922 results match your criteria: "MassGeneral Hospital[Affiliation]"

Down syndrome across the lifespan.

Am J Med Genet C Semin Med Genet

December 2023

MassGeneral Hospital Down Syndrome Program, Down Syndrome Research Program, Boston, Massachusetts, USA.

View Article and Find Full Text PDF

Background: Clinicians must learn to care for patients from different cultures. They must also work in teams for optimal outcomes. Few studies have analysed the intersection of cross-cultural care and interprofessional education.

View Article and Find Full Text PDF

Zonulin as a Biomarker for the Development of Celiac Disease.

Pediatrics

January 2024

Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, MassGeneral Hospital for Children, Harvard Medical School, Boston, Massachusetts.

Objectives: Increased intestinal permeability seems to be a key factor in the pathogenesis of autoimmune diseases, including celiac disease (CeD). However, it is unknown whether increased permeability precedes CeD onset. This study's objective was to determine whether intestinal permeability is altered before celiac disease autoimmunity (CDA) in at-risk children.

View Article and Find Full Text PDF

Resident burnout is at an all-time high. In response, the Accreditation Council for Graduate Medical Education (ACGME) developed the Back to Bedside grant for resident-led burnout interventions that increase the time residents spend with patients. We designed a resident-patient reading intervention, Giving Literal Thanks (GLT), intended to increase meaningful time residents spend with patients and thereby decrease burnout.

View Article and Find Full Text PDF

Nutrition and risk of celiac disease - you are what you (wh)eat.

Am J Clin Nutr

December 2023

Division of Pediatric Gastroenterology and Nutrition, MassGeneral Hospital for Children, Harvard Medical School, Boston, MA, United States; Mucosal Immunology and Biology Research Center, MassGeneral Hospital for Children, Harvard Medical School, Boston, MA, United States; Harvard Medical School, Celiac Education and Research Program, Boston, MA, United States. Electronic address:

View Article and Find Full Text PDF

A Qualitative Study of Barriers and Facilitators to Integrating Medications for Opioid Use Disorder and HIV Preexposure Prophylaxis for Adolescents and Young Adults.

J Addict Med

November 2023

From the Division of Adolescent Medicine, Department of General Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA (MCH, KD); Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (SW, ND); Division of Adolescent and Young Adult Medicine, MassGeneral Hospital for Children/Harvard Medical School, Boston, MA (SEH); and Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania (DM).

Article Synopsis
  • The study examines the intersection of opioid use disorder (OUD) and HIV prevention among adolescents and young adults, highlighting a lack of focus on preexposure prophylaxis (PrEP) for this group despite rising healthcare options.
  • Healthcare providers identified barriers to prescribing PrEP, including stigma, provider perceptions, and systemic limitations, while patient-initiated requests and supportive staff were seen as facilitators for increasing PrEP use.
  • The findings suggest that healthcare discussions regarding HIV prevention for young patients on OUD treatments are infrequent, indicating a need for improved integration of PrEP services into OUD care.
View Article and Find Full Text PDF
Article Synopsis
  • Childhood obesity is a significant issue in the U.S., especially affecting low-income and minority communities, and has worsened due to the COVID-19 pandemic, highlighting the need for effective pediatric weight management interventions (PWMIs) like the Healthy Weight Clinic.
  • The study involved interviews with stakeholders from both pre-implementation sites in Mississippi and sites that have already implemented the PWMIs to identify factors that facilitate or hinder successful adoption and any necessary adaptations.
  • Key findings indicate that a positive learning environment, staff commitment to evidence-based practices, and awareness of social health drivers are crucial for the successful implementation of childhood obesity interventions in diverse communities.
View Article and Find Full Text PDF
Article Synopsis
  • Axenfeld-Rieger anomaly (ARA) is a complex ocular disorder often linked with various systemic issues, and while many cases are explained by genetic variants, about 30% remain unclear.
  • Researchers identified pathogenic variants in nine families with ARA or related conditions, highlighting genetic overlaps with Alagille syndrome and other disorders like cognitive impairment, skeletal anomalies, and dental defects.
  • The study suggests using broad genetic testing, like exome sequencing, as a second-tier diagnostic option for ARA/ARS patients, especially when initial tests yield normal results, to improve clinical management.
View Article and Find Full Text PDF

Racial and Ethnic Disparities in Metabolic Bone Disease.

