Laryngopharyngeal Reflux and Upper Airway Obstruction Patterns in Nonobese Sleep Apnea Patients.

Objectives: The study aims to investigate the relationship between the presence of laryngopharyngeal reflux (LPR) and obstruction levels identified during drug-induced sleep endoscopy (DISE) in obstructive sleep apnea (OSA) among nonobese patients.

Methods: We conducted a prospective study of 105 adult patients diagnosed with OSA who underwent DISE using propofol sedation from 2019 to 2024 at a tertiary hospital. To control for the confounding impact of obesity on LPR, the study selectively enrolled individuals presenting a body mass index within the normal range.

Molecular docking-guided in-depth investigation of the biological activities and phytochemical and mineral profiles of endemic Phlomis capitata.

Background: Phlomis capitata is an endemic species of flowering aromatic and medicinal plant in the family Lamiaceae, native to regions of the Mediterranean and nearby areas. Understanding the chemical compounds present in P. capitata can reveal potential medicinal properties.

Direct analysis and identification of the intestinal microflora of shrimps for their geographical traceability mass spectrometry and bacterial library searching.

The expansion of the seafood market has led to an increased probability of food fraud. The development of rapid and reliable traceability methods for aquatic food products is of utmost importance. In this study, direct analysis and identification of the intestinal microbiota of aquatic foods were conducted.

Scaling of shoot and root respiration of woody and herbaceous plants.

Woody and herbaceous plants are the main components of global terrestrial ecosystems, and their growth, adaptation and survival depend largely on the metabolism of shoots and roots. Therefore, understanding size-scaling of metabolic rates in woody and herbaceous plants, and in shoots and roots, is a fundamental issue in ecology. However, few empirical studies have examined metabolic scaling exponents across a wide range of plant sizes.

The effectiveness of exercise-based interventions on muscle mass, muscle strength, functional performance, aerobic capacity, and health-related quality of life in adults with malignant lymphoma undergoing chemotherapy: a systematic review of randomized controlled trials.

Purpose: This study aims to identify and summarize evidence on the effectiveness of exercise-based interventions on muscle mass, muscle strength, functional performance, aerobic capacity, health-related quality of life (HRQoL), feasibility of the interventions, in patients with malignant lymphoma undergoing chemotherapy.

Methods: A systematic search was conducted in six electronic databases and trials registers on November 15, 2023. Peer-reviewed randomized controlled trials (RCTs) comparing exercise intervention with controls/usual care in adults (≥18 years) diagnosed with Hodgkin's lymphoma and non-Hodgkin's lymphoma undergoing chemotherapy were considered for inclusion.

Improving the Long-term Enantioselectivity of a Silicon-Carbon Bond-Forming Enzyme.

Enantioselectivity is a key advantage of enzymatic catalysis. Understanding the most important factors influencing enantioselectivity necessitates thorough investigation for each specific enzyme. In this study, we explore various approaches to optimize reaction conditions for organosilicon production using an immobilized Cytochrome C recently tailored via directed evolution.

Behavioral Cetology in the 19th Century: Thomas Beale, Henry Cheever, Thomas Southwell and Their Role in Awakening a Cetacean Protection Consciousness.

Although naturalists have devoted attention to cetaceans since Antiquity, it was only in the 19th century that cetology underwent a true explosion. Three key cetological works of this period are The Natural History of the Sperm Whale (1839) by Thomas Beale, The Whaleman's Adventures in the Southern Ocean (1850) by Henry Cheever and The Seals and Whales of the British Seas (1881) by Thomas Southwell. Importantly, these three works did not only represent fundamental compendia of scientific knowledge of cetaceans, but also had a crucial role in awakening a cetacean protection consciousness.

Parent-Reported Feeding Practices Associated With Children's Observed Willingness-to-Try-New-Foods in Childcare.

Feeding behaviours are established early in life, with lifelong influences on children's appetite, growth and health, emphasizing the importance of understanding how parent-child feeding interactions relate to children's eating and growth patterns. The objective was to examine reciprocity between parent-reported feeding practices and children's observed willingness-to-try-new-foods in childcare settings without parental presence, thereby assessing independence from context and parental influence. The sample included parent-child dyads (n = 436) recruited from 51 childcare centres across 10 counties.

