Revisiting the Multifaceted Therapeutic Potential of Withaferin A (WA), a Novel Steroidal Lactone, W-ferinAmax Ashwagandha, from (L) Dunal.

Dunal, abundant in the Indian subcontinent as Ashwagandha or winter cherry, is a herb of unprecedented therapeutic value. The number of ailments for which crude Ashwagandha extract can be used as a preventive or curative is practically limitless; and this explains why its use has been in vogue in ancient Ayurveda since at-least about four thousand years. The therapeutic potential of Ashwagandha mainly owes from its reservoir of alkaloids (isopelletierine, anaferine), steroidal lactones (withanolides) and saponins with an extra acyl group (sitoindoside VII and VIII).

Therapeutic potential of lipid nanosystems for the treatment of Parkinson's disease.

Parkinson's disease (PD) is the second most common neurodegenerative disorder. The degeneration of dopaminergic neurons in the midbrain is primarily responsible for the onset of the disease. The major challenge faced in the treatment of PD is the blood-brain barrier (BBB), which impedes the delivery of therapeutics to targeted locations.

Evaluation of total glutathione-s-transferase levels in serum of patients with oral malignancy.

Introduction: Squamous cell carcinoma-related antigen is not always sensitive enough for the early detection of oral cancer which is why a new marker has been desired as a substitute to be applied for serum diagnosis of oral cancer. Reactive oxygen species (ROS) has been known to play an important role in carcinogenesis. Glutathione-s-transferases (GSTs) are a family of eukaryotic and prokaryotic phase-II metabolic isoenzymes involved in xenobiotic detoxification.

Two new species of Pseudosmittia Edwards, 1932 from India with a key to Oriental species adult males (Diptera: Chironomidae: Orthocladiinae).

In this study, we described and illustrated two new species, Pseudosmittia luna and Pseudosmittia valida based on the adult males from the plains of West Bengal, India. A DNA barcode of Pseudosmittia luna sp. n.

GC/MS and LC/MS Phytochemical Analysis of Vigna unguiculata L. Walp Pod.

Vigna unguiculata (L. Walp) or Cowpea pod methanolic extracts phytochemical analysis, total phenolic content (TPC), and secondary metabolite profiling were determined using gas chromatography-mass spectrometry (GC/MS) and liquid chromatography-mass spectrometry (LC/MS) analysis. GC/MS analysis revealed twenty compounds in the extract, while LC/MS analysis identified twenty-four compounds.

A Scoping Review of Changes to Patient-Doctor Communication During COVID-19.

Effective communication between patients and doctors is fundamental to high-quality healthcare, patient safety, and overall satisfaction. However, the onset of COVID-19 has prompted significant shifts in communication from in-room and face-to-face interactions to virtual consults. The impact of this pandemic-related change on patient-doctor communication goals, processes, attributes, and environment remains unclear.

Beneficial Effects of a Novel Fenugreek Seed Extract (, Furocyst®) in Women with Polycystic Ovary Syndrome (PCOS): A Follow-up Compliance Clinical Investigation.

Introduction: Polycystic Ovary Syndrome (PCOS) is an endocrine disorder which accounts for infertility around the world. The disease is characterized by elevated secretion of androgens in the women which results in enlargement of ovaries with accumulation of fluid filled cysts, irregular menstrual cycles, and hirsutism. This study reports the efficacy of a patented, standardized Trigonella foenum-graecum extract (Furocyst®) as an effective phytotherapeutic for effective management of PCOS.

An integrative GC-MS and LC-MS metabolomics platform determination of the metabolite profile of L. root, and in silico & in vitro evaluation of its antibacterial & antidiabetic activities.

The L. tree is a member of the family and the genus Bombax. Both Chinese and Indian traditional medicine have made extensive use of it in the treatment of sickness.

Advances in modified antimicrobial peptides as marine antifouling material.

Biofouling is the undesirable attachment of organisms and their by-products on surfaces. It has become a severe problem in the industries that utilize devices and facilities in the marine environment. Several antifouling strategies have been developed, but many have adverse effects on numerous species, the surrounding environment, and marine devices.

Efficacy of a Proprietary Fenugreek Seed Extract (, Furocyst®) in Women with Polycystic Ovary Syndrome (PCOS): a Randomized, Double-Blind, Placebo-Controlled Study.

Introduction: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenemia, a quite common heterogenous endocrine/hormonal disorder, and accompanied by elevated androgen level, menstrual irregularity, and hirsutism. The consequences include infertility or miscarriage. It is a challenging problem to the physicians.

The emergence of metal oxide nanoparticles (NPs) as a phytomedicine: A two-facet role in plant growth, nano-toxicity and anti-phyto-microbial activity.

Anti-microbial resistance (AMR) has recently emerged as an area of high interest owing to the rapid surge of AMR phenotypes. Metal oxide NPs (MeONPs) have been identified as novel phytomedicine and have recently peaked a lot of interest due to their potential applications in combating phytopathogens, besides enhancing plant growth and yields. Numerous MeONPs (TiO, MgO, CuO, AgO, SiO, ZnO, and CaO) have been synthesized and tested to validate their antimicrobial roles without causing toxicity to the cells.

Characterization and adsorption of malachite green dye from aqueous solution onto L. (Willow tree) leaves powder and its respective biochar.

