The impact of repeated mass antigen testing for COVID-19 on the prevalence of the disease.

In the absence of effective vaccination, mass testing and quarantining of positive cases and their contacts could help to mitigate pandemics and allow economies to stay open. We investigate the effects of repeated mass testing on the COVID-19 pandemic caused by the SARS-CoV-2 virus, using data from the first ever nationwide rapid antigen testing implemented in Slovakia in autumn 2020. After the first round of testing, only districts above an ex ante unknown threshold of test positivity were re-tested.

Can wood-decaying urban macrofungi be identified by using fuzzy interference system? An example in Central European Ganoderma species.

Ganoderma is a cosmopolitan genus of wood-decaying basidiomycetous macrofungi that can rot the roots and/or lower trunk. Among the standing trees, their presence often indicates that a hazard assessment may be necessary. These bracket fungi are commonly known for the crust-like upper surfaces of their basidiocarps and formation of white rot.

Tailoring the optical and dynamic properties of iminothioindoxyl photoswitches through acidochromism.

Multi-responsive functional molecules are key for obtaining user-defined control of the properties and functions of chemical and biological systems. In this respect, pH-responsive photochromes, whose switching can be directed with light and acid-base equilibria, have emerged as highly attractive molecular units. The challenge in their design comes from the need to accommodate application-defined boundary conditions for both light- and protonation-responsivity.

Reactivity of the Superheavy Element 115, Mc, and Its Lighter Homologue, Bi, with Respect to Gold and Hydroxylated Quartz Surfaces from Periodic Relativistic DFT Calculations: A Comparison with Element 113, Nh.

Adsorption energies () of the superheavy element (SHE) Mc, its lighter homologue (Bi), as well as of another superheavy element Nh and some lighter homologues of SHEs on gold and hydroxylated quartz surfaces are predicted via periodic relativistic density functional theory calculations. The aim of this study is to support "one-atom-at-a-time" gas-phase chromatography experiments that are examining the reactivity and volatility of Mc. The obtained values of the Bi and Mc atoms on the Au(111) surface are >200 kJ/mol.

Frailty in Nonalcoholic Fatty Liver Cirrhosis: A Comparison with Alcoholic Cirrhosis, Risk Patterns, and Impact on Prognosis.

Background: Physical frailty increases susceptibility to stressors and predicts adverse outcomes of cirrhosis. Data on disease course in different etiologies are scarce, so we aimed to compare the prevalence and risk factors of frailty and its impact on prognosis in nonalcoholic fatty liver (NAFLD) and alcoholic (ALD) cirrhosis. .

The Use of Diagnosis-Related Group-Based Reimbursement in the Czech Hospital Care System.

(1) Background: Diagnosis-Related Groups (DRG), one possibility of a hospital payment system, are currently used in most European countries. Introduced to the Czech system in the 1990s, the DRGs are currently used mainly for care reporting and partly for reimbursement. According to most experts, the use of DRG remain controversial.

Global data on earthworm abundance, biomass, diversity and corresponding environmental properties.

Earthworms are an important soil taxon as ecosystem engineers, providing a variety of crucial ecosystem functions and services. Little is known about their diversity and distribution at large spatial scales, despite the availability of considerable amounts of local-scale data. Earthworm diversity data, obtained from the primary literature or provided directly by authors, were collated with information on site locations, including coordinates, habitat cover, and soil properties.

Does the chronotype distribution vary between different level football leagues? Insights gained from Czech elite football players.

Chronotype refer to individuals' time-of-day preferences for activities, which can be classified as "morning types = (M-types)", "evening types = (E-types)", and "neither types (N-types)". The primary aim of this study was to compare the chronotype distribution of Czech First League (1L) and Czech National Football League (2L) male elite football players, which was divided into two secondary aims: (i) statistically identify and compare the number (presence) of particular chronotypes in 1L, and (ii) statistically identify and compare the number (presence) of particular chronotypes in 2L. The present cross-sectional study employed a self-reported standardized questionnaire, the Composite Scale of Morningness, to study the chronotype distribution among the male elite football players.

