The impact of gas transfer on responses to exercise training in patients with pulmonary hypertension.

Exercise training is recommended for pulmonary hypertension (PH). Post hoc analysis of the PH and Home-Based (PHAHB) trial stratified patients into two groups based on median diffusing capacity of the lungs for carbon monoxide (DLCO). Patients with higher DLCO had a greater improvement in physical activity performance in response to exercise training, compared to those with lower DLCO.

The psychological burden associated with metabolic syndrome: Evidence from UK and US older adults.

Introduction: We examined the psychological burden associated with metabolic syndrome (MetSyn).

Methods: We used comparable longitudinal data of older adults (≥50 years) from the UK (English Longitudinal Study of Aging) and the US (Health and Retirement Study). We defined MetSyn based on biomarker assessments (e.

Tracking the cellular uptake and phototoxicity of Ru(ii)-polypyridyl-1,8-naphthalimide Tröger's base conjugates.

Ruthenium(ii) complexes are attracting significant research attention as a promising class of photosensitizers (PSs) in photodynamic therapy (PDT). Having previously reported the synthesis of two novel Ru(ii)-polypyridyl-1,8-naphthalimide Tröger's base compounds 1 and 2 with interesting photophysical properties, where the emission from either the Ru(ii) polypyridyl centres or the naphthalimide moieties could be used to monitor binding to nucleic acids, we sought to use these compounds to investigate further and in more detail their biological profiling, which included unravelling their mechanism of cellular uptake, cellular trafficking and cellular responses to photoexcitation. Here we demonstrate that these compounds undergo rapid time dependent uptake in HeLa cells that involved energy dependent, caveolae and lipid raft-dependent mediated endocytosis, as demonstrated by confocal imaging, and transmission and scanning electron microscopy.

Transcriptional analysis in multiple barley varieties identifies signatures of waterlogging response.

Waterlogging leads to major crop losses globally, particularly for waterlogging-sensitive crops such as barley. Waterlogging reduces oxygen availability and results in additional stresses, leading to the activation of hypoxia and stress response pathways that promote plant survival. Although certain barley varieties have been shown to be more tolerant to waterlogging than others and some tolerance-related quantitative trait loci have been identified, the molecular mechanisms underlying this trait are mostly unknown.

Weathering the hunt: The role of barometric pressure in predator insects' foraging behaviour.

Abiotic factors strongly influence ecological interactions and the spatial distribution of organisms. Despite the essential role of barometric pressure, its influence on insect behaviour remains poorly understood, particularly in predators. The effect of barometric pressure variation can significantly impact biological control programs involving entomophagous insects, as they must efficiently allocate time and energy to search for prey in challenging environments.

Creating fairer futures for sustainability transitions.

Futures thinking is an expanding interdisciplinary field which is seen as a key element of transitioning towards a more sustainable planet and society. Developing fairer futuring is increasingly urgent in the context of the radical reconfiguration of current systems needed to meet complex global sustainability challenges. However, explicit consideration of uneven power and participation and the nature-society relations that feature in contemporary futuring processes has been given little explicit attention to date.

Dynamical-statistical seasonal forecasts of winter and summer precipitation for the Island of Ireland.

Seasonal precipitation forecasting is highly challenging for the northwest fringes of Europe due to complex dynamical drivers. Hybrid dynamical-statistical approaches offer potential to improve forecast skill. Here, hindcasts of mean sea level pressure (MSLP) from two dynamical systems (GloSea5 and SEAS5) are used to derive two distinct sets of indices for forecasting winter (DJF) and summer (JJA) precipitation over lead-times of 1-4 months.

Unemployment in women with psychosocial disabilities during the COVID-19 pandemic: Lessons from Tana River County, Kenya.

In low-income settings, the informal economy is a practical alternative to work and employment for persons with disabilities. However, the COVID-19 pandemic negatively affected the informal economy. This study aimed to explore the experiences of women with psychosocial disabilities in Kenya during the pandemic.

Fine-tuning the spike: role of the nature and topology of the glycan shield in the structure and dynamics of the SARS-CoV-2 S.

The dense glycan shield is an essential feature of the SARS-CoV-2 spike (S) architecture, key to immune evasion and to the activation of the prefusion conformation. Recent studies indicate that the occupancy and structures of the SARS-CoV-2 S glycans depend not only on the nature of the host cell, but also on the structural stability of the trimer; a point that raises important questions about the relative competence of different glycoforms. Moreover, the functional role of the glycan shield in the SARS-CoV-2 pathogenesis suggests that the evolution of the sites of glycosylation is potentially intertwined with the evolution of the protein sequence to affect optimal activity.

Reconstructed monthly river flows for Irish catchments 1766-2016.

