A Nomogram Model for Predicting Clinical Pregnancy after Fresh IVF/ICSI-ET in Patients with Infertility and Endometriosis.

Objective: To determine the clinical and embryo laboratory factors that affect the clinical pregnancy rate of infertile patients with endometriosis (EMs), and establish a model for predicting clinical pregnancy.

Study Design: An observational study. Place and Duration of the Study: Reproductive Medicine Centre, Jiangxi Provincial Maternal and Child Health Hospital, China, from January 2016 to December 2023.

Integrating network pharmacology and animal experimental validation to investigate the mechanism of lotus leaf in obesity.

Background: Lotus leaf and its extracts have been reported to exert various beneficial effects; however, their anti-obesity mechanisms remain relatively unclear. Therefore, we investigated the mechanism by which lotus leaf regulates obesity using network pharmacology, molecular docking, and animal experimentation.

Methods: Network pharmacology was used to identify potential targets and pathways through which lotus leaf regulates obesity.

The Characteristics and Clinical Analysis of Lorenz Plot of Neonatal Atrial Tachycardia.

Background: Lorenz plot (LP) analysis enhances the accuracy of arrhythmia diagnosis and serves as an attractive diagnostic tool for patients with arrhythmias. We explored the utility of the LP in the classification of various types of neonatal atrial tachycardia and evaluated the treatment effects and prognosis.

Methods: Ninety-six newborns with atrial tachycardia had their dynamic electrocardiograms and clinical data collected between January 2018 and June 2023.

LncRNA-FGD5-AS1 promotes 5-Fu resistance of cervical cancer cells through modulating the miR-130a-3p-YTHDF2 axis.

Cervical cancer is one of the most common gynecologic malignancies worldwide. 5-Fluorouracil (5-Fu) is a widely used anticancer drug for various cancers, but the development of 5-Fu resistance poses a challenge in treating cervical cancer patients. This study examined the roles and molecular mechanisms of LncRNA-FGD5-AS1 in 5-Fu resistant cervical cancer cells through in vitro and in vivo experiments.

Anti-inflammatory properties of biflavonoids derived from Selaginella moellendorffii Hieron: Targeting NLRP3 inflammasome-dependent pyroptosis.

Ethnopharmacological Relevance: Selaginella moellendorffii Hieron. has been used as ethnic drug for chronic inflammation treatment. Biflavonoids represent a crucial class of bioactive compounds recognized for their potent anti-inflammatory activity in S.

Unveiling the therapeutic mechanisms of taraxasterol from dandelion in endometriosis: Network pharmacology and cellular insights.

Aims: Endometriosis is a chronic inflammatory disease. The current treatment options in clinical practice mainly include hormonal therapy and surgical intervention. However, hormonal therapy is associated with serious side effects, and surgical treatment often leads to a high recurrence rate.

Thromboembolic events associated with combined oral contraceptives: a real-world study based on the FDA adverse event reporting system (FAERS) database.

Background: The clinical characteristics and time-to-onset of thromboembolic events (TEEs) associated with combined oral contraceptives (COCs) remain unclear, our current study was committed to providing more data for risk evaluation and management of COCs treatment.

Research Design And Methods: This pharmacovigilance study was conducted in the FAERS database. We evaluated significant pharmacovigilance signals by using disproportionality analysis.

Photoactive gate material-based organic photoelectrochemical transistor sensors: working principle and representative applications.

Organic photoelectrochemical transistor (OPECT)-based sensors that use light-sensitive semiconductor materials as the gate have recently garnered increasing interest in various fields ranging from biological analysis to environmental monitoring. However, so far, the working principle and representative applications of OPECT sensors have not been discussed and reviewed systematically. In this review, we aim to present a comprehensive overview of the working principle and sensing mechanisms of OPECT-based sensors and various inorganic and organic photoactive gate materials used in OPECTs, with a focus on the representative applications and recent progress of these sensors in the fields of enzyme sensing, immunoassays, and nucleic acid-based sensing.

Genetic association of type 2 diabetes and antidiabetic drug target with skin cancer.

Background: Several observational studies have suggested that type 2 diabetes (T2D) is a risk factor for skin cancer, and antidiabetic drugs may reduce skin cancer risk. Nevertheless, the findings remain ambiguous. This Mendelian randomization (MR) study aimed to investigate the causal association of T2D with skin cancer and evaluate the potential impact of antidiabetic drug targets on skin cancer.

Gestational diabetes mellitus and risk of neonatal respiratory distress syndrome: a systematic review and meta-analysis.

Aim: Gestational Diabetes Mellitus (GDM), a common pregnancy complication characterized by glucose intolerance, is increasingly recognized as a risk factor for Neonatal Respiratory Distress Syndrome (NRDS). This study aimed to systematically review and quantify the association between GDM and NRDS.

Methods: A comprehensive search was conducted in PubMed, Scopus, Embase, and Web of Science from their inception through July 30, 2024, to identify relevant studies.

Maternal exposure to fine particulate matter in the air and risk for fetal congenital heart defects: a case-control study.

