802 results match your criteria: "Mauriziano Hospital[Affiliation]"

Article Synopsis
  • The IMDC score is crucial for predicting outcomes and guiding treatment in patients with metastatic renal cell carcinoma (mRCC), especially when starting therapy with nivolumab.
  • A multicenter study analyzed 492 mRCC patients to see how changes in IMDC categories affected their overall survival (OS) and progression-free survival (PFS) after starting nivolumab.
  • Results indicated that patients maintaining or improving their IMDC category had better survival outcomes compared to those whose condition worsened, highlighting the importance of IMDC monitoring in mRCC treatment.
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Despite a biologically established causative role of viral hepatitis (VH), i.e. HBV and HCV infections, on intrahepatic cholangiocarcinoma (ICC), only few large Western cohorts exploring the association between VH and ICC development are available.

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: Nowadays, thanks to the introduction of the VI-RADS scoring system, mpMRI has shown promising results in pre-TURBT assessment of muscular invasiveness of BCa, even if its application in everyday practice is still limited. This might be due to a lack in the literature about the learning curve of radiologists and about the characteristics of the exam. With the aim to reduce scan time and patient discomfort while maintaining diagnostic accuracy, bpMRI has been introduced as a possible alternative to mpMRI in this group of patients.

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Pancreatic cancer and long survivors: a survey of Italian society of oncological surgery (SICO).

Updates Surg

November 2024

Division of Pancreatic Surgery, Department of Internal Medicine and Surgery (DIMEC), IRCCS, Azienda Ospedaliero Universitaria Di Bologna, Alma Mater Studiorum, University of Bologna, S. Orsola-Malpighi Hospital, Via Massarenti n.9, 40138, Bologna, Italy.

Long-term survivors after pancreatic resection for PDAC are rare, constituting a specific subset of patients that remains poorly understood. The aim of this survey is to describe the current landscape related to survival in the Italian context and identify factors associated with long-term survival. An online survey, conducted by the Italian Society of Oncological Surgery (SICO) and endorsed by Italian Association of the Study of the Pancreas (AISP) and Italian Association of Hepatobiliary Pancreatic Surgery (AICEP), was distributed to surgeons in July 2023.

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Lung function trajectories in common variable immunodeficiencies: An observational retrospective multicenter study.

J Allergy Clin Immunol

November 2024

Department of Medicine, DIMED, University of Padova, Padova, Italy; Internal Medicine 1, Ca' Foncello University Hospital, AULSS2, Treviso, Italy.

Background: Respiratory disease is a frequent cause of morbidity and mortality in common variable immunodeficiencies (CVIDs); however, lung function trajectories are poorly understood.

Objective: We sought to determine lung physiology measurements in CVIDs, their temporal trajectory, and their association with clinical and immunologic parameters.

Methods: This retrospective study from 5 Italian centers included patients with CVIDs who had longitudinal pulmonary function tests (PFTs) and chest computed tomography scan available.

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Introduction: Proximal humerus fractures are usually treated with rigid angle-stable plates or nails. As an alternative, semi-rigid, minimally invasive systems have been developed for supportive fixation. A new system uses this principle with 2.

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Long-term outcomes of PARP inhibitors in ovarian cancer: survival, adverse events, and post-progression insights.

ESMO Open

November 2024

Department of Oncology, Immuno-Oncology Service, University Hospital of Lausanne (CHUV-UNIL), Lausanne, Switzerland; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland; Agora Cancer Research Center, Lausanne, Switzerland. Electronic address:

Poly-ADP-ribose polymerase inhibitors (PARPis) have revolutionized the management of BRCA-mutated (BRCA) and homologous recombination deficiency (HRD)-positive ovarian cancer (OC). While long-term analyses clearly support the use of PARPi as maintenance therapy after first-line chemotherapy, recent data have raised concerns on detrimental overall survival (OS) in non-BRCA OC, a greater incidence of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), and unfavorable outcomes following subsequent platinum-based chemotherapy in pretreated OC patients. In this report we discuss the long-term follow-up results from phase III trials in pretreated OC patients, which led to the Food and Drug Administration's withdrawal of PARPi indications in this setting.

