58 results match your criteria: "Massachusetts JKS; and Spaulding Rehabilitation Hospital[Affiliation]"

Computed tomography (CT) lung density is an accepted biomarker for emphysema in alpha-1 antitrypsin deficiency (AATD), although concerns for radiation exposure limit its longitudinal use. Serum proteins associated with emphysema, particularly in early disease, may provide additional pathogenic insights. We investigated whether distinct proteomic signatures characterize the presence and progression of emphysema in individuals with severe AATD and normal forced expiratory volume in 1 second (FEV).

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Women Physicians Are Underrepresented in Recognition Awards From the Association of Academic Physiatrists.

Am J Phys Med Rehabil

January 2018

From the Department of Physical Medicine and Rehabilitation, Harvard Medical School; Spaulding Rehabilitation Hospital; Massachusetts General Hospital; Brigham and Women's Hospital, Boston, Massachusetts (JKS); Department of Physical Medicine and Rehabilitation, Harvard Medical School; Spaulding Rehabilitation Hospital; Brigham and Women's Hospital, Boston, Massachusetts (CAB, AST); Department of Physical Medicine and Rehabilitation, Harvard Medical School; Spaulding Rehabilitation Hospital; Massachusetts General Hospital; VA Boston Healthcare System, Boston, Massachusetts (SB); Department of Physical Medicine and Rehabilitation, Harvard Medical School; Spaulding Rehabilitation Hospital, Boston, Massachusetts (CSS, RG, VG-K, JMR, NLM); Department of Physical Medicine and Rehabilitation, Harvard Medical School; Spaulding Rehabilitation Hospital; Massachusetts General Hospital, Boston, Massachusetts (JCS); and Department of Physical Medicine and Rehabilitation, Harvard Medical School; Medical Affairs, Research and Education, Spaulding Rehabilitation Network; Physical Medicine and Rehabilitation, Massachusetts General Hospital; Physical Medicine and Rehabilitation, Brigham and Women's Hospital, Boston, Massachusetts (RDZ).

Objective: Determine representation by gender for individual recognition awards presented to physicians by the Association of Academic Physiatrists (AAP).

Design: Cross-sectional survey was used. Lists of individual recognition award recipients for the 27-yr history of the AAP awards (1990-2016) were analyzed.

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Evaluating Disability Insurance Assistance as a Specific Intervention by Physiatrists at a Cancer Center.

Am J Phys Med Rehabil

July 2017

From the Department of Palliative, Rehabilitation & Integrative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas (JBF, MPO, BSK, AN-H, RY, EB); and Department of Physical Medicine & Rehabilitation, Harvard Medical School and Spaulding Rehabilitation Hospital, Boston, Massachusetts (JKS).

Because of their expertise, physiatrists provide disability insurance assistance for cancer survivors. In this brief report, we perform a descriptive retrospective analysis of all new (354) outpatient physiatry consultations from January 1, 2009, to December 31, 2013, at a National Cancer Institute Comprehensive Cancer Center. Disability and/or work accommodations were brought up at some point with the physiatrist during the duration of their care for 131 (37%) of 354 patients.

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Physician Burnout in Physical Medicine and Rehabilitation (PM&R): Should We Focus More on Physiatrists' Mission?

Am J Phys Med Rehabil

August 2017

From the Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital (JKS); and Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, VA Boston Healthcare System (SB), Boston, Massachusetts.

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Desmoteplase 3 to 9 Hours After Major Artery Occlusion Stroke: The DIAS-4 Trial (Efficacy and Safety Study of Desmoteplase to Treat Acute Ischemic Stroke).

Stroke

December 2016

From the Universitätsklinikum Carl Gustav Carus an der Technischen Universität, Dresden, Germany (R.v.K.); Tohoku University Graduate School of Medicine, Sendai, Japan (E.M.); H. Lundbeck A/S, Valby, Denmark (T.T., J.-K.S.J., B.A.G.); Center for Stroke Research Berlin, Charité-Universitätsmedizin Berlin, Germany (J.B.F.); University of Geneva, Switzerland (K.-O.L.); c IDIBGI. Hospital Dr Josep Trueta, UDG. Girona, Spain (S.P.); Department of Radiology, Harvard Medical School, Boston, MA (J.M.R.); Department of Neurology, Hopital Lariboisiere APHP, University Denis Diderot and INSERM U1161, DHU NeuroVasc, Paris, France (H.C.); Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, Taiwan (K.-C.C.); Department of Neurosciences Hospital Germans Trias i Pujol, Universitat Autonoma, Barcelona, Spain (A.D.); Oxford University Hospitals and Medical Sciences Division, University of Oxford, United Kingdom (G.A.F.); Memorial Hermann Hospital, Houston, TX (J.G.); Department of Neurology, Helsinki University Hospital, Clinical Neurosciences, Neurology, University of Helsinki, Finland (M.K.); Department of Neurology and Stroke Service, Massachusetts General Hospital, Harvard Medical School, Boston (L.H.S.); University of Alberta, Edmonton, Canada (A.S.); and Stanford University Medical Center, Palo Alto, CA (G.W.A.).

