4,198 results match your criteria: "Mayo Clinic Rochester.[Affiliation]"
Article Synopsis
- Pulsed-field ablation (PFA) is a new technique for treating atrial fibrillation (AF) that targets heart tissue more selectively than traditional thermal methods like radiofrequency and cryoablation.
- A systematic review of 17 studies with 2,255 patients found that PFA significantly lowers AF recurrence, procedure time, heart rate changes, and risks of certain complications like phrenic nerve palsy and esophageal lesions.
- However, PFA is also linked to a higher risk of pericardial tamponade, indicating it has both benefits and potential risks compared to thermal ablation.
Dementia risk reduction between DOACs and VKAs in AF: A systematic review and meta-analysis.
J Arrhythm
October 2024
Intermountain Heart Institute, Utah Valley Hospital Provo Utah USA.
Introduction: Direct oral anticoagulants (DOACs) become the recommended treatment over vitamin K antagonists (VKA) in patients with non-valvular atrial fibrillation (AF). However, their effectiveness in reducing cognitive impairment and dementia compared to VKA remains unclear.
Methods: A systematic literature search was conducted on Ovid MEDLINE, EMBASE, and Cochrane Database.
Article Synopsis
- The study investigates the combination of venetoclax (VEN) and vincristine (L-VCR) for patients with relapsed or refractory acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma (LL).
- In a dose escalation trial with 18 patients, the maximum tolerated dose (MTD) of the drug combination was determined to be VEN at 600 mg, with significant adverse events reported in 89% of participants.
- The preliminary results showed a 22% complete response rate, with some patients achieving no measurable residual disease, indicating potential efficacy for this treatment approach.
Article Synopsis
- Chronic lymphocytic leukemia (CLL) varies greatly among patients, with some experiencing slow progression and others facing aggressive forms leading to early death.
- A study with 1,154 CLL patients examined how lifestyle and medical history factors before diagnosis influenced the time until first treatment (TTFT), adjusting for the CLL-International Prognostic Index (CLL-IPI).
- Results indicated that the CLL-IPI score was the main factor affecting TTFT, with minimal influence from lifestyle factors, providing reassurance to patients about the limited impact of these factors on their disease progression.
High Ki67 index is associated with shorter progression free survival in patients with Follicular Lymphoma treated with frontline immunochemotherapy.
Leuk Lymphoma
February 2025
Department of Hematologic Oncology and Blood Disorders, Atrium Health Levine Cancer Institute, Charlotte, NC, USA.
EoE Recurrence on PPI Maintenance Therapy: You Do Not Know if You Do Not Look!
Dig Dis Sci
November 2024
Department of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, USA.
Background And Aims: Data regarding histologic recurrence of EoE on PPI maintenance therapy are lacking.
Methods: Retrospective review of 101 patients with histologic PPI-responsive EoE.
Results: 52/101 (51%) patients underwent follow-up EGD with biopsies.
Language-model-based patient embedding using electronic health records facilitates phenotyping, disease forecasting, and progression analysis.
Res Sq
September 2024
Department of Medicine, Division of Biomedical Informatics and Genomics, Tulane University, New Orleans, LA.
Article Synopsis
- Current studies on electronic health records (EHR) using machine learning highlight the need for better patient representation to identify new medical patterns.
- A novel unsupervised method was developed to embed high-dimensional EHR data and successfully predicts disease events and assesses patient diversity in complex diseases.
- Validated on extensive datasets, the approach revealed distinct comorbidity patterns and variations in disease outcomes, demonstrating the effectiveness of representation learning in EHR analysis.
Background: Data from the Centers for Disease Control show that approximately one-quarter of adults have elevated triglyceride (TG) levels. Some clinical trials, but not all, have demonstrated that pharmacologic treatment of high TG levels in patients already on statin therapy reduces the rate of major vascular events such as myocardial infarction and stroke. We assessed the prevalence of elevated TG levels in patients with asymptomatic carotid stenosis (CS), and medical conditions associated with high TG.
