aminoglycosides and the MexXY-OprM expression level in clinical isolates without and after treatment with curcumin and/or phenylalanine-arginine-beta-naphthylamide (PAβN) as the efflux pump inhibitors.

Methods: We collected 100 clinical isolates from hospitalized patients.

Reassessing Ivabradine: Potential Benefits and Risks in Atrial Fibrillation Therapy.

Background: Ivabradine has been identified as a funny current (If) inhibitor in the sinoatrial node (SAN) and is considered an advocated therapeutic agent in chronic heart failure and stable angina. This therapeutic agent has shown positive benefits in maintaining a reduction in heart rate while sustaining hemodynamic stability. Its clinical application is still evolving and the mechanism of action is becoming clearer daily.

Fat embolism syndrome following femoral shaft fracture: A case report and diagnostic considerations.

Fat embolism syndrome (FES) is a rare but serious complication that can arise after long bone fractures or orthopedic surgeries. This case report presents a 40-year-old male who developed FES following surgical fixation of a femoral shaft fracture using 2 plates. The day after surgery, the patient exhibited tachycardia, respiratory distress, and a fever of 38.

Peptide-based inhibitors and nanoparticles: Emerging therapeutics for Alzheimer's disease.

Alzheimer's disease (AD) is an age-related progressive neurodegenerative disorder characterized by memory loss, cognitive decline, and behavioral changes, impacting millions of individuals worldwide. Despite significant research into its cellular and molecular mechanisms, no cure has been found to treat AD to date. For over two decades, research aimed at treating AD has focused on targeting amyloid-β (Aβ); however, these strategies have not demonstrated substantial effectiveness.

The clinico-epidemiological, diagnostic, and therapeutic aspects of methadone poisoning: a registry-based clinical study.

Objectives: Methadone is a long-acting synthetic agonist of opioid receptors, which is used as an analgesic and as an alternative treatment in opioid-dependent patients. Clinical manifestations of methadone poisoning include miotic pupils, low levels of consciousness (LOC), respiratory depression or apnea, and coma and death. Considering the high consumption of methadone in society and the prevalent instances of overdose and poisoning, whether accidental or intentional, the authors decided to investigate the clinico-epidemiological, diagnostic, and therapeutic characteristics of methadone poisoning in the Mazandaran province, northern Iran, from 2020 to 2022.

Prevalence of Fungal Infections in Pemphigus Patients: A Systematic Review and Meta-Analysis.

Background: Pemphigus is a life-threatening autoimmune disease characterised by blistering skin and/or mucous membranes. The present study aimed to determine the prevalence of fungal infections in the pemphigus population.

Methods: Different databases were searched to gain access to all studies on the prevalence of fungal infections published up to the 31st of May 2024.

Lutein improves remyelination by reducing of neuroinflammation in C57BL/6 mouse models of multiple sclerosis.

Multiple sclerosis (MS) is an inflammatory neurodegenerative disorder characterized by demyelination. Lutein, a xanthophyll carotenoid, has well-known antioxidant and anti-inflammatory properties. In this experiment, we aimed to investigate the neuroprotective and remyelination potential of lutein in comparison with dimethyl fumarate (DMF) as a reference drug in post-cuprizone-intoxicated C57BL/6 mice.

Alterations in the expression of serum-derived exosome-enclosed inflammatory microRNAs in Covid-19 patients.

Introduction: MicroRNAs in exosomes play a role in biological processes such as inflammation and Epithelial-mesenchymal transition (EMT). In EMT, epithelial cells undergo phenotypic changes and become similar to mesenchymal cells. EMT increases the invasion and metastasis of cancer cells.

Genetic Variants and Haplotype Structures in the Gene Family to Predict Cancer Risk: A Bioinformatics Study.

Background And Aims: The cancer susceptibility () gene family of long noncoding RNAs (lncRNAs) plays an important role in cancer. The aim of this study was to identify genetic variants and haplotype structures of genes associated with cancer risk.

Methods: Genome-wide association studies (GWAS) significant variants ( ≤ 5 × 10) on family genes were identified from the GWAS Catalog-EMBL-EBI, and then cancer-associated variants on genes were extracted.

The Effect of Dexmedetomidine on Inflammatory Factors and Clinical Outcomes in Patients With Septic Shock: A Randomized Clinical Trial.

Purpose: Dexmedetomidine is a sedative-analgesic that is widely used in sepsis. However, its effect on septic shock remains unclear. This study aimed to investigate dexmedetomidine's effect on inflammatory biomarkers in septic shock.

Psychometrics evaluation of the Persian version of Attitudes toward Patient Safety Questionnaire (APSQ-III) in nursing students.

Background: The topic of patient safety and attitudes toward patient safety among health professionals is a main priority of healthcare systems globally. This study aims to investigate the psychometric properties of APSQ-III among Iranian nursing students.

Methods: There were 307 undergraduate nursing students who participated in the cross-sectional methodological study, from December 2022 to January 2023.