Using Social Media to Promote Life Skills Among Adolescents: A Debate on Opportunities, Challenges, and Implications for Health and Education.

The digitalization of society increasingly blurs boundaries between analog and digital worlds, offering opportunities such as telemedicine and global connectivity through digital platforms. However, it also presents risks, including cyberbullying, addiction potential, harmful content, misinformation, and privacy concerns from data breaches and surveillance technologies. Social media, with its global reach, amplifies both opportunities for positive engagement and the responsibility to navigate largely unregulated content.

In vitro evaluation of antimicrobial photodynamic therapy with photosensitizers and calcium hydroxide on bond strength, chemical composition, and sealing of glass-fiber posts to root dentin.

Investigate the impact of antimicrobial photodynamic therapy (aPDT) using different photosensitizers (PSs) such as indocyanine green (IG), curcumin (CC), and methylene blue (MB), with or without intracanal application of calcium hydroxide (CH), on the push-out bond strength of glass-fiber posts (GFPs) to intraradicular dentin, the chemical composition of the root substrate, and the sealing of the adhesive interface across different thirds of intraradicular dentin. A total of 112 bovine teeth underwent biomechanical preparation and were divided into eight experimental groups (n = 14 each): Negative control with deionized water; positive control with deionized water + CH; IG group with indocyanine green and infrared laser; IG + CH group; CC group with curcumin and blue LED; CC + CH group; MB group with methylene blue and red laser; and MB + CH group. The push-out bond strength was measured using a universal testing machine (n = 8), and scanning electron microscopy characterized the fracture patterns.

The (Im)Material Home: Exploring Older Migrants' Home Experiences Situated within Material and Immaterial Settings of Home. An Exploratory Study in Belgium.

The older population is diversifying. Extensive research has shown the preference of older adults to age in place. Recent research shows that older migrants also prefer to age in place.

A rare case of steroid-resistant nephrotic syndrome complicated by Wernicke's encephalopathy.

Wernicke's encephalopathy (WE) is a severe neurological condition caused by the deficiency of thiamine, which is a vitamin B1 molecule. Herein, we present the case of a 3-year-old girl with steroid-resistant nephrotic syndrome (SRNS) who did not achieve remission despite steroid pulse therapy (MPT) and rituximab. She had frequent vomiting and decreased oral intake on the 61st day.

Estimation of surface doses in the presence of an air gap under a bolus for a 6 MV clinical photon beam - a phantom study.

Goal of the present study was to develop and build a phantom that replicates the air gaps under a gel bolus and to estimate the surface dose (D) under normal incidence with a 6 MV photon beam. For this, an acrylic phantom with 10 plates, each including five open slots (one in the centre and four off axis) with a size of 2 cm × 2 cm at depths of 0.54 cm, 0.

International Urogynecology Consultation Chapter 3 Committee 1 - Pessary Management.

Introduction And Hypothesis: This manuscript is part of the International Urogynecological Consultation (IUC) on Pelvic Organ Prolapse (POP), Chapter 3, Committee 1 focusing on pessary management of POP.

Methods: A narrative review was conducted by an international, multi-disciplinary group of clinicians working in the field of pelvic health following a search of the literature using the MeSH terms "pelvic organ prolapse" OR "urogenital prolapse" OR "vaginal prolapse" OR "uterovaginal prolapse" AND "pessary" OR "support device" OR "intravaginal device." Relevant studies, as determined after review using the Covidence manuscript review platform, were included.

Combining clinical and radiological features improves prediction of bowel ischemia in patients with CT findings of pneumatosis intestinalis.

Background: Pneumatosis intestinalis on CT presents a diagnostic dilemma, because it could reflect bowel ischemia or benign finding.

Purpose: To determine radiological and clinical features that can predict bowel ischemia in patients with pneumatosis intestinalis on CT.

Materials And Methods: Patients with "pneumatosis" in abdominal CT reports performed between 1/1/2002 and 12/31/2018 were retrospectively included.

Dual-energy CT iodine concentration as a biomarker for immunotherapy treatment response in metastatic melanoma and renal cell carcinoma patients.

Objective: To investigate the predictive value of tumor iodine concentration obtained with dual-energy CT (DECT) for treatment response in patients treated with immune checkpoint inhibitors (ICI).

Materials And Methods: Retrospective single-center study of consecutive metastatic melanoma and renal cell carcinoma (RCC) patients undergoing first-line ICI treatment. The iodine concentration measurement time points include prior to initiation of therapy (baseline [BL]), after initiation (follow-up [FU1]), and either time point nearest to 12 months or at time of progression (final follow-up [FFU]).