Curative Parathyroidectomy in Primary Hyperparathyroidism Improves Both Systolic and Diastolic Cardiac Dysfunction: A Six-Month Follow-Up Study at a Tertiary Care Hospital.

Background: Primary hyperparathyroidism (PHPT) is associated with hypertension, left ventricular hypertrophy, and myocardial and valvular calcifications, leading to increased mortality rates. While the association between PHPT and diastolic dysfunction has been well-documented, data on systolic dysfunction and its reversal after curative parathyroidectomy (PTX) remains limited.

Purpose: To evaluate the effect of PTX on cardiovascular parameters, especially systolic dysfunction, in PHPT patients using conventional and speckle-tracking echocardiography (STE).

Adverse Cardiovascular Risk Profile and Increased Diurnal Salivary Cortisol in Girls With Turner Syndrome: An Exploratory Study.

Patients with Turner Syndrome (TS) and those exposed to high concentrations of glucocorticoids have a number of characteristics in common, including an increased risk of cardiovascular disease. Pediatric TS patients underwent studies of salivary cortisol (SC) and cortisone (SCn), body composition, continuous glucose monitoring, vascular function, and ambulatory blood pressure (BP). Biochemical indicators of cardiovascular risk were also measured.

Sarcopenia As a Predictor of Survival and Complications of Patients With Cirrhosis After Liver Transplantation: A Systematic Review and Meta-Analysis.

Introduction: This systematic review/meta-analysis evaluated the impact of sarcopenia in patients with cirrhosis before liver transplantation (LT) on outcomes after LT.

Methods: A systematic search was conducted in six medical databases until February 2022. The primary outcome was overall mortality after LT, while several secondary outcomes including liver graft survival and rejection, the need for transfusions, the length of the intensive care unit (ICU) and hospital stay, and surgical complications were evaluated.

Protocol for Oligonucleotides Characterization Using Hydrophilic Interaction Chromatography.

Oligonucleotides (ONs) are an increasingly popular category of molecules in the pharmaceutical landscape, particularly attractive for the treatment of genetic and rare diseases. However, analyzing these molecules presents significant challenges, due to their highly hydrophilic nature, multiple negative charges, and the presence of closely related impurities resulting from the complex solid-phase synthesis process. Ion pairing reverse-phase liquid chromatography (IP-RPLC) is the preferred technique for ONs analysis but is not ideal for mass spectrometry (MS) coupling.

Use of Resonant Acoustic Fields as Atmospheric-Pressure Ion Gates.

Ion optics are crucial for spectrometric methods such as mass spectrometry (MS) and ion mobility spectrometry (IMS). Among the wide selection of ion optics, temporal ion gates are of particular importance for time-of-flight MS (TOF-MS) and drift-tube IMS. Commonly implemented as electrostatic ion gates, these optics offer a rapid, efficient means to block ion beams and form discrete ion packets for subsequent analysis.

Plant-based eating pattern and psychological symptoms: a cross-sectional survey among patients with migraine.

Objectives: The present study evaluated the association between plant-based diet index (PDI) and psychological symptoms, including depressive symptoms, stress, and anxiety among Iranian women diagnosed with migraine headaches.

Methods: A cross-sectional study was conducted on 262 patients with migraine (aged 20-50 years; body mass index, 18.5-30 kg/m²).

Mechanism of Exogenous Melatonin to Alleviate the Fermentation Performance of Saccharomyces cerevisiae Under Copper Stress.

Melatonin is involved in biological adverse stress response and enhances the ability of yeast to adapt to adverse conditions. This study investigated the mechanism of exogenous melatonin addition to Saccharomyces cerevisiae (S. cerevisiae) under copper stress.

Evaluating the Effectiveness of a Novel Pongamia pinnata Derived Herbal Mouth-Dissolving Film for Treating Oral Disorders and Evaluating Its Anticancer Properties.

The present study aimed to optimize a mouth-dissolving film (MDF) made from Pongamia pinnata stem bark extract to increase patient compliance and accelerate oral disease therapy. Several stem bark extracts were prepared, and karanjin was used as an herbal marker for the extracts. The ethanolic extract showed the maximum yield (12.

