Targeted isolation of lignans and triterpenoids from kadsura coccinea by molecular networking and anti-RA-FLS activity.

In this study, six compounds (four triterpenoids named heilaohutriterpenes A-D and two lignans name heilaohusuins F and G) together with 21 known compounds were isolated from roots of Kadsura coccinea (Lem.) A. C.

Causal relationships between immune cells, inflammatory cytokines, and pertussis: Bidirectional 2-sample Mendelian randomization study and mediation analysis.

Studies have shown that immune cells play an important role in the occurrence and development of pertussis, but the specific causal relationships are yet to be determined. Additionally, inflammatory cytokines, as regulators of immune responses, may mediate the relationship between immune cells and pertussis, and the specific mechanisms involved require further exploration. This study utilizes data from multiple large-scale genome-wide association studies, covering 731 types of immune cells and 91 types of inflammatory cytokines.

Rotenone adaptation promotes migration and invasion of p53-wild-type colon cancer through lipid metabolism.

Background: The association between mitochondrial dysfunction and multiple metabolic adaptations is increasingly being proven. We previously elucidated that mitochondrial complex I deficiency can promote glycolysis in mut-p53 SW480 cells. However, studies have revealed a phenotype with attenuated glycolysis but enhanced fatty acid oxidation (FAO) in invasive tumors.

Related factors of bloodstream infections associated with urinary tract infections and pathogenetic characteristics analysis.

Objectives: To explore correlations between biomarker indices and urosepsis severity, and investigate the prevalence of drug-resistant Escherichia coli in a patient population at the General Hospital of Ningxia Medical University in the Ningxia region of China.

Methods: Patients with urinary tract infection-associated sepsis were categorized into three groups: a septic non-shock group (NSSPU), a septic shock group (USG), and a control group with non-sepsis cases of simple urinary tract infections (CG). The study analyzed various biomarkers, including the percentage of neutrophils (N%), neutrophil-to-lymphocyte ratio (NLR), and lactate (La), to assess their predictive value for urogenital sepsis severity.

Integrated analysis of single-cell and bulk transcriptome reveals hypoxia-induced immunosuppressive microenvironment to predict immunotherapy response in high-grade serous ovarian cancer.

Background: Hypoxia is significantly associated with cancer progression and treatment outcomes. Nevertheless, the precise molecular mechanisms underlying the hypoxia-induced immunosuppressive microenvironment in high-grade serous ovarian cancer (HGSOC) are still not fully understood.

Methods: By analyzing five independent transcriptomic datasets, we investigated the effect of hypoxia on prognosis and tumor microenvironment (TME) in HGSOC.

Pan-cancer landscape of disulfidptosis across human tumors.

Objective: Disulfidptosis is a newly discovered disulfide stress-induced cell death form. Clinical significance and biological mechanisms of disulfidptosis in human cancers need to be further elucidated. Thus, this study was designed to characterize pan-cancer landscape of disulfidptosis across human tumors.

Impact of Body Mass Index on Outcomes of Cervical Cerclage: A Systematic Review and Meta-Analysis.

Introduction: The purpose of the review was to examine the impact of maternal body mass index (BMI) on outcomes of cervical cerclage for cervical insufficiency.

Methods: This prospectively registered review (CRD42024512436) searched PubMed, Embase, Scopus, and Web of Science for comparative studies published before 6 March 2024. Maternal and neonatal outcomes of females undergoing cerclage were compared based on BMI.

The effect of lumbar multifidus muscle degeneration on upper lumbar disc herniation.

Purpose: This study aimed to investigate the effect of lumbar multifidus muscle (MF) degeneration on upper lumbar disc herniation (ULDH).

Methods: This study used 3.0T magnetic resonance imaging (MRI) T2 axial weighted images to retrospectively analyze 93 ULDH patients and 111 healthy participants.

[Risk factors for the occurrence of bronchiolitis obliterans in children with refractory pneumonia and the predictive value of the factors].

Objectives: To investigate the risk factors for the occurrence of bronchiolitis obliterans (BO) in children with refractory pneumonia (RMPP) and their predictive value of the factors.

Methods: A retrospective analysis was performed for the medical records of 156 children with RMPP who were admitted to the hospital from May 2020 to March 2024. According to the diagnostic criteria for BO, they were divided into a BO group (=76) and a non-BO group (=80).

Development and validation of nomogram models for severe and fatal COVID-19.

Background: The coronavirus disease 2019 (COVID-19) has exhibited escalating contagion and resistance to immunity, resulting in a surge in infections and severe cases. This study endeavors to formulate two nomogram predictive models aimed at discerning patients at heightened risk of severe and fatal outcomes upon hospital admission. The primary objective is to enhance clinical management protocols and mitigate the incidence of severe illness and mortality associated with COVID-19.

Acupuncture as an Adjunct to Lifestyle Interventions for Weight Loss in Simple Obesity: A Systematic Review and Meta-Analysis.

Objective: This study aims to evaluate the efficacy of acupuncture as an adjunct to lifestyle interventions on weight loss in simple obesity.

Methods: Potentially eligible studies that assessed anthropometric outcomes as well as glucose and lipid metabolism following acupuncture combined with lifestyle interventions in simple obesity patients were searched from eight databases from inception to October 2023. All analyses were performed using the Review Manager software v5.

The effect of probiotics on gestational diabetes mellitus: an umbrella meta-analysis.

Background: Prior studies indicated the positive effects of probiotics on glycemic regulation in patients with gestational diabetes mellitus (GDM). Nonetheless, the results remain inconclusive. To address this, we conducted an umbrella meta-analysis to evaluate the impact of probiotics on glycemic indicators in GDM.

Supplementation with L-kynurenine during in vitro maturation improves bovine oocytes developmental competence through its antioxidative action.

Oxidative stress impairs the developmental potential of oocytes during in vitro maturation (IVM). L-kynurenine (L-KYN), an endogenous metabolite, exhibits antioxidant, anti-inflammatory and neuroprotective effects. This work aimed to evaluate the potential effects of L-KYN on bovine oocyte IVM and its mechanisms.

Spatiotemporal characteristics and socioeconomic inequalities in water, sanitation, and hygiene access in China from 2000 to 2020: analysis of data from three national censuses.

Background: Access to water, sanitation, and hygiene (WASH) facilities presents a significant global public health challenge. This study aims to investigate the temporal and spatial characteristics of WASH access in mainland China, as well as the socioeconomic equity, using data from national censuses.

Methods: We analyzed households' data from three national censuses spanning 2000 to 2020 to examine the characteristics of safe water, sanitary toilets, and hygiene bathing facilities over time.

Association of long-term exposure to air pollutants with sensory impairment in middle-aged and elderly adults: a nationwide study in China.

Few studies have examined the impact of ambient air pollutants on sensory impairments (SI) in adults. Using a nationally representative study of 13,505 participants from 125 Chinese cities, we investigated the association of air pollutants with SI among middle-aged and elderly adults. The SI were evaluated by self-reported visual impairment (VI) and/or hearing impairment.