Trends in the Epidemiology of Deep Vein Thrombosis and Pulmonary Embolism in Patients Undergoing Surgery.

Objective This study aims to utilize the TriNetX database, a comprehensive global network, to improve our understanding of the frequency, demographic factors, and related comorbidities of surgical patients who develop venous thromboembolism (VTEs) events. Methods The global collaborative network in TriNetX was queried for all cases from January 1, 2017, through December 31, 2023. International Classification for Disease (ICD) diagnosis codes were used to define patient cohorts with deep vein thrombosis (DVT) of the upper or lower extremity or pulmonary embolism (PE).

Investigating the Impact of Sumac Capsules on Postpartum Bleeding among Women at Risk of Bleeding: a three-blind randomized clinical trial.

Objectives: Postpartum hemorrhage is a leading cause of maternal mortality worldwide. Emerging evidence suggests that the sumac plant possesses astringent and anti-inflammatory properties that may help reduce menstrual bleeding. Therefore, this study aimed to determine the effect of sumac capsules on postpartum bleeding among women at risk of excessive bleeding.

Recent progress in prompt molecular detection of liquid biopsy using Cas enzymes: innovative approaches for cancer diagnosis and analysis.

Creating fast, non-invasive, precise, and specific diagnostic tests is crucial for enhancing cancer treatment outcomes. Among diagnostic methods, those relying on nucleic acid detection are highly sensitive and specific. Recent developments in diagnostic technologies, particularly those leveraging Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR), are revolutionizing cancer detection, providing accurate and timely results.

Development of risk models for early detection and prediction of chronic kidney disease in clinical settings.

Chronic kidney disease (CKD) imposes a high burden with high mortality and morbidity rates. Early detection of CKD is imperative in preventing the adverse outcomes attributed to the later stages. Therefore, this study aims to utilize machine learning techniques to predict CKD at early stages.

Educational Intervention and Menopausal Adapting: A Randomized Controlled Trial.

Background And Aims: Menopause is a multifaceted condition with several problems. Educational interventions regarding self-care and limiting exposure to menopausal warning indicators can help to minimize problems. As a result, the study aimed to investigate the influence of educational intervention on variables influencing menopausal adaptation.

Seroprevalence of in a population of 15 to 35 years old in Mashhad.

Background And Objectives: is a bacterium involved in gastrointestinal disorders with a high prevalence in Iran. We have determined the seroprevalence of in the young adult population of Mashhad city for the first time.

Materials And Methods: We carried out a cross-sectional study on 933 individuals between the ages of 15 and 35 in Mashhad.

High prevalence of antimicrobial resistance genes in multidrug-resistant-ESBLs-producing post-COVID-19 pandemic.

Background And Objectives: is a common pathogen associated with healthcare-related infections. It is particularly notable for its ability to develop resistance to multiple antibiotics, making treatment challenging. During the COVID-19 pandemic, increased antibiotic use to manage critically ill patients was contributed to the rise of multidrug-resistant .

Androgen deprivation therapy use and the risk of heart failure in patients with prostate cancer: a systematic review and meta-analysis.

Background & Aim: We aimed in this study to investigate the relationship between Androgen Deprivation Therapy (ADT) use and the risk of heart failure in patients with prostate cancer. In this research, the negative or positive effects of ADT in the development of cardiovascular diseases or its exacerbation in people with prostate cancer have been investigated.

Materials And Methods: For this research, we reviewed articles from PubMed, Scopus, and Google Scholar databases until February 2024.

The effects of camel milk in systemic inflammation and oxidative stress of cigarette smoke-induced chronic obstructive pulmonary disease model in rat.

Background: The effects of camel milk in inflammation and systemic oxidative stress of cigarette smoke (CS)-induced chronic obstructive pulmonary disease (COPD) associated with small airway inflammation in rats were investigated.

Methods: 35 male Wistar rats were randomly divided into five groups: (a) control, (b) CS-exposed rats, c and (d) CS-exposed rats treated with the 4 and 8 mL/kg camel milk, and (e) CS-exposed rats treated with 1 mg/kg dexamethasone.

