Stimuli-responsive carrageenan-based biomaterials for biomedical applications.

Carrageenan-based biomaterials have attracted considerable attention in recent years due to their unique biological properties, including their biodegradability, compatibility, and lack of adverse effects. These biomaterials exhibit a variety of beneficial properties, such as antiviral, antitumor, and immunomodulatory effects, which set them apart from other polysaccharides. Stimuli-responsive carrageenan-based biomaterials have attracted particular attention due to their unique properties, such as reducing systemic toxicity and controlling drug release.

Expression of miR-155 and CEA and VEGF Proteins as Diagnostic Markers in Early Stages of Non-Small Cell Lung Cancer in Peripheral Blood.

Background: Cancer is a disease caused by manifestation and abnormal gene expression. Many of the genes that inhibit cancer by the microRNAs. The aim of this study was to investigate the Expression of miR155 gene and CEA and VEGF proteins as Diagnostic Markers in Early Stages of Non-Small Cell Lung Cancer (NSCLC).

Evaluating the impact of Benson's relaxation technique on anxiety and delirium among coronary artery bypass graft surgery patients.

Background: Anxiety and delirium are prevalent complications in cardiac patients undergoing invasive procedures like coronary artery bypass surgery, with untreated symptoms potentially leading to enduring physical and psychological consequences. Benson's relaxation technique, a method of attention focusing, has demonstrated efficacy in alleviating various symptoms, although findings are conflicting. Thus, this study aimed to assess the influence of Benson's relaxation on anxiety and delirium severity in open-heart surgery candidates.

The importance of paying attention to the role of lipid-lowering drugs in controlling dengue virus infection.

The Flaviviridae family includes the dengue virus (DENV). About half of the world's population is in danger because of the estimated 390 million infections and 96 million symptomatic cases that occur each year. An effective treatment for dengue fever (DF) does not yet exist.

A state-of-the-art review of the recent advances in drug delivery systems for different therapeutic agents in periodontitis.

Periodontitis (PD) is a chronic gum illness that may be hard to cure for a number of reasons, including the fact that no one knows what causes it, the side effects of anti-microbial treatment, and how various kinds of bacteria interact with one another. As a result, novel therapeutic approaches for PD treatment must be developed. Additionally, supplementary antibacterial regimens, including local and systemic medication administration of chemical agents, are necessary for deep pockets to assist with mechanical debridement of tooth surfaces.

Predictive properties of novel anthropometric and biochemical indexes for prediction of cardiovascular risk.

Objective: Our aim was to examine the correlation between CVDs and various anthropometric and biochemical indices in the Iranian population.

Methods: 9704 healthy individuals without CVD aged 35-65 were enrolled in our study. The anthropometric indices including Body Adiposity Index (BAI), Abdominal Volume Index (AVI), Body Roundness Index (BRI), Waist to Hip Ratio (WHR), Weight-adjusted Waist Index (WWI), Conicity Index (C-Index), A Body Shape Index (ABSI), Waist to Height Ratio (WHtR), Body Surface Area (BSA), Body Mass Index (BMI), Lipid Accumulation Product (LAP) and Visceral Adiposity Index (VAI) were calculated.

Immunomodulatory features of MSC-derived exosomes decorated with DC-specific aptamer for improving sublingual immunotherapy in allergic mouse model.

Introduction: Sublingual immunotherapy (SLIT) is an effective and injection-free route for allergen-specific immunotherapy (AIT). Mesenchymal stromal/stem cell (MSC)-derived exosomes (Exo) has been identified as a novel delivery platform with immunomodulatory capacities. In addition, targeting agents such as aptamers (Apt) have been extensively used for specific delivery approaches such as direct delivery of allergen formulations to dendritic cells (DC) to improve the efficacy of specific immunotherapy.

Manipulated mesenchymal stem cell therapy in the treatment of Parkinson's disease.

Mesenchymal stem cell (MSC) therapy has been considered a promising approach for the treatment of Parkinson's disease (PD) for several years. PD is a globally prevalent neurodegenerative disease characterized by the accumulation of Lewy bodies and the loss of dopaminergic neurons, leading to severe motor and non-motor complications in patients. As current treatments are unable to halt the progression of neuronal loss and dopamine degradation, MSC therapy has emerged as a highly promising strategy for PD treatment.

Effect of statins on arterial wall inflammation as assessed by 18F-FDG PET CT: an updated systematic review and meta-analysis.

Background: Pathogenesis of atherosclerosis is largely mediated by inflammatory process. Statins are lipid-lowering drugs which also have anti-inflammatory effects. 18 fluorine radiolabeled fluorodeoxyglucose (18 F-FDG) positron emission tomography-computed tomography (PET-CT) is considered to be a good indicator of arterial wall inflammation.

The relationship of macular vessel density and foveal avascular zone with pulse wave velocity and central blood pressure in healthy adults: Persian cohort study.

Background: To evaluate the correlation of macular vessel density (VD) and foveal avascular zone (FAZ) parameters measured on optical coherence tomography angiography (OCTA) with systemic arterial stiffness using pulse wave velocity (PWV), pulse wave analysis, arterial age, and central blood pressure (CBP) measurements in healthy subjects.

Methods: In a comparative, cross-sectional, observational study, healthy adults who participated in the PERSIAN Cohort study at Mashhad University of Medical Sciences were included in this study. The study involved using a spectral domain OCTA device to obtain 3 × 3 and 6 × 6 mm scans of the macular superficial capillary plexus (SCP) VD, deep capillary plexus (DCP) VD, and FAZ vascular analysis.

Regulatory effects of statins on CCL2/CCR2 axis in cardiovascular diseases: new insight into pleiotropic effects of statins.

Background: HMG-CoA reductase inhibitors are well-known medications in the treatment of cardiovascular disorders due to their pleiotropic and lipid-lowering properties. Herein, we reviewed the effects of statins on the CCL2/CCR2 axis.

Method: Scopus and Pubmed databases were systematically searched using the following keywords:" Hydroxymethylglutaryl CoA Reductase Inhibitors"," HMG-CoA Reductase Inhibitors"," Statins", "CCL2, Chemokine", "Monocyte Chemoattractant Protein-1" and "Chemokine (C-C Motif) Ligand 2".

Challenges and solutions in implementing electronic prescribing in Iran's health system: a qualitative study.

Background: The use of electronic prescribing is recognized as a strategic tool for improving healthcare. Given the nationwide implementation of electronic prescribing systems initiated in 2020, this study aims to explore the challenges and solutions for implementing electronic prescribing in Iran's health system as a developing country.

Methods: This qualitative study was conducted through interviews with physicians, pharmacy staff, and electronic prescribing representatives in 2023.