A 250-year (1766-2016) archive of reconstructed river flows is presented for 51 catchments across Ireland. By leveraging meteorological data rescue efforts with gridded precipitation and temperature reconstructions, we develop monthly river flow reconstructions using the GR2M hydrological model and an Artificial Neural Network. Uncertainties in reconstructed flows associated with hydrological model structure and parameters are quantified.

Scaffold diversity for enhanced activity of glycosylated inhibitors of fungal adhesion.

is one of the most prevalent fungal pathogens involved in hospital acquired infections. It binds to glycans at the surface of epithelial cells and initiates infection. This process can be blocked by synthetic carbohydrates that mimic the structure of cell surface glycans.

Application of homogenization methods for Ireland's monthly precipitation records: Comparison of break detection results.

Time series homogenization for 299 of the available precipitation records for the island of Ireland (IENet) was performed. Four modern relative homogenization methods, that is, HOMER, ACMANT, CLIMATOL and AHOPS were applied to this network of station series where contiguous intact monthly records range from 30 to 70 years within the base period 1941-2010. Break detection results are compared between homogenization methods, and coincidences with available documentary information (metadata) were analysed.

A simple and efficient -mediated transient expression system to dissect molecular processes in and .

Unlabelled: The family Brassicaceae is a source of important crop species, including (oilseed rape), , and , that is used globally for oil production or as a food source ( pak choi or turnip). However, despite advances in recent years, including genome sequencing, a lack of established tools tailored to the study of crop species has impeded efforts to understand their molecular processes in greater detail. Here, we describe the use of a simple -mediated transient expression system adapted to and that could facilitate study of molecular and biochemical events in these species.

Multi-century trends to wetter winters and drier summers in the England and Wales precipitation series explained by observational and sampling bias in early records.

Globally, few precipitation records extend to the 18th century. The England Wales Precipitation (EWP) series is a notable exception with continuous monthly records from 1766. EWP has found widespread use across diverse fields of research including trend detection, evaluation of climate model simulations, as a proxy for mid-latitude atmospheric circulation, a predictor in long-term European gridded precipitation data sets, the assessment of drought and extremes, tree-ring reconstructions and as a benchmark for other regional series.

and species fine-scale spatial pattern affect diversity interactions in reconstructed tallgrass prairies.

Biodiversity and Ecosystem Function analyses aim to explain how individual species and their interactions affect ecosystem function. With this study, we asked in what ways do species interact, are these interactions affected by species planting pattern, and are initial (planted) proportions or previous year (realized) proportions a better reference point for characterizing grassland diversity effects?We addressed these questions with experimental communities compiled from a pool of 16 tallgrass prairie species. We planted all species in monocultures and mixtures that varied in their species richness, evenness, and spatial pattern.

The Relationship Between U.S. East Coast Sea Level and the Atlantic Meridional Overturning Circulation: A Review.

Scientific and societal interest in the relationship between the Atlantic Meridional Overturning Circulation (AMOC) and U.S. East Coast sea level has intensified over the past decade, largely due to (1) projected, and potentially ongoing, enhancement of sea level rise associated with AMOC weakening and (2) the potential for observations of U.

Using a Scenario-Neutral Framework to Avoid Potential Maladaptation to Future Flood Risk.

This study develops a coherent framework to detect those catchment types associated with a high risk of maladaptation to future flood risk. Using the "scenario-neutral" approach to impact assessment the sensitivity of Irish catchments to fluvial flooding is examined in the context of national climate change allowances. A predefined sensitivity domain is used to quantify flood responses to +2 °C mean annual temperature with incremental changes in the seasonality and mean of the annual precipitation cycle.

Transforming valences through transitive inference: How are faces emotionally dissonant?

Information that is emotionally incongruous with self-concepts can produce feelings of unease. This implies that embedding incongruous information in newly formed relational structures would have little effect on their previous emotive properties. Alternatively, Relational Frame Theory highlights the importance of contextualized stimulus-stimulus relations, where the structure of a relational series is key in determining the function of its elements.

Dual-task and electrophysiological markers of executive cognitive processing in older adult gait and fall-risk.

The role of cognition is becoming increasingly central to our understanding of the complexity of walking gait. In particular, higher-level executive functions are suggested to play a key role in gait and fall-risk, but the specific underlying neurocognitive processes remain unclear. Here, we report two experiments which investigated the cognitive and neural processes underlying older adult gait and falls.

Endogenous cross-talk of fungal metabolites.

Non-ribosomal peptide (NRP) synthesis in fungi requires a ready supply of proteogenic and non-proteogenic amino acids which are subsequently incorporated into the nascent NRP via a thiotemplate mechanism catalyzed by NRP synthetases. Substrate amino acids can be modified prior to or during incorporation into the NRP, or following incorporation into an early stage amino acid-containing biosynthetic intermediate. These post-incorporation modifications involve a range of additional enzymatic activities including but not exclusively, monooxygenases, methyltransferases, epimerases, oxidoreductases, and glutathione S-transferases which are essential to effect biosynthesis of the final NRP.