View Article and Find Full Text PDFClinical features, hemodynamics, and outcomes of pulmonary hypertension in adults with coarctation of aorta.
Int J Cardiol
January 2025
Department of Cardiovascular Medicine, Mayo Clinic Rochester, MN 55905, USA.
Article Synopsis
- A study investigated pulmonary hypertension (PH) in adults with repaired coarctation of the aorta (COA) and found that 58% of patients had PH, indicating a significant prevalence.
- Among those with PH, 25% had isolated precapillary PH, suggesting vascular dysfunction in the pulmonary artery may contribute to the condition.
- The study highlights the relationship between higher pulmonary artery pressure and increased risk of cardiovascular events and all-cause mortality, emphasizing the need for further research on treatment strategies for PH in this patient population.
The impact of systolic blood pressure reduction on aneurysm re-bleeding in subarachnoid hemorrhage: A systematic review and meta-analysis.
J Stroke Cerebrovasc Dis
December 2024
Department of Neurology, Mayo Clinic Rochester, Rochester, MN, USA. Electronic address:
Article Synopsis
- Preventing rebleeding in aneurysmal subarachnoid hemorrhage (SAH) is important, and lowering systolic blood pressure (SBP) may help, although evidence is not clear-cut.
- A systematic review analyzed ten studies, finding that higher SBP is linked to a greater chance of rebleeding, while maintaining SBP ≤160 mmHg reduced this risk significantly.
- The results should be approached cautiously due to variability in study designs, highlighting the need for more standardized future research to better understand blood pressure's role in rebleeding risk.
Iodine and Gadolinium Contrast Reactions: What Is the Risk and Role of Premedication, Abbreviated Protocols, Prior History of Reactions, and Cross-Reactivity?
Radiol Clin North Am
November 2024
Department of Radiology, Mayo Clinic Rochester, 200 1st Street SW, Rochester, MN 55905, USA.
Article Synopsis
- - Immediate hypersensitivity reactions to iodinated and gadolinium-based contrast media can be seriously dangerous and potentially life-threatening.
- - While corticosteroid premedication and switching agents may help reduce risk, evidence supporting their efficacy is mostly indirect and increasingly challenged by recent studies.
- - Identifying "high-risk" patients is complicated, but a history of previous reactions to the same type of contrast media is the most significant risk factor.
Propofol, Triglycerides, and Acute Pancreatitis: A Multi-Center Epidemiologic Analysis.
Ann Am Thorac Soc
October 2024
Mayo Clinic Division of Pulmonary and Critical Care Medicine, Rochester, Minnesota, United States;
Article Synopsis
- Propofol is frequently used as a sedative for critically ill adults on mechanical ventilation, but its link to elevated triglyceride levels and acute pancreatitis remains unclear.
- The study observed over 11,000 ICU patients receiving propofol, finding that about 21.7% developed hypertriglyceridemia, and those with high triglycerides had a significantly increased risk of pancreatitis.
- Despite the association between triglyceride levels and pancreatitis, acute pancreatitis is rare in this population, suggesting other contributing factors may be involved.
Article Synopsis
- The study investigates the best duration and choice of antiplatelet therapy for patients with acute coronary syndrome after undergoing percutaneous coronary intervention.
- A network meta-analysis was conducted on 32 trials with over 103,000 patients, comparing 12-month dual-antiplatelet therapy (DAPT) with several other strategies, including varying doses and durations.
- The findings suggest that the combination of aspirin and ticagrelor for 3 months, followed by aspirin and clopidogrel, significantly lowers major adverse cardiovascular events compared to other DAPT strategies.
Article Synopsis
- A new simplified method was developed to estimate total subarachnoid hemorrhage volume (SAHV) from noncontrast CT scans in patients with aneurysmal subarachnoid hemorrhage (SAH).
