903 results match your criteria: "MassGeneral Hospital for Children[Affiliation]"

Objectives: To evaluate if the tackler correctly adhering, or not, to four different instructions of legal front-on one-on-one torso tackles altered the tackler and/or ball carrier peak inertial head kinematics.

Design: Controlled laboratory study.

Methods: Fifteen rugby-code players measured with three-dimensional optoelectronic motion capture performed two tackle instructions from the Australian National Rugby League coaching manual on under (Dominant National Rugby League) and over (Smother National Rugby League) the ball tackles, and two novel variants of these (under, Dominant, Torso Stick; over, Smother, Pop, Lock).

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Primary sclerosing cholangitis (PSC) is a risk factor for cholangiocarcinoma. When a child is diagnosed with both PSC and inflammatory bowel disease (IBD), evidence-based information on counseling families and risk management of developing cholangiocarcinoma is limited. In this case series (PubMed/collaborators), we included patients with PSC-IBD who developed cholangiocarcinoma and contacted authors to determine an event curve specifying the time between the second diagnosis (IBD or PSC) and a diagnosis of cholangiocarcinoma.

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Arsenic Exposure in Celiac Disease: The Hidden Cost of a Gluten-Free Diet.

Am J Gastroenterol

December 2024

Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, MassGeneral Hospital for Children, Harvard Medical School, Boston, Massachusetts, USA.

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Objectives: Massachusetts signed into law An Act Modernizing Tobacco Control (hereinafter, the Act) in 2019, which restricted retail sales of flavored tobacco products, including menthol cigarettes. This study assessed differences in advertising exposure to flavored tobacco products among adolescents in Massachusetts compared with adolescents in 4 neighboring states after passage of the Act.

Methods: We collected monthly cross-sectional survey data from April 2021 through August 2022 among a convenience sample of adolescents (aged 13-17 y) in Massachusetts and 4 control states: Connecticut, New Hampshire, Rhode Island, and Vermont.

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Rationale: There is increasing interest in establishing psychedelic research programs at academic medical centers. However, psychedelics are intensely psychoactive, carry considerable sociopolitical baggage, and most are Schedule I drugs, creating significant potential impediments to implementation. There is little formal guidance for investigators on navigating the complex on-the-ground obstacles associated with establishing psychedelic research programs.

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Feasibility Randomized Controlled Trial of the Toolkit for Optimal Recovery After Concussion: A Live Video Program to Prevent Persistent Concussion Symptoms in Young Adults With Anxiety.

Arch Phys Med Rehabil

November 2024

Center for Health Outcomes and Interdisciplinary Research, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Department of Psychiatry, Boston, Massachusetts.

Article Synopsis
  • The study aimed to evaluate the Toolkit for Optimal Recovery after Concussion (TOR-C) and its effectiveness in preventing continuous concussion symptoms in young adults with anxiety compared to an active control group (HE-C).
  • A total of 50 participants aged 18-35, who had suffered a concussion within the last 3-10 weeks and displayed anxiety, engaged in four 45-minute Zoom sessions focused on different interventions.
  • Results showed that both intervention groups met feasibility benchmarks and experienced notable improvements in various outcomes like concussion symptoms and anxiety levels, with the TOR-C group specifically showing greater progress in certain areas like mindfulness and all-or-nothing behavior.
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How Child Health Financing and Payment Mitigate and Perpetuate Structural Racism.

Acad Pediatr

October 2024

Department of Pediatrics (A Arauz Boudreau and JM Perrin), Harvard Medical School, Boston, Mass; Division of General Academic Pediatrics (A Arauz Boudreau and JM Perrin), MassGeneral Hospital for Children, Harvard Medical School, Boston.

Health financing for children and youth comes mainly from commercial sources (especially, a parent's employer-sponsored insurance) and public sources (especially, Medicaid and Children's Health Insurance Plan [CHIP]). These 2 sources serve populations that differ in race and ethnicity. This inherent segregation perpetuates a system of disparities in health and health care.

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Article Synopsis
  • A study investigated the link between maternal autoimmune diseases and the risk of hematological cancers in children, using data from Taiwan's National Health Insurance program.
  • Researchers compared 2,172 children with blood cancers to a control group of those without, analyzing maternal health records to assess the impact of autoimmune conditions.
  • Findings suggested that while overall risk increases slightly (odds ratio of 1.2), certain diseases like psoriatic arthritis and ankylosing spondylitis showed a higher adjusted risk for hematological malignancies in offspring.
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Clinical presentation and factors associated with gluten exposure in children with celiac disease.

J Pediatr Gastroenterol Nutr

October 2024

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Division of Gastroenterology, Hepatology and Nutrition, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Objectives: The prevalence of celiac disease (CeD) is increasing, yet it is still underdiagnosed, in part because of its heterogeneous presentation. Diagnostic criteria are evolving and management with strict adherence to a gluten-free diet is challenging for many. We aimed to characterize the clinical presentation of CeD among a large multicenter cohort of pediatric patients and to identify factors associated with gluten-free diet adherence.

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Objective: Prenatal protein malnutrition produces anatomical and functional changes in the developing brain that persist despite immediate postnatal nutritional rehabilitation. Brain networks of prenatally malnourished animals show diminished activation of prefrontal areas and an increased activation of hippocampal regions during an attentional task [1]. While a reduction in cell number has been documented in hippocampal subfield CA1, nothing is known about changes in neuron numbers in the prefrontal or parahippocampal cortices.

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Hypertension has largely been viewed as a disorder of adulthood. Historically, blood pressure (BP) was not routinely measured in children because hypertension was considered uncommon in childhood. It was not until the 1970s that it was apparent that in childhood BP levels were normally lower compared with those in adults, were related to age and growth, and that abnormal BP in children needed different definitions.