Challenging management of severe chronic disorders in acute pandemic situation: Chronic liver disease under COVID-19 pandemic as the proof-of-principle model to orchestrate the measures in 3PM context.

Chronic liver disease management is a comprehensive approach requiring multi-professional expertise and well-orchestrated healthcare measures thoroughly organized by responsible medical units. Contextually, the corresponding multi-faceted chain of healthcare events is likely to be severely disturbed or even temporarily broken under the force majeure conditions such as global pandemics. Consequently, the chronic liver disease is highly representative for the management of any severe chronic disorder under lasting pandemics with unprecedented numbers of acutely diseased persons who, together with the chronically sick patient cohorts, have to be treated using the given capacity of healthcare systems with their limited resources.

Polyradical PROXYL/TEMPO Conjugates Connected by Ester/Amide Bridges: Synthesis, Physicochemical Studies, and DFT Calculations.

A series of di-/trinitroxide esters and amides featuring PROXYL and/or TEMPO radicals connected with alicyclic bridges were prepared in 61-92 % yields and their properties were analysed by using multiple experimental techniques. The examination of EPR spectra of radicals in organic solvents augmented with DFT calculations brought valuable information on the conformational dynamics and spin exchange mechanisms. Cyclic voltammetry investigations revealed (quasi)reversible electrochemical behaviour of studied nitroxides with their half-wave potentials ranging from -51 to -17 mV.

Mercury in fish tissues in the area of Malachov Hg-ore deposit (Slovakia).

The abandoned Malachov deposit belongs among the most important historic Hg deposits in the world. The soil, groundwater, surface water, plants, and animals are still heavily contaminated by potentially toxic elements such as As and Cd, but mainly by Hg. This article is focused on the Hg contamination of aquatic plants and animals in the Malachov creek.

In Search of Concerted Strategies for Competitive and Resilient Regions.

The European space-economy represents a complex system with a great internal heterogeneity, intensive socioeconomic interactions and differential growth trajectories among countries and regions. The present study aims to investigate the connectivity between spatial competitiveness and resilience in Europe and seeks to design an operational framework for concerted strategies of competitive and resilient regions. To assess the linkage between resilience and competitiveness, we have developed a new measure, viz.

Fast and Sensitive Screening of Oxandrolone and Its Major Metabolite 17-Epi-Oxandrolone in Human Urine by UHPLC-MS/MS with On-Line SPE Sample Pretreatment.

Oxandrolone, a synthetic testosterone analog, is used for the treatment of several diseases associated with weight loss. Unfortunately, oxandrolone is abused by many athletes and bodybuilders due to its strong anabolic effect. We have developed and validated a highly sensitive and rapid on-line SPE-UHPLC-MS/MS method for the determination of oxandrolone and simultaneous identification of its major metabolite 17-epi-oxandrolone in urine matrices.

General Principles for the Design of Visible-Light-Responsive Photoswitches: Tetra-ortho-Chloro-Azobenzenes.

Molecular photoswitches enable reversible external control of biological systems, nanomachines, and smart materials. Their development is driven by the need for low energy (green-red-NIR) light switching, to allow non-invasive operation with deep tissue penetration. The lack of clear design principles for the adaptation and optimization of such systems limits further applications.

Adherence to Oral Nutritional Supplements After Being Discharged from the Hospital is Low but Improves Outcome in Patients with Advanced Chronic Liver Disease.

Purpose: Patients with advanced chronic liver disease (ACLD) often have a poor nutritional status. In the management, current guidelines recommend dietary counseling and oral nutritional supplements (ONS). Nutritional goals and adherence to ONS are difficult to achieve while studies addressing adherence are scarce.

Removal of Nickel from Aqueous Solutions by Natural Bentonites from Slovakia.

In this study, the removal of nickel (Ni(II)) by adsorption from synthetically prepared solutions using natural bentonites (Lieskovec (L), Hliník nad Hronom (S), Jelšový Potok (JP), and Stará Kremnička (SK)) was investigated. All experiments were carried out under batch processing conditions, with the concentration of Ni(II), temperature, and time as the variables. The adsorption process was fast, approaching equilibrium within 30 min.

Effects of Natural Sorbents on the Germination and Early Growth of Grasses on Soils Contaminated by Potentially Toxic Elements.