Background And Purpose: The DIAS-3 trial (Efficacy and Safety Study of Desmoteplase to Treat Acute Ischemic Stroke [phase 3]) did not demonstrate a significant clinical benefit of desmoteplase administered 3 to 9 hours after stroke in patients with major artery occlusion. We present the results of the prematurely terminated DIAS-4 trial together with a post hoc pooled analysis of the concomitant DIAS-3, DIAS-4, and DIAS-J (Japan) trials to better understand the potential risks and benefits of intravenous desmoteplase for the treatment of ischemic stroke in an extended time window.

Methods: Ischemic stroke patients with occlusion/high-grade stenosis in major cerebral arteries were randomly assigned to intravenous treatment with desmoteplase (90 μg/kg) or placebo.

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Basal Left Ventricular Dilatation and Reduced Contraction in Patients With Mitral Valve Prolapse Can Be Secondary to Annular Dilatation: Preoperative and Postoperative Speckle-Tracking Echocardiographic Study on Left Ventricle and Mitral Valve Annulus Interaction.

Circ Cardiovasc Imaging

October 2016

From the Second Department of Internal Medicine (S.F., H.K., T.M., Y.O., S.S., Y.O.), Departments of Laboratory and Transfusion Medicine (M.T.), and Cardiovascular Surgery (M.E., Y.N.), University of Occupational and Environmental Health, Kitakyushu, Japan; Cardiac Imaging Center, Asan Medical Center Heart Institute, Seoul, South Korea (J.-K.S., J.Y.J., B.J.S., J.K.); Departments of Cardiology (K.M., S.T.) and Cardiovascular Surgery (K.M., S.T.), Sakakibara Heart Institute, Fuchu, Japan; and Cardiac Ultrasound Laboratory, Massachusetts General Hospital, Boston (R.A.L.).

Background: Prominent mitral valve (MV) annular dilatation with only modest left ventricular (LV) dilatation in patients with MV prolapse (MVP) suggests predominant dilatation in adjacent basal LV, which may augment regional wall tension and attenuate contraction by Laplace's law. We hypothesized that MV annular dilatation in patients with MVP is associated with the basal predominance of LV dilatation and attenuated contraction, which can be altered by surgical MV plasty with annulus reduction.

Methods And Results: Echocardiography with speckle-tracking analysis to assess regional cross-sectional short-axis area and longitudinal contraction (strain) of basal, middle, and apical LV was performed in 30 controls and 130 patients with MVP.

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Analysis of MDM2 Amplification in 43 Endometrial Stromal Tumors: A Potential Diagnostic Pitfall.

Int J Gynecol Pathol

November 2015

Department of Laboratory Medicine and Pathology (J.K.S., A.P.S., P.T.G., J.C.H., G.L.K.), Mayo Clinic, Rochester, Minnesota Department of Pathology (P.D.C., M.R.N.), Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Boston, Massachusetts.

MDM2 amplification is known to occur in a variety of neoplasms and its detection by fluorescence in situ hybridization is helpful in distinguishing well-differentiated and dedifferentated liposarcoma from classic lipoma. We recently evaluated a mesenteric mass initially diagnosed as dedifferentiated liposarcoma, largely due to the neoplasm's myxoid morphology and MDM2 expression by immunohistochemistry, from a 46-yr-old woman with a history of uterine low-grade endometrial stromal sarcoma (LG-ESS) with a JAZF1 rearrangement. Our workup of the mesenteric mass revealed a JAZF1 rearrangement and a revised diagnosis of metastatic LG-ESS with myxoid change was rendered.

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Aortic valve adaptation to aortic root dilatation: insights into the mechanism of functional aortic regurgitation from 3-dimensional cardiac computed tomography.

Circ Cardiovasc Imaging

September 2014

From the Cardiac Imaging Center, Asan Medical Center Heart Institute, University of Ulsan College of Medicine, Seoul, South Korea (D.-H. Kim, B.J.S., J.Y.J., D.H.Y., J.-W.K., J.-M.S., D.-H. Kang, T.-H.L., J.-K.S.); and Cardiac Ultrasound Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA (M.D.H., R.A.L.).

Background: The 3-dimensional relationship between aortic root and cusp is essential to understand the mechanism of aortic regurgitation (AR) because of aortic root dilatation (ARD). We sought to test the hypothesis that the stretched cusps in ARD enlarge to compensate for ARD.

Methods And Results: Computed tomography imaged 92 patients (57 with ARD, 29 with moderate to severe AR, 28 without significant AR) and 35 normal controls.

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