863 results match your criteria: "Max Super Speciality Hospital[Affiliation]"

Objective: To evaluate the incidence of sentinel lymph node (SLN) metastasis observed in patients with presumed low- and intermediate-risk endometrial cancer (EC) and change in stage and adjuvant therapy resulting from SLN analysis. Secondary objectives include assessing the rates of detection of SLN using indocyanine green (ICG) dye and complication rates.

Methods: Between March 2017 and December 2023, 210 patients were included in the study.

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Article Synopsis
  • * These systems provide benefits such as improved functional outcomes, reduced revision rates, and quicker recovery, especially in complex surgeries, while offering surgeons consistent results in challenging anatomies.
  • * The MISSO Robotic System is positioned as a cost-effective solution for South Asian patients, addressing region-specific anatomical challenges and increasing accessibility in high-demand healthcare settings, which ultimately aims to redefine orthopedic surgical standards.
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Total Hip Replacement in a Patient with Erdheim-Chester's Disease: A Case Report.

JBJS Case Connect

October 2024

Max Institute of Musculoskeletal Sciences, Max Super Speciality Hospital, Saket, New Delhi, India.

Case: Erdheim-Chester's disease (ECD) is a rare multisystem disorder considered as a neoplasm of non-Langerhans cell histiocytes. We report a case of uncemented total hip arthroplasty in a 74-year-old patient with ECD for femoral neck fracture with pathological involvement of distal metaphysis and diaphysis. We reviewed the literature on bony involvement.

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Fundic gland adenocarcinoma.

BMJ Case Rep

December 2024

Department of Gastroenterology, Hepatology and Endoscopy, Max Super Speciality Hospital Saket, New Delhi, Delhi, India.

Gastric malignancy is one of the most common malignancies diagnosed worldwide. Over the past many decades, extensive research has been made into the risk factors, pathogenesis and prognosis of gastric adenocarcinoma. However, gastric adenocarcinoma of the fundic gland (GA-FG) has been recently defined, and not much is known about its risk factors and pathogenesis.

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 Treatment of ruptured broad-necked intracranial aneurysms by endovascular therapy is technically burdensome. It is commonly treated with stent- and balloon-assisted coils embolization. The aim of this study was to evaluate clinical and radiological outcomes following double micro-catheter (MC) technique.

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Anesthetic challenges in pediatric robot-assisted surgeries.

Saudi J Anaesth

October 2024

Department of Anaesthesia and Pain Management, Max Super Speciality Hospital, Saket, New Delhi, India.

With the advent of minimally invasive surgeries, robot-assisted techniques have gained popularity because they overcome various shortcomings of standard laparoscopic surgeries. Despite the associated costs and limitations among the pediatric population, surgeon comfort due to the ergonomic design, in combination with enhanced three-dimensional high-fidelity imaging and tissue handling, may offer better surgical and postoperative outcomes. However, robotic surgeries require innovations with regard to patient positioning and the overall arrangement of operative equipment and personnel.

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Background/aims: Per-oral (PO) administration of tacrolimus (TAC) results in inadequate trough levels in the early postoperative period in liver-transplant (LT) recipients who undergo Roux-en-Y hepaticojejunostomy for biliary reconstruction. Sublingual administration (SL) of tacrolimus provides an alternative route in such patients.The objectives of this study were to assess the feasibility and safety of SL tacrolimus in adult LT-recipients in the early postoperative period and to compare therapeutic efficacy of SL administration of tacrolimus versus PO route.

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Background: Sepsis is a global health problem with high morbidity and mortality. Low- and middle-income countries have a higher incidence and poorer outcome with sepsis. Large epidemiological studies in sepsis using Sepsis-3 criteria, addressing the process of care and deriving predictors of mortality are scarce in India.

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We describe a patient who underwent plug-assisted retrograde transvenous obliteration for gastric varices. After the procedure, the patient developed hypotension and tachycardia. Contrast-enhanced computed tomography showed a left adrenal hematoma.

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C3 glomerulopathy: a kidney disease mediated by alternative pathway deregulation.

Front Nephrol

October 2024

Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany.

C3 glomerulopathy (C3G) is an ultra-rare complement-mediated kidney disease caused by to the deregulation of the alternative pathway (AP) of proximal complement. Consequently, all effector loops of the complement are active and can lead to pathologies, such as C3a- and C5a-mediated inflammation, C3b opsonization, surface C3b-mediated AP C3 convertase assembly, C3 cleavage product deposition in the glomerulus, and lytic C5b-9/MAC cell damage. The most common pathologic mechanisms are defective chronic alternative pathway deregulation, mostly occurring in the plasma, often causing C3 consumption, and chronic complement-mediated glomerular damage.

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A Study on Radiation Level at the Treatment Plane Due to Induced Activity in Linear Accelerator Head.