[HEW score-a tool for the homogenisation of donor registrations to the DSO : Multicentre retrospective analysis of three university hospitals].

Background: The persistently low number of postmortem organ donations in Germany has repeatedly led to political discussions and most recently to the amendment of the Transplantation Act with the strengthening of the role of the transplantation officer and the introduction of a register to document the will to donate. The background to these decisions was the assumption that a relevant proportion of potential organ donors in hospitals were being overlooked and not reported. However, due to the lack of guidelines as to when a potential organ donor must be reported to the DSO ("Deutsche Stiftung Organspende"), the existing data is only of limited validity.

[WHO classification of melanocytic tumours].

Background: The update of the World Health Organisation (WHO) classification of skin tumours has led to new aspects in the classification of melanocytic tumours.

Objectives: Presentation of the classification of melanocytic tumours in light of current clinical, histological and genetic data.

Materials And Methods: Review of the classification of melanocytic neoplasms in the fifth edition of the WHO classification of skin tumours, taking into account current disease concepts.

Diffusion tensor imaging features of white matter pathways in the brain after COVID-19 infection.

Purpose: To determine whether there is a difference in apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values in white matter pathways in the subacute period after COVID-19 infection and to evaluate the correlation between diffusion tensor imaging (DTI) metrics and laboratory findings.

Material And Methods: The study included 64 healthy controls and 91 patients. Patients were classified as group 1 (all patients, n = 91), group 2 (outpatients, n = 58), or group 3 (inpatients, n = 33).

[F]PSMA-1007 PET/CT-based radiomics may help enhance the interpretation of bone focal uptakes in hormone-sensitive prostate cancer patients.

Purpose: We hypothesised that applying radiomics to [F]PSMA-1007 PET/CT images could help distinguish Unspecific Bone Uptakes (UBUs) from bone metastases in prostate cancer (PCa) patients. We compared the performance of radiomic features to human visual interpretation.

Materials And Methods: We retrospectively analysed 102 hormone-sensitive PCa patients who underwent [F]PSMA-1007 PET/CT and exhibited at least one focal bone uptake with known clinical follow-up (reference standard).

Fast and interpretable mortality risk scores for critical care patients.

Objective: Prediction of mortality in intensive care unit (ICU) patients typically relies on black box models (that are unacceptable for use in hospitals) or hand-tuned interpretable models (that might lead to the loss in performance). We aim to bridge the gap between these 2 categories by building on modern interpretable machine learning (ML) techniques to design interpretable mortality risk scores that are as accurate as black boxes.

Material And Methods: We developed a new algorithm, GroupFasterRisk, which has several important benefits: it uses both hard and soft direct sparsity regularization, it incorporates group sparsity to allow more cohesive models, it allows for monotonicity constraint to include domain knowledge, and it produces many equally good models, which allows domain experts to choose among them.

Patterns of willingness to share health data with key stakeholders in US consumers: a latent class analysis.

Objective: To identify distinct patterns in consumer willingness to share health data with various stakeholders and analyze characteristics across consumer groups.

Materials And Methods: Data from the Rock Health Digital Health Consumer Adoption Survey from 2018, 2019, 2020, and 2022 were analyzed. This study comprised a Census-matched representative sample of U.

Evaluating robustly standardized explainable anomaly detection of implausible variables in cancer data.

Objectives: Explanations help to understand why anomaly detection algorithms identify data as anomalous. This study evaluates whether robustly standardized explanation scores correctly identify the implausible variables that make cancer data anomalous.

Materials And Methods: The dataset analyzed consists of 18 587 truncated real-world cancer registry records containing 8 categorical variables describing patients diagnosed with bladder and lung tumors.

Facet-controlled electrosynthesis of nanoparticles by combinatorial screening in scanning electrochemical cell microscopy.

Controlled synthesis of faceted nanoparticles on surfaces without explicit use of ligands has gained attention due to their promising applications in electrocatalysis and chemical sensing. Electrodeposition is a desirable method; however, precise control over their size, spatial distribution, and morphology requires extensive optimization. Here, we report the spatially resolved synthesis of shape-controlled Pt nanoparticles and fast screening of synthesis conditions in scanning electrochemical cell microscopy (SECCM) with pulse potentials.

Infrared Ion Spectroscopy of Gaseous [Cu(2,2'-Bipyridine)]: Investigation of Jahn-Teller Elongation Versus Compression.