- The study analyzed data from 277 patients and found that the new method provided comparable results to a traditional manual segmentation technique, with no significant differences in outcomes.
- Higher volumes of SAHV were linked to worse clinical outcomes and an increased risk of delayed cerebral ischemia, specifically with volumes greater than 10 mL indicating a higher risk.
Fine Needle Aspiration Cytology of Pancreatoblastoma in Adult/Adolescent Patients, One With Histology Mimicking NUT Carcinoma.
Diagn Cytopathol
February 2025
Department of Pathology and Laboratory Medicine, Henry Ford Hospital, Detroit, Michigan, USA.
Article Synopsis
- Pancreatoblastoma is a rare malignant tumor primarily affecting children, but can occasionally appear in adults, complicating cytologic diagnosis because of its mixed cellular structure and the need for squamoid nests.
- Two patients were studied: one was a 38-year-old male with pancreatic and liver lesions featuring a biphasic malignancy, while the second was a 24-year-old female with a past diagnosis related to Gardner's syndrome, showing atypical cells in lymph nodes.
- The study also included a literature review discussing differential diagnosis and necessary tests for accurate identification of pancreatoblastoma.
A Tale of 102,726 Messages: Characterizing the Modern Urologist's Portal Message Burden After Common Urologic Surgeries.
Urol Pract
January 2025
Department of Urology, Mayo Clinic Arizona, Phoenix, Arizona.
Introduction: We aimed to characterize patient portal messaging use after urologic surgery to identify administrative burden and evaluate postoperative clinical associations.
Methods: Epic was queried for all urologic surgeries performed at the Mayo Clinic enterprise between 2019 and 2022. Data from the highest volume procedures were extracted including patient-generated portal messages to their provider and emergency department (ED) visits within 6 months of surgery.
Early Renal Outcomes Following Heart Transplantation Using Organs Procured After Circulatory Death.
J Am Heart Assoc
October 2024
Cardiology Division Corrigan Minehan Heart Center, Massachusetts General Hospital Boston MA USA.
Background: Transplantation using hearts obtained through donation after circulatory death (DCD) is increasing, but data on recipient renal outcomes are limited.
Methods And Results: Patients at a single institution who underwent heart transplantation using organs procured through DCD or donation after brain death (DBD) from April 2016 to August 2022 were included in this retrospective cohort study. Hemodynamic measures were collected via right heart catheterization performed 1 week after transplantation.
Whole-genome sequencing in 333,100 individuals reveals rare non-coding single variant and aggregate associations with height.
Nat Commun
October 2024
Clinical and Biomedical Sciences, University of Exeter, Exeter, UK.
Article Synopsis
- The study investigates how rare non-coding genetic variations affect complex traits, specifically focusing on human height by analyzing data from over 333,100 individuals across three large datasets.
- Researchers found 29 significant rare variants linked to height, with impacts ranging from a decrease of 7 cm to an increase of 4.7 cm, after considering previously known variants.
- The team also identified specific non-coding variants near key genes associated with height, demonstrating a new method for understanding the effects of rare variants in regulatory regions using whole-genome sequencing.
Imaging of Ischemic Cholangiopathy Following Donation after Circulatory Death Liver Transplant.
Radiographics
November 2024
From the Departments of Radiology (M.Z., M.S., M.Y.) and Gastroenterology and Hepatology (C.J., R.P., B.A.), Mayo Clinic Arizona, 13400 E Shea Blvd, Scottsdale, AZ 85259; Department of Radiology, Mayo Clinic Rochester, Rochester, Minn (S.K.V.); Department of Anatomical Pathology, Singapore General Hospital, Singapore (J.T.L.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Mo (D.R.L., D.H.B.).
Article Synopsis
Education Research: EEG Education in Child Neurology and Neurodevelopmental Disabilities Residencies: A Survey of US and Canadian Program Directors.
