3 results match your criteria: "Massachusetts Institute of Technology 77 Massachusetts Avenue Cambridge MA 02139 USA blp@mit.edu.[Affiliation]"
Article Synopsis
- HPV infections are responsible for nearly all cases of cervical cancer, which ranks as the fourth most common cancer among women globally.
- High-risk HPV variants like HPV16 promote cancer development by degrading the p53 tumor suppressor through the action of the E6 protein, which recruits E6AP to tag p53 for destruction.
- Researchers have created a covalent peptide inhibitor called reactide that targets cysteine 58 in HPV16 E6, potentially offering a new strategy to stop HPV-induced degradation of p53 and combat HPV-related cancers.
The synthesis of palladium oxidative addition complexes derived from unprotected peptides is described. Incorporation of 4-halophenylalanine into a peptide during solid phase peptide synthesis allows for subsequent oxidative addition at this position upon treatment with a palladium precursor and suitable ligand. The resulting palladium-peptide complexes are solid, storable, water-soluble, and easily purified high-performance liquid chromatography.
View Article and Find Full Text PDFIn-solution affinity selection (AS) of large synthetic peptide libraries affords identification of binders to protein targets through access to an expanded chemical space. Standard affinity selection methods, however, can be time-consuming, low-throughput, or provide hits that display low selectivity to the target. Here we report an automated bio-layer interferometry (BLI)-assisted affinity selection platform.
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