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Limited evidence exists concerning the prognostic impact of baseline left ventricular ejection fraction (LVEF) on outcomes among women undergoing transcatheter aortic valve implantation (TAVI), which we aimed to investigate in the present analysis. Patients from the Women's International Transcatheter Aortic Valve Implantation (WIN-TAVI) registry were categorized according to baseline LVEF into 3 groups: reduced (LVEF ≤40%), mildly reduced (LVEF between 41% and 49%), and preserved (LVEF ≥50%) LVEF. The primary (Valve Academic Research Consortium 2 [VARC-2]) efficacy point was defined as a composite of mortality, stroke, myocardial infarction, hospitalization for valve-related symptoms or heart failure, or valve-related dysfunction at 1 year.

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The management of advanced endometrial cancer (EC) has changed in the last few years due to the introduction of a new molecular classification and the approval of immunotherapy. For a long time, carboplatin plus paclitaxel was considered the standard treatment for first-line advanced EC, since the approval of the combination of chemotherapy plus immunotherapy. For patients with recurrent EC, with previous platinum-based chemotherapy, single-agent immunotherapy or in combination with tyrosine-kinase inhibitor (TKI) has been approved according to mismatch repair status.

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Impact of metabolism-related markers on outcomes in ovarian cancer patients: Findings of the MITO16A/MaNGO-OV2 trial.

Int J Biol Markers

December 2024

Uro-Gynecological Medical Oncology, Istituto Nazionale Tumori, IRCCS-Fondazione G. Pascale, Napoli, Italy.

Article Synopsis
  • In ovarian cancer, a comprehensive study examined various metabolism-related markers to understand their prognostic value, but results showed mixed outcomes in large patient groups.
  • The study used advanced techniques on tissue samples from over 300 patients to analyze markers tied to glycolysis, glutamine metabolism, and hypoxia, but found that only one marker (GLS) hinted at a connection to patient survival, which was not statistically significant after adjustments.
  • Ultimately, the research highlights the diversity of metabolism markers in ovarian cancer and suggests their expression patterns may still be relevant for future drug development, even if they don't currently correlate with treatment outcomes.
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Systemic hormone therapy after breast and gynecological cancers: an Italian expert group consensus opinion.

Climacteric

November 2024

Coordinator of the Italian Group of Special Interest on Menopause of the Italian Society of Obstetrics and Gynecology, Women's Wellness Foundation, Cagliari, Italy.

Article Synopsis
  • * ET/HT can be cautiously used after vulvar cancers, melanoma, and certain endometrial cancers, while more caution is needed with adenocarcinomas and uterine sarcomas.
  • * For breast cancer survivors, ET/HT is likely safe after ER/PR-negative cancers but should be applied carefully after ER/PR-positive cases.
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Article Synopsis
  • The study aimed to assess the rise in new cases of Medication-Related Osteonecrosis of the Jaw (MRONJ) among patients with osteoporosis and other non-cancerous bone diseases in Northwestern Italy from 2007 to 2022.
  • Researchers analyzed 198 MRONJ cases, finding that the majority were linked to osteoporosis and primarily involved treatments with bisphosphonates.
  • The findings revealed a significant increase in new MRONJ cases over the years, with a call for better collaboration among healthcare specialists for early detection and improved patient outcomes.
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Detection of Mutations in Systemic Mastocytosis: How, When, and Why.

Int J Mol Sci

October 2024

Department of Clinical and Biological Sciences, University of Turin, Mauriziano Hospital, 10128 Turin, Italy.

Article Synopsis
  • * The most common mutation is p.D816V, but there are other less frequent mutations that are typically undetectable with standard testing methods.
  • * New, more sensitive detection methods are being developed, and the review discusses how to approach these tests for diagnosing and monitoring mastocytosis patients.
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Withdrawal notice to .

Lancet Reg Health Eur

September 2024

National Cancer Institute, IRCCS Fondazione G.Pascale, Naples, Italy.