Endocrinol Metab Clin North Am

December 2023

Department of Medicine, Endocrine Division, Massachusetts General Hospital and Harvard Medical School, 50 Blossom Street, Thier 1051, Boston, MA 02114, USA. Electronic address:

Racial and ethnic disparities exist in the prevalence and management of osteoporosis, metastatic cancer, and sickle cell disease. Despite being the most common metabolic bone disease, osteoporosis remains underscreened and undertreated among Black women. Skeletal-related events in metastatic cancer include bone pain, pathologic fractures, and spinal cord compression.

View Article and Find Full Text PDF

Food Pantry Referral and Utilization in a Pediatric Primary Care Clinic.

Am J Prev Med

March 2024

Division of Health Services Research, Department of Pediatrics, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts.

Introduction: This study aimed to characterize progression from screening for food insecurity risk to on-site food pantry referral to food pantry utilization in pediatric primary care.

Methods: This retrospective study included 14,280 patients aged 0-21 years with ≥1 pediatric primary care visit from March 2018 to February 2020. Analyses were conducted in 2020-2022 using multivariable regression to examine patient-level demographic, clinical, and socioeconomic characteristics and systems-related factors associated with progression from screening positive for food insecurity risk to food pantry referral to completing ≥1 food pantry visit.

View Article and Find Full Text PDF

Objective: This study compares the complementary information from semi-quantitative EEG (sqEEG) and spectral quantitative EEG (spectral-qEEG) to detect the life-long effects of early childhood malnutrition on the brain.

Methods: Resting-state EEGs ( = 202) from the Barbados Nutrition Study (BNS) were used to examine the effects of protein-energy malnutrition (PEM) on childhood and middle adulthood outcomes. sqEEG analysis was performed on Grand Total EEG (GTE) protocol, and a single latent variable, the semi-quantitative Neurophysiological State (sqNPS) was extracted.

View Article and Find Full Text PDF

Cholera caused by O139 emerged in the early 1990s and spread rapidly to 11 Asian countries before receding for unclear reasons. Protection against cholera is serogroup-specific, which is defined by the O-specific polysaccharide (OSP) component of lipopolysaccharide (LPS). O139 also expresses the OSP-capsule.

View Article and Find Full Text PDF

A Clinician's Guide to Gluten Challenge.

J Pediatr Gastroenterol Nutr

December 2023

the Celiac Research Program, Harvard Medical School, Boston, MA.

Gluten challenge is an essential clinical tool that involves reintroducing or increasing the amount of gluten in the diet to facilitate diagnostic testing in celiac disease (CD). Nevertheless, there is no consensus regarding the applications of gluten timing, dosing, and duration in children. This review aims to summarize the current evidence, discuss practical considerations, and proposes a clinical algorithm to help guide testing in pediatric patients.

View Article and Find Full Text PDF

Objectives: This study examines the prevalence of detectable gluten immunogenic peptides (GIPs) as a proxy for gluten exposure in children with celiac disease on a gluten-free diet in the United States, as estimated by gluten breakdown products excreted in urine and stool.

Methods: Urine and stool samples were collected in 3 settings (home, gastroenterology clinic, and endoscopy) for pediatric participants (ages 6-21 years old) across 2 medical centers. Commercial ELISA assays were used to quantify the GIPs in each sample.

View Article and Find Full Text PDF

Introduction: Some ultra-high exposure boxers from the 20th century suffered from neurological problems characterized by slurred speech, personality changes (e.g., childishness or aggressiveness), and frank gait and coordination problems, with some noted to have progressive Parkinsonian-like signs.

View Article and Find Full Text PDF

Purpose: Young adults with anxiety are vulnerable to developing persistent symptoms following concussions. In order to develop psychosocial interventions to prevent persistent post-concussion symptoms, we need to understand patients' 1) experiences with treatments offered by health care providers; 2) experiences with attempted concussion management strategies; and 3) needs after their injury.