The reclamation of abandoned mining heaps rich in potentially toxic elements (PTEs) is critical for the environment. We carried out a laboratory experiment studying the effects of the addition of four natural sorbents (biochar, bentonite, chicken manure and organo-zeolitic substrate) to soils contaminated with PTEs, predominantly Cu, As and Sb, on the germination and growth of the autochthonous grasses and . The experiment used Petri dish tests with water extracts of contaminated soil and soil neutralised with the four sorbents.

Accurate Nonlinear Optical Properties of Solvated -Nitroaniline Predicted by an Electrostatic Discrete Local Field Approach.

A general computational protocol for accurate predictions of nonlinear optical (NLO) properties of solvated molecules based on the rigorous local field (RLF) approach taking all relevant effects into account is presented. -Nitroaniline (pNA) was taken as a model NLO system dissolved in cyclohexane, tetrahydrofuran, and 1,4-dioxane. Molecular dynamics (MD) simulations employing either non-polarizable or polarizable force fields were used to generate representative sets of structures of the solutions.

Diurnal variation in red blood cell variables in athletes after single and repeated bouts of exercise.

Background: The aim of this study was to examine the diurnal and exercise-related changes in red blood cell variables which serve as indirect markers of doping in sports.

Methods: Ten men and 7 women, all undoped highly trained endurance athletes aged 19-34 years, were included in the study. Before and on the day with single and repeated bouts of exercise, blood samples were collected at 07:00, 09:00, 13:00, 18:00, and 21:00, at least 2 hours after exercise.

Subfossil chironomids (Diptera, Chironomidae) of lakes in the Tatra Mountains: an illustrated guide.

Here we present a summary of subfossil chironomids (Diptera: Chironomidae) found in the surface sediments of 52 Tatra Mts. lakes (Slovakia, Poland). Head capsules of 73 morphotypes of 5 subfamilies are described and illustrated.

Body Fat Mediates Association between Active Living and Health among Adolescents.

The aim of this study was to explore the association of moderate-to-vigorous physical activity and organized leisure-time activities with self-rated health among adolescents and whether these associations are mediated by body fat percentage. We used data on 888 adolescents (mean age 12.97, SD 1.

Reaction of the Organisms of Young Football Players to City Smog in the Sports Training.

The essence of a sports training includes not only developing the skills necessary in a chosen sport but also particular care about athlete's health. This issue should be taken into account especially in case of children and youth engaged in sporting activities. In the paper there are issues connected to the control of physical effort abilities in the sports training of young football players and the assessment of the reaction of the body to physical exercise in city smog conditions (the environment of the city of Kraków) and clean air conditions (the environment of the town of Głuchołazy).

Highly Cooperative Photoswitching in Dihydropyrene Dimers.

We present a strategy to achieve highly cooperative photoswitching, where the initial switching event greatly facilitates subsequent switching of the neighboring unit. By linking donor/acceptor substituted dihydropyrenes via suitable π-conjugated bridges, the quantum yield of the second photochemical ring-opening process could be enhanced by more than two orders of magnitude as compared to the first ring-opening. As a result, the intermediate mixed switching state is not detected during photoisomerization although it is formed during the thermal back reaction.

Competition in Public Procurement in the Czech and Slovak Public Health Care Sectors.

Sustainability of health financing is a critical issue for all countries, especially now in the COVID-19 period. The final level of achievements of critical public health goals is connected not only with the efforts of the people involved, but also with the availability of funding to cover the costs of the actions needed. One of the "internal sources" providing more resources to cover public health care costs is effective public procurement in the health care sector.

The fox tapeworm, , in grey wolves and dogs in Slovakia: epidemiology and genetic analysis.

Echinococcus multilocularis, the causative agent of human alveolar echinococcosis, is an important emerging parasite in the northern hemisphere. In epidemiological studies, the highest attention is being paid to foxes as the main reservoir hosts responsible for geographic expansion from multiple focal populations and the invasion of urban habitats, but little information is available on the parasite distribution in other carnivores. Hence, the study was designed to obtain updated information about the occurrence and genetic diversity of E.