Neurol Educ
March 2024
From the Department of Neurology (R.K.), Louisiana State University Health Shreveport, LA; Department of Neurology (I.S.S.), Massachusetts General Hospital, Harvard Medical School, Boston, MA; Department of Neurology (A.H.), CHU Sainte-Justine, Universite de Montreal, Canada; Department of Neurology (C.B.A.), Boston Children's Hospital, Harvard Medical School, Boston, MA; Department of Neurology (E.C.W.), Mayo Clinic Rochester, MN; Department of Neurology (S.B.R.), Vanderbilt University Medical Center Nashville, TN; Department of Clinical Neurophysiology (S.B.), Danish Epilepsy Center, Dianalund and Aarhus University Hospital; Department of Clinical Medicine (S.B.), Aarhus University, Denmark; and Department of Neurology (F.A.N.), Washington University School of Medicine St. Louis, MO.
Background And Objectives: In the United States, many child neurologists (CNs) and neurodevelopmental disability (NDD) specialists who read EEGs in clinical practice had no additional EEG training other than what was received during residency. This practice highlights the importance of ensuring that CN/NDD residents achieve EEG competence before graduation. However, prior survey-based evidence showed that roughly a third of graduating CN residents in the United States do not feel confident interpreting EEGs independently.
View Article and Find Full Text PDFProposed Nutrition Competencies for Medical Students and Physician Trainees: A Consensus Statement.
JAMA Netw Open
September 2024
Accreditation Council for Graduate Medical Education, Chicago, Illinois.
Importance: In 2022, the US House of Representatives passed a bipartisan resolution (House of Representatives Resolution 1118 at the 117th Congress [2021-2022]) calling for meaningful nutrition education for medical trainees. This was prompted by increasing health care spending attributed to the growing prevalence of nutrition-related diseases and the substantial federal funding via Medicare that supports graduate medical education. In March 2023, medical education professional organizations agreed to identify nutrition competencies for medical education.
View Article and Find Full Text PDFObjective: To report the first steps of a project to automate and optimize scheduling of multidisciplinary consultations for patients with longstanding dizziness utilizing artificial intelligence.
Study Design: Retrospective case review.
Setting: Quaternary referral center.
Traumatic Brain Injury.
Neurol Clin
November 2024
Department of Neuropsychology, TIRR Memorial Hermann/UTHealth Houston, 1333 Moursund Street, Houston, TX 77030, USA.
Advances in trauma care have allowed persons with traumatic brain injury to survive at increasingly greater rates. However, they commonly go on to experience complex symptoms including changes in cognitive, emotional, and behavioral functioning that together limit functioning and quality of life. Clinical neuropsychology is uniquely skilled to work together with other rehabilitation professionals, using a patient centered approach, evidence-based treatments, and increasingly using emerging technology while adhering to ethical principles of respect, beneficence, and justice.
View Article and Find Full Text PDFIntroduction: Delay in diagnosis of posterior cortical atrophy (PCA) syndrome is common, and the lack of familiarity with assessment tools for identifying visual cortical dysfunction is a contributing factor. We propose recommendations for the approach to the evaluation of PCA clinical features during the office visit, the neuropsychological evaluation, and the research setting. A recommended screening battery for eye clinics is also proposed.
View Article and Find Full Text PDFThe impact of internet connectivity when conducting a virtual clinical trial with participants living in rural areas.
Contemp Clin Trials Commun
December 2024
Kern Center for the Science of Health Care Delivery Research, Mayo Clinic, Rochester, MN, USA.
Aim: The purpose of this secondary analysis was to describe issues related to internet connections during a virtual randomized clinical trial (v-RCT) that included family caregiver participants living in rural areas.
Background: Success of v-RCTs depends on reliable, high-quality internet access, which can be problematic in rural areas.
Methods: Interventionists documented connectivity issues and corrections made to address connectivity in a narrative note after each virtual visit with family caregivers enrolled in a v-RCT.