Methods: We conducted in-depth interviews with 17 young adults with recent (≤ 10 weeks) concussions who have at least mild anxiety (Generalized Anxiety Disorder Assessment-7 ≥ 5).

View Article and Find Full Text PDF

Background: Compared to single substance use, adolescents' use of multiple substances is associated with more severe dependence, cessation outcomes, and health risks. This study examined correlates of use and co-use of e-cigarettes, combusted tobacco, and cannabis among high school-aged (9th-12th grade, approximately aged 14-18) adolescents.

Methods: We analyzed the 2019 Massachusetts Youth Health Survey (MYHS) data to calculate the weighted means of any past 30-day sole-use of e-cigarettes, sole-use of combusted tobacco, sole-use of cannabis, dual-use of two of the above substances, and poly-use of all three substances.

View Article and Find Full Text PDF

Whether social determinants of health are associated with clinical outcome following concussion among adolescents is not well established. The present study examined whether neighborhood-level determinants are associated with clinical recovery time following concussion in adolescents. Participants included adolescent student athletes ( = 130; mean age = 16.

View Article and Find Full Text PDF

Importance: Retaining female physicians in the academic health care workforce is necessary to serve the needs of sociodemographically diverse patient populations.

Objective: To investigate differences in rates of leaving academia between male and female physicians.

Design, Setting, And Participants: This cohort study used Care Compare data from the Centers for Medicare & Medicaid Services for all physicians who billed Medicare from teaching hospitals from March 2014 to December 2019, excluding physicians who retired during the study period.

View Article and Find Full Text PDF

Introduction: This systematic review examined whether race or ethnicity are associated with clinical outcomes (e.g., time to return to school/sports, symptom duration, vestibular deficits, and neurocognitive functioning) following sport-related concussion among child, adolescent, or college-aged student athletes.

View Article and Find Full Text PDF

Background: The risk factors for unplanned emergency department (ED) visits and readmission after injury and the impact of these unplanned visits on long-term outcomes are not well understood. We aim to: 1) describe the incidence of and risk factors for injury-related ED visits and unplanned readmissions following injury and, 2) explore the relationship between these unplanned visits and mental and physical health outcomes 6-12 months post-injury.

Methods: Trauma patients with moderate-to-severe injury admitted to one of three Level-I trauma centers were asked to complete a phone survey to assess mental and physical health outcomes at 6-12 months.

View Article and Find Full Text PDF

Objective: The tackle is the most injurious event in rugby league and carries the greatest risk of concussion. This study aims to replicate previous research conducted in professional men's rugby league by examining the association between selected tackle characteristics and head impact events (HIEs) in women's professional rugby league.

Methods: We reviewed and coded 83 tackles resulting in an HIE and every tackle (6,318 tackles) that did not result in an HIE for three seasons (2018-2020) of the National Rugby League Women's (NRLW) competition.

View Article and Find Full Text PDF
Article Synopsis
  • The 6th International Conference on Concussion in Sport took place in Amsterdam from October 27-30, 2022, leading to a new consensus statement and updates on concussion protocols.
  • In preparation, author groups conducted extensive systematic reviews over 3½ years on key concussion-related topics, informing the conference discussions and outcomes.
  • The conference introduced revised tools like CRT6 and SCAT6, emphasized the importance of the para athlete's perspective, and highlighted gaps in research concerning concussion prevention and long-term effects.
View Article and Find Full Text PDF

The purpose of this paper is to summarise the consensus methodology that was used to inform the International Consensus Statement on Concussion in Sport (Amsterdam 2022). Building on a Delphi process to inform the questions and outcomes from the 5th International Conference on Concussion in Sport, the Scientific Committee identified key questions, the answers to which would help encapsulate the current science in sport-related concussion and help guide clinical practice. Over 3½ years, delayed by 2 years due to the pandemic, author groups conducted systematic reviews on each selected topic.

View Article and Find Full Text PDF