Symmetry breaking is ubiquitous in chemical transformations and affects various physicochemical properties of materials and molecules; Jahn-Teller (JT) distortion of hexa-coordinated transition-metal-ligand complexes falls within this paradigm. An uneven occupancy of degenerate 3d-orbitals forces the complex to adopt an axially elongated or compressed geometry, lowering the symmetry of the system and lifting the degeneracy. Coordination complexes of Cu are known to exhibit axial elongation, while compression is far less common, although this may be due to the lack of rigorous experimental verification.

Chinese herbal medicine-inspired construction of multi-component hydrogels with antibacterial and wound-healing-promoting functions.

Chinese herbal medicine (CHM) has offered a great treasure and source of inspiration for developing innovative medicinal materials and therapy. In this work, inspired by the macroscopic compatibility of and in CHM, the puerarin (PUE) and CaSO (Ca) as the main constituents, respectively, from the two herbs are co-assembled into two-component molecular hydrogels. Such two-component gels exhibited enhanced mechanical properties compared with the single-component PUE gel due to the introduction of crosslinking hydrogen bonds between PUE and Ca.

Between-day variability of soleus H reflex recruitment curve parameters: how many stimulations are required to maximise the reproducibility of the measurements?

Purpose: The H reflex recruitment curve represents the gold standard for quantifying changes in spinal circuitries. However, there is no agreement on how many stimulations should be applied for each parameter. Thus, we explored the impact of varying the number of stimulations (3, 6, 9, 12 and 15 stimuli per intensity) on between-day reliability of soleus H reflex.

Multicolor emission from a 0D-doped hybrid halide (CHN)CdBr single crystal.

Achieving multicolor emission is a fascinating goal that remains challenging for zero-dimensional (0D) hybrid halides. We successfully obtained a three-millimeter-scale 0D (MXDA)CdBr (MXDA = CHN) single crystal (SC) by the solvothermal method. It serves as an outstanding host for doping with various valence activators, such as Cu, Mn and Sb, and these doped single crystals emit blue (470 nm), yellow (580 nm) and red (618 nm) fluorescence, which accurately cover a large visible region and achieve efficient multicolor emission.

Heterogeneous Frustrated Lewis Pair Catalysts: Rational Structure Design and Mechanistic Elucidation Based on Intrinsic Properties of Supports.

ConspectusThe discovery of reversible hydrogenation using metal-free phosphoborate species in 2006 marked the official advent of frustrated Lewis pair (FLP) chemistry. This breakthrough revolutionized homogeneous catalysis approaches and paved the way for innovative catalytic strategies. The unique reactivity of FLPs is attributed to the Lewis base (LB) and Lewis acid (LA) sites either in spatial separation or in equilibrium, which actively react with molecules.

Machine Learning Interatomic Potential for Modeling the Mechanical and Thermal Properties of Naphthyl-Based Nanotubes.

Two-dimensional (2D) nanomaterials are at the forefront of potential technological advancements. Carbon-based materials have been extensively studied since synthesizing graphene, which revealed properties of great interest for novel applications across diverse scientific and technological domains. New carbon allotropes continue to be explored theoretically, with several successful synthesis processes for carbon-based materials recently achieved.

Fabrication of Hypoxia-Mimicking Supramolecular Hydrogels for Cartilage Repair.

Despite advancements in chronic arthritis treatment, there remains a significant demand for advanced nanotechnologies capable of efficiently delivering a wide range of therapeutic agents to provide symptomatic relief and facilitate the healing of inflamed cartilage tissue. Considering the significant impact of hypoxia on the development and maintenance of chondral tissue, replicating its effects on stem cells could be a potential approach for the treatment of osteoarthritis (OA). Cobalt is a prominent hypoxia-inducing agent, owing to its ability to activate the hypoxia-inducible factor (HIF) pathway regardless of cellular oxygen levels.

Study on the Influence of External Electric Field Control and Vibrational Quantum Effect on the Charge Separation Mechanism in Fullerene-Based Systems.

Based on the DCV-C system of fullerene acceptor organic solar cell active materials, the charge transfer process of D-A type molecular materials under the action of an external electric field () was explored. Within the range of electric field application, the excited state characteristics exhibit certain regular changes. Based on reducing the excitation energy, the excitation mode shows a trend of developing toward low excited states.

Symmetry Breaking: Case Studies with Organic Cage-Racemates.

ConspectusSymmetry is a pervasive phenomenon spanning diverse fields, from art and architecture to mathematics and science. In the scientific realms, symmetry reveals fundamental laws, while symmetry breaking─the collapse of certain symmetry─is the underlying cause of phenomena. Research on symmetry and symmetry breaking consistently provides valuable insights across disciplines, from parity violation in physics to the origin of homochirality in biology.