Results: Total and differential WBC counts, serum level of TNF- and malondialdehyde (MDA) level in serum and homogenized tissues of the heart, kidney, liver, and testicle were significantly increased, but catalase (CAT), superoxide dismutase (SOD) and thiol levels were significantly decreased in CS-exposed rats ( < 0.

Evaluating binding behavior of quercetin to human serum albumin and calf thymus DNA: Insights from molecular dynamics, spectroscopy, and apoptotic pathway regulation.

In this work, we sought to apprehend quercetin binding affinity and its interaction behavior in complex with human serum albumin (HSA) and calf thymus DNA (ctDNA) through multi spectroscopy and molecular dynamics and also evaluated its effects on colorectal cancer. The binding constants of ctDNA-quercetin and HSA-quercetin complexes at 298 K, which were calculated to be (2.67 ± 0.

The epidemiologic trend of multiple sclerosis in Razavi Khorasan Province, Iran in fifteen-year period.

Objective: Multiple sclerosis (MS) is a major global health problem as a growing debilitating disease and according to the Global Burden of Diseases study in 2016 has had a 40 % prevalence increase in Iran during the 3 previous decades; far more from the Global prevalence which only increased about 10 %. Razavi Khorasan is the second most populous province in Iran with over 6.5 million people and its MS status is not clear; therefore, this study aims to define the current epidemiologic trend of MS in Razavi Khorasan METHODS AND MATERIALS: We performed this cross-sectional, analytical study in Khorasan Razavi Multiple sclerosis Center during 2021-2023.

The G Protein-Coupled Receptor-Related Gene Signatures for Diagnosis and Prognosis in Glioblastoma: A Deep Learning Model Using RNA-Seq Data.

Background: Glioblastoma (GBM) is the most aggressive cancer in the central nervous system in glial cells. Finding novel biomarkers in GBM offers numerous advantages that can contribute to early detection, personalized treatment, improved patient outcomes, and advancements in cancer research and drug development. Integrating machine learning with RNAseq data in medicine holds significant potential for identifying novel biomarkers in various diseases, including cancer.

Assessment of meteorological factors and air pollution impact on cardiovascular mortality using random forest analysis 2017 to 2020.

Air pollution, a global health hazard, significantly impacts mortality, cardiovascular health, mental well-being, and overall human health. This study aimed to investigate the impact of air pollution and meteorological factors on cardiovascular mortality rates in Mashhad City, northeastern Iran in 2017-2020. We utilized a Random Forest (RF) model in this study.

Association between serum hypertriglyceridemia and hematological indices: data mining approaches.

Background: High triglyceride (TG) affects and is affected of other hematological factors. The determination of serum fasted triglycerides concentrations, as part of a lipid profile, is crucial key point in hematological factors and significantly affect various systemic diseases. This study was carried out to assess the potential relation between the concentration of TG and hematological factors.

Botox-A Induced Apoptosis and Suppressed Cell Proliferation in Fibroblasts Pre-Treated with Breast Cancer Exosomes.

Background: breast cancer-associated fibroblast (CAF) is linked to metastasis and is poor for breast cancer prognosis. Since Clostridium Toxin A (Botox-A) had represented a cytotoxic effect on fibroblasts, this study aims to assess Botox-A cytotoxicity in both normal fibroblasts and exosome-induced CAFs.

Material And Method: the serum exosomes of 40 BC patients and 30 healthy individuals were isolated and lncRNA H19 (lnch19) levels were assessed by qRT-PCR method.

Drug repositioning in castration-resistant prostate cancer using systems biology and computational drug design techniques.

Background And Objective: Castration-resistant prostate cancer (CRPC) is caused by resistance to androgen deprivation treatment and leads to the death of patients and there is almost no chance of survival. Therefore, finding a cure to overcome CRPC is challenging and important, but discovering a new drug is very time-consuming and expensive. To overcome these problems, we used Drug repositioning (drug repurposing) strategy in this study.

Effects of Tinospora cordifolia (giloy) on metabolic syndrome components: a mechanistic review.

