43 results match your criteria: "Massachusetts2Harvard Medical School[Affiliation]"

Childhood Lead Exposure and Adult Outcomes.

JAMA

March 2017

Boston Children's Hospital, Boston, Massachusetts2Harvard Medical School, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

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Step Therapy-Clinical Algorithms, Legislation, and Optimal Prescribing.

JAMA

February 2017

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts2Harvard Medical School, Boston, Massachusetts.

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Preparing for the Next Terrorism Attack: Lessons From Paris, Brussels, and Boston.

JAMA Surg

May 2017

Urgente de Paris Hôpital Necker-Enfants Malades, Paris France7Assistance Publique Hôpitaux de Paris, Paris, France8Paris Descartes University, Paris, France.

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Importance: Subclinical inflammatory demyelination and neurodegeneration often precede symptom onset in multiple sclerosis (MS).

Objective: To investigate the prevalence of brain magnetic resonance imaging (MRI) and subclinical abnormalities among asymptomatic individuals at risk for MS.

Design, Setting, And Participants: The Genes and Environment in Multiple Sclerosis (GEMS) project is a prospective cohort study of first-degree relatives of people with MS.

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What Van Halen Can Teach Us About the Care of Older Patients.

JAMA Intern Med

March 2017

Division of Geriatrics and Palliative Care, Veterans Affairs Boston HealthCare System New England GRECC (Geriatrics Research Education and Clinical Center), Boston, Massachusetts2Harvard Medical School, Boston, Massachusetts.

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Importance: Home aeroallergen exposure is associated with increased asthma morbidity in children, yet little is known about the contribution of school aeroallergen exposures to such morbidity.

Objective: To evaluate the effect of school-specific aeroallergen exposures on asthma morbidity among students, adjusting for home exposures.

Design, Setting, And Participants: The School Inner-City Asthma Study was a prospective cohort study evaluating 284 students aged 4 to 13 years with asthma who were enrolled from 37 inner-city elementary schools in the northeastern United States between March 1, 2008, and August 31, 2013.

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Firearm Laws and Firearm Homicides: A Systematic Review.

JAMA Intern Med

January 2017

Division of Emergency Medicine, Boston Children's Hospital, Boston, Massachusetts2Harvard Medical School, Boston, Massachusetts.

Importance: Firearm homicide is a leading cause of injury death in the United States, and there is considerable debate over the effectiveness of firearm policies. An analysis of the effectiveness of firearm laws on firearm homicide is important to understand optimal policies to decrease firearm homicide in the United States.

Objective: To evaluate the association between firearm laws and preventing firearm homicides in the United States.

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New Findings in Ventral Incisional Hernia Repair.

JAMA

October 2016

VA Boston Health Care System, Boston University, West Roxbury, Massachusetts2Harvard Medical School, Boston, Massachusetts.

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The Quality of Outpatient Care Delivered to Adults in the United States, 2002 to 2013.

JAMA Intern Med

December 2016

Harvard Medical School, Boston, Massachusetts3Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts4Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

Importance: Widespread deficits in the quality of US health care were described over a decade ago. Since then, local, regional, and national efforts have sought to improve quality and patient experience, but there is incomplete information about whether such efforts have been successful.

Objective: To measure changes in outpatient quality and patient experience in the United States from 2002 to 2013.

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The Supplement Paradox: Negligible Benefits, Robust Consumption.

JAMA

October 2016

Department of Internal Medicine, Cambridge Health Alliance, Cambridge, Massachusetts2Harvard Medical School, Boston, Massachusetts.

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Capitalizing on Advances in Science to Reduce the Health Consequences of Early Childhood Adversity.

JAMA Pediatr

October 2016

Center on the Developing Child at Harvard University, Cambridge, Massachusetts2Harvard Medical School, Harvard T. H. Chan School of Public Health, Boston, Massachusetts3Harvard Graduate School of Education, Cambridge, Massachusetts.

Advances in biology are providing deeper insights into how early experiences are built into the body with lasting effects on learning, behavior, and health. Numerous evaluations of interventions for young children facing adversity have demonstrated multiple, positive effects but they have been highly variable and difficult to sustain or scale. New research on plasticity and critical periods in development, increasing understanding of how gene-environment interaction affects variation in stress susceptibility and resilience, and the emerging availability of measures of toxic stress effects that are sensitive to intervention provide much-needed fuel for science-informed innovation in the early childhood arena.

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Chalky Vocal Fold Lesions.

JAMA Otolaryngol Head Neck Surg

February 2017

Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts2Harvard Medical School, Boston, Massachusetts.

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Perioperative Hearing Evaluations for Patients Undergoing Tympanostomy Tube Placement.

JAMA Otolaryngol Head Neck Surg

November 2016

Boston Children's Hospital, Department of Otolaryngology and Communication Enhancement, Boston, Massachusetts.

Importance: Obtaining hearing thresholds is an important step in the evaluation of a child with otitis media because decreased hearing in the presence of a chronic middle ear effusion factors into the decision to place tympanostomy tubes (TTs).

Objective: To provide evidence regarding appropriate use of perioperative hearing evaluations in conjunction with TTs.

Design, Setting, And Participants: Case series with medical record review of all patients aged 0 to 24 years who received TTs at a tertiary pediatric care facility from June 1, 2010, through June 1, 2011.

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Effect of Targeting Inflammation With Salsalate: The TINSAL-CVD Randomized Clinical Trial on Progression of Coronary Plaque in Overweight and Obese Patients Using Statins.

JAMA Cardiol

July 2016

Harvard Medical School, Boston, Massachusetts4Clinical Behavioral and Outcomes Research, Joslin Diabetes Center, Boston, Massachusetts8Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

Importance: Inflammation may contribute to pathological associations among obesity, diabetes mellitus, and cardiovascular disease.

Objective: To determine whether targeting inflammation using salsalate compared with placebo reduces progression of noncalcified coronary artery plaque.

Design, Setting, And Participants: In the Targeting Inflammation Using Salsalate in Cardiovascular Disease (TINSAL-CVD) trial participants were randomly assigned between September 23, 2008, and July 5, 2012, to 30 months of salsalate or placebo in addition to standard, guideline-based therapies.

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Innovative Approaches for Modifying Surgical Culture.

JAMA Surg

September 2016

Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles4VA Greater Los Angeles Healthcare System, Los Angeles, California.

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Importance: Dual antiplatelet therapy after percutaneous coronary intervention (PCI) reduces ischemia but increases bleeding.

Objective: To develop a clinical decision tool to identify patients expected to derive benefit vs harm from continuing thienopyridine beyond 1 year after PCI.

Design, Setting, And Participants: Among 11,648 randomized DAPT Study patients from 11 countries (August 2009-May 2014), a prediction rule was derived stratifying patients into groups to distinguish ischemic and bleeding risk 12 to 30 months after PCI.

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Critical Care and the Brain.

JAMA

February 2016

Division of Anaesthesia, Clinical School, University of Cambridge, Cambridge, United Kingdom4Addenbrooke's Hospital, Cambridge, United Kingdom.

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