In-vitro susceptibility of pathogenic and intermediate Leptospira species towards antibiotics and herb extracts.

Leptospirosis is a severe and potentially fatal re-emerging zoonotic and waterborne disease caused by pathogenic and intermediate species of Leptospira. Given the high global rates of morbidity and mortality associated with this disease, there is an urgent need to explore alternative therapeutic agents to enhance treatment options. This study investigates the anti-leptospiral efficacy of several common antibiotics-penicillin G, doxycycline, ampicillin, amoxicillin, cefotaxime, chloramphenicol, and erythromycin, as well as extracts from local herbs, Hydnophytum formicarum Jack and Boesenbergia stenophylla, against pathogenic and intermediate Leptospira strains.

Atmospheric-level carbon dioxide gas sensing using low-loss mid-IR silicon waveguides.

Interest in carbon dioxide (CO) sensors is growing rapidly due to the increasing awareness of the link between air quality and health. Indoor, high CO levels signal poor ventilation, and outdoor the burning of fossil fuels and its associated pollution. CO gas sensors based on integrated optical waveguides are a promising solution due to their excellent gas sensing selectivity, compact size, and potential for mass manufacturing large volumes at low cost.

Design of a large imaging plane wide-band zoom adapter optical system for endoscopes.

This paper presents a design of a large imaging plane wide-band zoom optical system, by analyzing the Gaussian principle of the mechanically compensated zoom system, the initial structural parameters are determined. The optimized system has a zoom range of 18-35.5 mm and distortion is less than 2%.

Thermodynamic coupling analysis of precision molding process for chalcogenide glass microlens array under multiple loads.

Precision glass molding (PGM) technology, as an efficient and straightforward method for producing glass lenses, has been widely applied in the mass production of aspheric glass lenses. However, molding complex surfaces such as free-form and array surfaces is still in its infancy. To reveal the variations of temperature and stress of microlens array (MLA) optical elements during the molding process, a simulation model was established using the finite element method (FEM), and the heating and forming stages of a chalcogenide glass MLA optical element were studied.

Bricks-on-pedestals silicon optomechanical cavity: a mass sensor for nanoparticles detection.

Optomechanical cavities can be used as highly sensitive mass sensors actuated by an optical field. In this work, we introduce and numerically demonstrate a new design for an optomechanical cavity consisting of a series of asymmetrically distributed rectangular silicon nanobricks, with each brick acting as an independent mechanical resonator but all coupled to the same optical field. Each silicon brick is placed on top of a thin silica pillar that ensures mechanical support whilst providing enough acoustic isolation between the individual mechanical resonances - at GHz frequencies - of each brick.

Laser-induced hole coherence in 2D antiferromagnet MPS through spatial self-phase modulation.

Transition metal phosphorus sulfides (MPS), a family of two-dimensional magnetic materials with a van der Waals structure, exhibit promising applications in nonlinear optical devices. The emergence of carrier coherence in MPS is a fascinating topic in coherently controlling the nonlinear effect (or other novel phenomena). Herein, we systematically investigated the third-order nonlinear optical responses of MPS (M = Ni, Fe, Mn) flake suspensions based on spatial self-phase modulation (SSPM) effect.

High combiner efficiency and self-aligned compact double-sided diffractive waveguide based on linear surface relief gratings.

A diffractive waveguide based on surface relief gratings demonstrates significant potential for augmented reality owing to its ultra-thin and lightweight design, as well as its feasibility for mass production using nanoimprint technology. However, traditional waveguides suffer from low combiner efficiency. To address this issue, we propose what we believe to be a novel double-sided surface relief grating waveguide (abbreviated as double-sided waveguide) with a high combiner efficiency, which comprises a double-sided in-coupler, two single-sided turners, and a double-sided out-coupler.

Cognitive Benefits of Open-Skill Sports in Childhood: Evidence from the ABCD Study.

Background: Sports participation in childhood is known to benefit physical health, but its impact on cognitive development, particularly comparing open-skill and closed-skill sports, is less understood.

Methods: This study analyzed baseline data from the Adolescent Brain Cognitive Development (ABCD) study, comprising 11,869 children aged 9-10 years. Participants were categorized into open-skill sports group (OSG), closed-skill sports group (CSG), and non-sport group (NSG).