J Med Phys

September 2024

Department of Nuclear Radiation Measurements and Applications, Defence Laboratory, DRDO, Jodhpur, Rajasthan, India.

Background: The induced activity is produced in the target, monitor chamber, flattening filter (FF), collimating jaws, etc., when a high-energy photon beam is utilized for radiation therapy. This may result in add-on exposure to radiation professionals.

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Breaking boundaries: Ticagrelor monotherapy in high-risk patients.

Int J Cardiol Heart Vasc

December 2024

Medical Affairs, AstraZeneca Pharma India Ltd, India.

Atherosclerotic plaque formation is a leading cause of arterial thrombosis that significantly impacts global health by instigating major adverse cardiovascular events (MACE) like myocardial infarction (MI) and stroke. Platelets are central to this process, leading to the development of antiplatelet therapies, to mitigate MACE risks. The combination of aspirin with a potent P2Y inhibitor known as dual antiplatelet therapy (DAPT) is the standard for post-percutaneous coronary intervention (PCI) aimed at reducing ischemic events.

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Paraneoplastic Proliferative Myositis on 18 F-FDG PET/CT.

Clin Nucl Med

January 2025

From the Department of Nuclear Medicine, Max Super Speciality Hospital, Saket, New Delhi, India.

We present a rare and never-before-reported case of paraneoplastic proliferative myositis that was incidentally detected in a 42-year-old man who had been receiving systemic cytotoxic chemotherapy for classic Hodgkin lymphoma. We highlight his 18 F-FDG PET/CT findings and its utility in helping to diagnose this condition, avoiding unnecessary surgical resection and the added costs associated with it.

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Background Rabbit antithymocyte globulin (rATG) is frequently utilized as an induction therapy in kidney transplant recipients (KTRs). Full-dose rATG induction therapy (7-10 mg/kg) has been associated with increased morbidity. However, definitive data on the appropriate rATG dosage remains scarce.

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Therapeutic Plasma Exchange in Hepatology: Indications, Techniques, and Practical Application.

J Clin Exp Hepatol

September 2024

Hepatology and Liver Transplant, Centre for Liver & Biliary Sciences, Max Super Speciality Hospital, Saket, New Delhi, 110017, India.

It is sobering that many liver failure patients die in the absence of liver transplantation (LT), and reducing its morbidity and mortality urgently needs more non-transplant treatment options. Among the several artificial liver support devices available, therapeutic plasma exchange (TPE) is the only one that improves survival in acute liver failure (ALF) patients. In many other disorders, data on survival benefits and successful bridging to transplant is encouraging.

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Background: Dengue is the most re-emergent infection, with approximately 100 million new cases reported annually, yet no effective treatment or vaccine exists. Here, we aim to define the microbial community structure and their functional profiles in the dengue positive patients with varying disease severity.

Methodology/principal Findings: Hospital admitted 112 dengue-positive patients blood samples were analyzed by dual RNA-sequencing to simultaneously identify the transcriptionally active microbes (TAMs), their expressed genes and associated pathways.

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Article Synopsis
  • - Antimicrobial resistance (AMR) in bacterial species complicates the treatment of lower respiratory tract infections (LRTIs), increasing hospitalization and mortality rates among affected patients.
  • - A study analyzed bronchoalveolar lavage fluid from 84 LRTI patients using advanced sequencing methods, finding that a new technology (mNGS) was more effective in detecting pathogens compared to conventional methods, revealing a variety of respiratory and non-respiratory pathogens, as well as significant resistance genes.
  • - The findings emphasize the importance of mNGS in accurately identifying pathogens and AMR, which is critical for better understanding and addressing LRTIs and combating rising antibiotic resistance.
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The Sepsis Score Dilemma: Balancing Precision and Utility.

Indian J Crit Care Med

October 2024

Department of Anaesthesiology & Critical Care, Lady Hardinge Medical College, New Delhi, India.

Pande R, Pandey M. The Sepsis Score Dilemma: Balancing Precision and Utility. Indian J Crit Care Med 2024;28(10):906-907.

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TCR repertoire dynamics and their responses underscores dengue severity.

iScience

October 2024

Division of Immunology and Infectious Disease Biology, INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) laboratory, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Mall Road, Delhi 110007, India.

Article Synopsis
  • This study explores the variations in T cell receptor (TCR) responses in dengue patients, particularly focusing on those with severe infections.
  • Analysis of RNA-seq data from 112 patients revealed that severe cases had notable clinical signs such as low white blood cells and specific TCR chain diversity, suggesting unique immune responses.
  • The research also found that genetic mutations in the dengue virus corresponded with changes in specific TCR chains, emphasizing the importance of TCR dynamics in understanding dengue disease progression and potential future infections.
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