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Background: The prevalence of pediatric food allergies is increasing. Although pediatric residents are frontline providers for children with food allergies, little is known about pediatric residents' educational experiences and comfort with infant and toddler food allergy.

Methods: An anonymous online needs assessment survey was created and distributed to 64 residents in one residency program.

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Objective: To examine whether a personal history of migraines is associated with worse acute symptom burden after sport-related concussion (SRC).

Design: Retrospective cohort study.

Setting: National Collegiate Athletic Association Division III collegiate programs.

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Child Protection System Removal and Short-Interval Births Among Individuals With Prenatal Substance Use.

Obstet Gynecol

May 2024

Gillings School of Global Public Health, the Department of Obstetrics & Gynecology, and the School of Social Work, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; MassGeneral Hospital for Children, Harvard Medical School, Boston, Massachusetts; and Friends Research Institute, Baltimore, Maryland.

Child protection systems often intervene after substance-exposed births but are not designed to address the postpartum needs of the delivering parent. In this retrospective cohort study, we aimed to estimate the association between early child protection system removal and high-risk subsequent birth trajectories among a cohort of mothers with substance-exposed births in California. Of 6,893 births in 2015 with documented prenatal drug and alcohol exposure, 20.

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Treatment of chronic symptoms following mild traumatic brain injury with transcranial LED: a sham run-in pilot study of photobiomodulation therapy.

Brain Inj

May 2024

Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Schoen Adams Research Institute at Spaulding Rehabilitation, Massachusetts General Hospital, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.

Primary Objective: We evaluated whether photobiomodulation with red/near infrared light applied transcranially via light emitting diodes (LED) was associated with reduced symptoms and improved cognitive functioning in patients with chronic symptoms following mild traumatic brain injury.

Research Design: Participants (3 men, 6 women; 22-61 years-old) underwent a 6-week intervention involving 18 40-minute transcranial LED treatment sessions.

Methods And Procedures: Reliable change indices were calculated for 10 neuropsychological test scores and 3 self-report questionnaires of subjective cognition, post-concussion symptoms, and depression at baseline and following treatment.

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Introduction: Early childhood malnutrition affects 200+ million children under 5 years of age worldwide and is associated with persistent cognitive, behavioral and psychiatric impairments in adulthood. However, very few studies have investigated the long-term effects of childhood protein-energy malnutrition (PEM) on brain function using a functional hemodynamic brain imaging technique.

Objective And Methods: This study aims to investigate functional brain network alterations using near infrared spectroscopy (NIRS) in adults, aged 45-51 years, from the Barbados Nutrition Study (BNS) who suffered from a single episode of malnutrition restricted to their first year of life (n = 26) and controls (n = 29).

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Non-Host Factors Influencing Onset and Severity of Celiac Disease.

Gastroenterology

June 2024

Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

Celiac disease (CeD) is a chronic autoimmune condition driven by gluten ingestion in genetically predisposed individuals, resulting in inflammatory lesions in the proximal small intestine. Although the presence of specific HLA-linked haplotypes and gluten consumption are necessary for disease development, they alone do not account for the variable onset of CeD in susceptible individuals. This review explores the multifaceted role of non-host factors in CeD development, including dietary and microbial influences.

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Background: Clinicians must learn to care for patients from different cultures. They must also work in teams for optimal outcomes. Few studies have analysed the intersection of cross-cultural care and interprofessional education.

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Zonulin as a Biomarker for the Development of Celiac Disease.

Pediatrics

January 2024

Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, MassGeneral Hospital for Children, Harvard Medical School, Boston, Massachusetts.

Objectives: Increased intestinal permeability seems to be a key factor in the pathogenesis of autoimmune diseases, including celiac disease (CeD). However, it is unknown whether increased permeability precedes CeD onset. This study's objective was to determine whether intestinal permeability is altered before celiac disease autoimmunity (CDA) in at-risk children.

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Resident burnout is at an all-time high. In response, the Accreditation Council for Graduate Medical Education (ACGME) developed the Back to Bedside grant for resident-led burnout interventions that increase the time residents spend with patients. We designed a resident-patient reading intervention, Giving Literal Thanks (GLT), intended to increase meaningful time residents spend with patients and thereby decrease burnout.

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Nutrition and risk of celiac disease - you are what you (wh)eat.

Am J Clin Nutr

December 2023

Division of Pediatric Gastroenterology and Nutrition, MassGeneral Hospital for Children, Harvard Medical School, Boston, MA, United States; Mucosal Immunology and Biology Research Center, MassGeneral Hospital for Children, Harvard Medical School, Boston, MA, United States; Harvard Medical School, Celiac Education and Research Program, Boston, MA, United States. Electronic address:

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A Qualitative Study of Barriers and Facilitators to Integrating Medications for Opioid Use Disorder and HIV Preexposure Prophylaxis for Adolescents and Young Adults.

J Addict Med

November 2023

From the Division of Adolescent Medicine, Department of General Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA (MCH, KD); Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (SW, ND); Division of Adolescent and Young Adult Medicine, MassGeneral Hospital for Children/Harvard Medical School, Boston, MA (SEH); and Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania (DM).

Article Synopsis
  • The study examines the intersection of opioid use disorder (OUD) and HIV prevention among adolescents and young adults, highlighting a lack of focus on preexposure prophylaxis (PrEP) for this group despite rising healthcare options.
  • Healthcare providers identified barriers to prescribing PrEP, including stigma, provider perceptions, and systemic limitations, while patient-initiated requests and supportive staff were seen as facilitators for increasing PrEP use.
  • The findings suggest that healthcare discussions regarding HIV prevention for young patients on OUD treatments are infrequent, indicating a need for improved integration of PrEP services into OUD care.
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