Prior research into the association between fine particulate matter (PM) exposure and the risk for fetal congenital heart defect (CHD) has yielded inconclusive and conflicting results. More epidemiologic evidence from different regions is necessary. A case-control study was conducted with 360 CHD cases and 3600 healthy newborns.

Genetic analysis and counseling of ADPKD caused by novel heterozygous mutations of in two Chinese families: Case report.

Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease, characterized by the progressive formation of multiple cysts in both kidneys, destruction of the renal structure, changes in renal function and eventually leading to end-stage renal failure and renal transplantation. In our study, Whole-exome sequencing (WES) was used to identify the responsible mutation of ADPKD in two unrelated Chinese PKD families. The WES revealed three variants in the gene, c.

Impact of physical indicators on ocular development in preschool children.

Objective: Understanding the impact of early childhood physical growth on visual development is crucial, as this period marks a critical phase for foundational physical and ocular maturation. The aim of the current study was to investigate the associations between the anthropometric indicators of height, weight, and body mass index (BMI), as well as visual acuity, refraction, and ocular biometrics, in Chinese preschool children.

Methods: This cross-sectional study consisted of 1,477 Chinese 3- to 6-year-old preschool children from nine kindergartens in Tongzhou District, Beijing.

Ozone promotes macrophage efferocytosis and alleviates neuropathic pain by activating the AMPK/Gas6-MerTK/SOCS3 signaling pathway.

Background: Neuropathic pain (NPP) is a multifaceted pain syndrome that occurs as a consequence of physical injury or underlying diseases, with an incidence rate of 7%-10%, NPP poses a significant clinical challenge as current treatment options are ineffective. The accumulation of apoptotic cells and neuroinflammation play crucial roles in the pathological mechanisms of NPP. Here, we aim to investigate strategies for effectively clearing apoptotic cells and provide therapeutic interventions for NPP.

[ Decoction alleviates ulcerative colitis in mice by reducing endoplasmic reticulum stress].

Objective: To evaluate the therapeutic effect of Decoction (HQD) on ulcerative colitis (UC) in mice and explore its mechanism.

Methods: Male Balb/c mice were randomly divided into normal control group, model group, mesalazine group (5-ASA, 200 mg/kg), and low-, medium-and high-dose HQD groups (2.275, 4.

A new pathway for ferroptosis regulation: The PRMTs.

Protein arginine methyltransferases (PRMTs) play an essential role in the regulation of ferroptosis, a form of programmed cell death characterized by abnormal iron ion metabolism, lipid peroxidation, and DNA damage. Through methylation, PRMTs modify specific proteins, thereby altering their activity, localizations, or interactions with other molecules to control the ferroptosis process. This study was conducted to provide a comprehensive overview of the relationship between PRMTs and ferroptosis, with a focus on the mechanisms by which PRMTs regulate ferroptosis and their effect on this cell death pathway.

Identification and validation of ATP6V1G1-regulated phosphorylated proteins in hepatocellular carcinoma.

V-ATPase Subunit G1 (ATP6V1G1) is one of the subunits of Vacuolar ATPases. Previous studies have indicated that ATP6V1G1 plays important roles in hepatocellular carcinoma (HCC) and is associated with HCC progression. However, the effect of ATP6V1G1 in HCC requires further elucidation.

Arenobufagin Induces Ferroptosis in Glioblastoma Cells via Modulating the MiR-149-5p/AEBP1 Axis.

Accumulating evidences have proved Arenobufagin (ArBu) exhibited cytotoxic effects to multiple types of cancer. However, in glwioblastoma (GBM), which is easy to develop resistance to classic chemotherapy reagent, the therapeutic effects of ArBu have not been explored. In the current study, we found that GBM cells were sensitive to ArBu treatment and ArBu induced cell death both in a dose-dependent and a time-dependent manner.

Ginsenoside RK3 inhibits glioblastoma by modulating macrophage M2 polarization via the PPARG/CCL2 axis.

Background: Glioblastoma is recognized as the most aggressive form of intracranial tumor, presenting significant challenges in treatment. Recent emphasis has been placed on the potential of traditional Chinese medicine (TCM) as an adjuvant treatment for cancer.

Methods: We employed a series of assays-including CCK8, EdU, Transwell, and neurosphere formation-to evaluate the impact of ginsenoside RK3 on the phenotype of GBM.

Additive interaction of pre-pregnancy BMI and assisted reproductive technology on the risk of pregnancy-induced hypertension.

Objective: To explore the combined effect of pre-pregnancy body mass index (BMI) and assisted reproductive technology (ART) on the risk of pregnancy-induced hypertension (PIH).

Methods: This retrospective cohort study included 3,220,103 women with singleton pregnancies from the National Vital Statistics System database for 2021. The outcome was the occurrence of PIH.

Application of bronchoalveolar lavage fluid cytomorphology in diagnosing Nocardia otitidiscaviarum: a case report.

Background: Nocardiosis is a rare infectious disease, which is frequently underdiagnosed because of the distinct bacterial shape of the causative agent and its developmental history. The morphological analysis of bronchoalveolar lavage fluid can facilitate the detection of pathogenic bacteria by observing cellular-bacterial interactions.

Case Presentation: An immunocompetent 67-year-old male patient of Asian ethnicity developed a cough without apparent cause 20 days earlier.