Article Synopsis
  • The article with DOI: 10.1016/j.lanepe.2024.100973 is officially retracted.
  • The retraction indicates that the content is no longer valid or reliable.
  • For readers, this means they should disregard any information or conclusions presented in that article.
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Article Synopsis
  • A study evaluated the effectiveness of a commercial sponge diffuser versus a custom-made cannula and no CO2 in preventing neurological events after aortic valve replacement surgery.
  • Three patient groups were compared based on their CO2 delivery method, with a focus on outcomes like stroke, dizziness, and mechanical ventilation duration.
  • Results showed that the sponge diffuser group had a significantly lower duration of mechanical ventilation, decreased 30-day mortality, and fewer neurological events compared to the other methods.
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Article Synopsis
  • * They are less likely to receive crucial procedures and effective medications, so assessing factors like frailty and other health conditions is vital for tailoring their care.
  • * There is a lack of research on elderly individuals with ACS, making it critical for clinicians to develop targeted strategies to improve these patients' treatment and quality of life as the population ages.
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How a Novel Approach of Allergy Call Center Improved the Management of the Anti-COVID Vaccination Campaign in Piedmont: Italy.

J Epidemiol Glob Health

December 2024

Department of Medical Sciences, Immunology and Allergy Unit, University of Turin, Mauriziano Hospital, 10128, Turin, Italy.

Article Synopsis
  • A study in Piedmont, Italy evaluated the impact of an Allergy Call Center (ACC) program established to support patients at high risk for allergic reactions during the COVID-19 vaccination campaign.
  • The ACC operated from May 2021 to December 2022, receiving 15,865 calls, with only 336 patients needing further referral to the specialized unit, indicating effective management of consultations.
  • Overall, the study highlighted the success of proactive screening in reducing allergy-related concerns linked to COVID-19 vaccination, streamlining the referral process for high-risk patients.
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Article Synopsis
  • - Patient-reported outcome measures (PROMs) are tools that help assess a patient's health at a specific time and are important for personalized healthcare.
  • - The paper reviews the use of visual analog scales (VAS) for measuring asthma and allergic rhinitis control, particularly focusing on the MASK-air app, which includes electronic VAS forms.
  • - A randomized controlled trial was conducted to validate the electronic VAS, and further evaluations confirmed the effectiveness of VAS questions and additional medication scores for allergic asthma symptoms.
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Article Synopsis
  • The study evaluated the use of frontline TKI therapy in elderly patients (75 years or older) with chronic phase chronic myeloid leukemia (CP-CML) among a large cohort of 332 patients.
  • Results showed that 85.8% of patients received imatinib (IM), while 14.2% were treated with second-generation TKIs (2G-TKI) like dasatinib and nilotinib, with a notable percentage starting on reduced doses.
  • The findings indicated increased usage of IM after generic versions became available in Italy, but significant discontinuation rates due to resistance and toxicities were observed, highlighting the need for personalized treatment assessments and further studies on lower TKI doses.
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Intranasal Versus Oral Treatments for Allergic Rhinitis: A Systematic Review With Meta-Analysis.

J Allergy Clin Immunol Pract

December 2024

MEDCIDS, Department of Community Medicine, Information, and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal; CINTESIS@RISE, Health Research Network, MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal.

Background: Treatments for allergic rhinitis include intranasal or oral medications.

Objective: To perform a systematic review with meta-analysis comparing the effectiveness of intranasal corticosteroids or antihistamines versus oral antihistamines or leukotriene receptor antagonists in improving allergic rhinitis symptoms and quality of life.

Methods: We searched four bibliographic databases and three clinical trial datasets for randomized controlled trials (1) assessing patients aged 12 years and older with seasonal or perennial allergic rhinitis, and (2) comparing intranasal corticosteroids or antihistamines versus oral antihistamines or leukotriene receptor antagonists.

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Article Synopsis
  • A study was conducted to compare robotic minor liver resections (RMLR) with laparoscopic minor liver resections (LMLR) in patients undergoing surgery on the anterolateral liver segments.
  • The analysis included over 10,000 patients and employed propensity score matching to balance the groups for accuracy in comparisons.
  • Results indicated RMLR had benefits like less blood loss, lower major morbidity, and shorter hospital stays than LMLR, although the difference in 30-day readmission rates suggested RMLR may have some drawbacks.
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