Metabolic syndrome is a cluster of some conditions such as high blood sugar, high blood triglycerides, low HDL cholesterol, abdominal obesity, and high blood pressure. Introducing a drug or a food that manages the majority of these medical conditions is invaluable. Tinospora cordifolia, known as guduchi and giloy, is a medicinal herb in ayurvedic medicine that is used in the treatment of various diseased conditions and also as a food for the maintenance of health.

The Black Cloud of Endometriosis on different aspects of the Life of Women with Endometriosis: a qualitative study in Iran.

Aim: To explore the perception of the impact of endometriosis on various aspects in affected women with endometriosis.

Method: Data was gathered through in-depth and semi-structured individual interviews using open questions to comprehend women's experiences with endometriosis and their health-promoting lifestyle. The Conventional Qualitative Content Analysis approach was utilized, and sampling continued until data saturation.

Local Application of Honey for Postoperative Pain Management and Associated Outcomes Following Tonsillectomy in Children: A Systematic Review and Meta-Analysis.

Background: This study investigates the effect of locally applied honey on pain intensity, analgesia consumption, pain relief and nighttime awakenings in children following tonsillectomy, addressing conflicting evidence and the lack of differentiation between adult and paediatric populations in previous reviews.

Methods: A systematic search was conducted across multiple databases, including Cochrane Library, ClinicalTrials.gov, MEDLINE, Web of Science and Google Scholar.

A label-free DNAzyme-Mediated biosensor for fluorescent detection of Lead (II) ion.

Lead ion (Pb) is a common environmental contaminant, extremely toxic, persistent, and easily adsorbed, concentrated, and enriched by agricultural products. Ingestion of this ion can result in health problems for humans, including neurological disorders, heart disease, brain damage, and mental deficiency. In this research, a sensitive fluorescent biosensing method for detecting Pb was developed using DNAzyme as the target recognition element and SYBR Green (SG) fluorescent dye as the signal indicator.

The cardiometabolic benefits of okra-based treatment in prediabetes and diabetes: a systematic review and meta-analysis of randomized controlled trials.

Background: This systematic review and meta-analysis examine the effects of okra consumption on cardiometabolic risk factors in individuals with prediabetes and diabetes. Okra is a widely consumed vegetable with potential health benefits, and understanding its impact on metabolic parameters in these populations is important.

Methods: A comprehensive search of the literature was conducted up to May 2024 in PubMed/Medline, Scopus, and Web of Science to find relevant randomized clinical trials (RCTs) by using following keyword: ("okra" OR "okras" OR "") AND ("intervention" OR "controlled trial" OR "randomized" OR "randomized" OR "randomly" OR "clinical trial" OR "trial" OR "randomized controlled trial" OR "randomized clinical trial" OR "RCT" OR "blinded" OR "placebo" OR "Cross-Over" OR "parallel").

Promising role of peroxisome proliferator-activated receptors in respiratory disorders, a review.

Several studies indicate various pharmacological and therapeutic effects of peroxisome proliferator-activated receptors (PPARs) in different disorders. The current review describes the influences of PPARs on respiratory, allergic, and immunologic diseases. Various databases, including PubMed, Science Direct, and Scopus, were searched regarding the effect of PPARs on respiratory and allergic disorders from 1990 to 2024.

Crocin as a potential therapeutic agent for multiple sclerosis: insights from experimental autoimmune encephalomyelitis model in mice.

Objective: Multiple sclerosis (MS) is a prevalent autoimmune disorder characterized by neuroinflammation and demyelination in the central nervous system (CNS), leading to neurological dysfunction. Despite advances in treatment, there remains an unmet need for safe and effective therapies. Crocin, a bioactive constituent of saffron, has demonstrated anti-inflammatory and immunoregulatory properties in various disease models.

Chronic Obstructive Pulmonary Disease: The Role of Healthy and Unhealthy Dietary Patterns-A Comprehensive Review.

Chronic obstructive pulmonary disease (COPD) is a progressive and irreversible disease affecting many people worldwide. Recent evidence suggests that diet and lifestyle play a vital role in COPD progression. We aimed to provide a comprehensive review of the effect of healthy and unhealthy dietary patterns on preventing and treating COPD.