In the present study, the use of low-cost, highly efficient, eco-friendly, and abundantly available (in Kashmir region, J&K India) willow leaves from which adsorbents like willow leaves powder (WLP) and willow leaves biochar (WLB) were prepared, have been found to be efficient for malachite green (MG) dye removal and can be used as an alternative to the current expensive methods of removing the same dye from an aqueous solution. The techniques like Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), and carbon, hydrogen, nitrogen, sulphur (CHNS) analyser were used to characterize the samples without any chemical treatment. SEM of the adsorbents shows the presence of different sized pores, cracks, and crevices.

Exosomal long noncoding RNAs - the lead thespian behind the regulation, cause and cure of autophagy-related diseases.

Recent advances in exosome biology have revealed significant roles of exosome and their contents in intercellular communication. Among various exosomal content, long non-coding RNAs (lncRNAs), which have a large size (˃ 200 nt) and lack protein coding potential, are known to play key roles in intercellular communication and novel biomarkers of various metabolic disorders. Moreover, long non-coding RNAs are often involved in the regulation of various cellular processes such as autophagy, apoptosis, cell proliferation.

Fluorometric trace methanol detection in ethanol and isopropanol in a water medium for application in alcoholic beverages and hand sanitizers.

Detection of methanol (MeOH) in an ethanol (EtOH)/isopropanol ( PrOH) medium containing water is crucial to recognize MeOH poisoning in alcoholic beverages and hand sanitizers. Although chemical sensing methods are very sensitive and easy to perform, the chemical similarities between the alcohols make MeOH detection very challenging particularly in the presence of water. Herein, the fluorometric detection of a trace amount of MeOH in EtOH/ PrOH in the presence of water using alcohol coordinated Al(iii)-complexes of an aldehydic phenol ligand containing a dangling pyrazole unit is described.

Critical review on karyotype diversity in lentil based on classical and molecular cytogenetics.

Lentil is an annual protein rich valuable edible crop with only one cultivated and six wild taxa. Keeping in mind its narrow gene pool, the genus deserves critical assessment of genomic diversity at the chromosomal level. Genetic diversity represents the heritable variation within and between populations of organisms.

MiR-624-5p enhances NLRP3 augmented gemcitabine resistance via EMT/IL-1β/Wnt/β-catenin signaling pathway in ovarian cancer.

The current study investigates the NLRP3's cytotoxicity inhibitory effect among ovarian cancer cells and how it interacts with Wnt/β-catenin in vitro conditions. Further, the study also analyzed the regulatory role of NLRP3 in resistance to gemcitabine among ovarian cancer cells and its underlying interaction mechanisms with Wnt/β-catenin in vitro. The current in vitro study detailed that when downregulating NLRP3, it could enhance the gemcitabine sensitivity in GRC cells.

DNA damage induced cellular senescence and it's PTEN-armed exosomes-the warriors against prostate carcinoma cells.

Exosomes are one type of small extracellular vesicles (EVs) having a size range of 30-150 nm and secreted by the endosomal compartment of most eukaryotic cells. It has been found that exosomes (EVs) can serve as a communicating vehicle to transfer information among cells and thus can be associated with numerous physiological and pathological functions. In this study, we have isolated exosomes (EVs) from two different human cancer cell lines.

Karyotype diversity in cultivated and wild Indian rice through EMA-based chromosome analysis.

India is known for its diverse cultivated and wild rice germplasm. In today's crop improvement programmes, wild relatives are much-needed genetic repository of valuable traits. Analysis of genetic diversity at the chromosomal level is one cost-effective tool to unlock foundational information related to genetics and plant breeding.

Protective effect of indomethacin on vanadium-induced adrenocortical and testicular damages in rat.

Vanadium toxicity is a globally recognized threat to the reproductive health of man and animal. However the mechanism of vanadium-induced damage to the testicular and adrenocortical tissues is not fully characterized. It was hypothesized that prostaglandins may partially mediate the inflammatory response to vanadate damage.

Conservation of floral, fruit and chromosomal diversity: a review on diploid and polyploid Capsicum annuum complex in India.

Capsicum as a spice crop, has wild and cultivated forms admired globally, including Indian subcontinent with vast climatic ranges. Systematic representation of the Indian Capsicum is required to address species relationships and sustainable agriculture, in face of unpredictable climatic conditions. We have updated the catalogue of Indian 'C.

Utilization of Guanidine-Based Ancillary Ligands in Arene-Ruthenium Complexes for Selective Cytotoxicity.

A family of three water-soluble half-sandwich arene-ruthenium complexes, depicted as - , having the general formula [Ru(-cymene)(L)Cl]Cl has been synthesized, where L represents (1-benzo[]imidazol-2-yl)guanidine ( ) or (benzo[]oxazol-2-yl)guanidine ( ) or (benzo[]thiazol-2-yl)guanidine ( ). The crystal structure of complex has been determined. The complexes show several absorption bands in the visible and ultraviolet regions, and they also show prominent emission in the visible region while excited near 400 nm.

Mathematical modeling for the outbreak of the coronavirus (COVID-19) under fractional nonlocal operator.

A mathematical model for the spread of the COVID-19 disease based on a fractional Atangana-Baleanu operator is studied. Some fixed point theorems and generalized Gronwall inequality through the AB fractional integral are applied to obtain the existence and stability results. The fractional Adams-Bashforth is used to discuss the corresponding numerical results.

Withdrawal Notice: Ionic Liquid Mediated Synthesis of Schiff bases Bearing Thiazole and Indole Moieties.

Unlabelled: The article has been withdrawn at the request of the authors and editor of the journal Current Organic Synthesis. Bentham Science apologizes to the readers of the journal for any inconvenience this may cause. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.