Clustering Iranian women according to their menopausal severity symptoms and exploring the factors associated with severe categories, using baseline category logit model.

Introduction: Many studies reported that the factors associated with the intensity of menopausal symptoms vary according to race, culture, and ethnicity. Different instruments, measure severe menopausal symptoms. The present study aims to classify Iranian women between 42 and 60 years according to the similarity of menopausal severity symptoms and then find the risk factors related to allocating in severe symptoms groups.

Evaluation of various root canal irrigation methods in primary teeth: a systematic review.

Background And Objectives: Although effective irrigation methods are crucial for pulpectomy in primary teeth (PT), no consensus exists on the best technique. This study guides clinicians in making evidence-based choices for irrigation techniques in PT.

Design: This study reviewed in vitro and in vivo research on PT using an extensive electronic search up to April 2024.

Effect of different surface treatments on shear bond strength of zirconia with various yttria contents.

Background: Achieving a stable bond with zirconia requires mechanical and chemical bonding methods. Information regarding the optimal treatment method for zirconia with varying yttrium content is scarce. This study evaluated the effect of different surface treatments on the shear bond strength of zirconia with various yttria contents.

NRF-Mediated Autophagy and UPR: Exploring New Avenues to Overcome Cancer Chemo-Resistance.

The development of chemo-resistance remains a significant hurdle in effective cancer therapy. NRF1 and NRF2, key regulators of redox homeostasis, play crucial roles in the cellular response to oxidative stress, with implications for both tumor growth and resistance to chemotherapy. This study delves into the dualistic role of NRF2, exploring its protective functions in normal cells and its paradoxical support of tumor survival and drug resistance in cancerous cells.

Stimuli-responsive carrageenan-based biomaterials for biomedical applications.

Carrageenan-based biomaterials have attracted considerable attention in recent years due to their unique biological properties, including their biodegradability, compatibility, and lack of adverse effects. These biomaterials exhibit a variety of beneficial properties, such as antiviral, antitumor, and immunomodulatory effects, which set them apart from other polysaccharides. Stimuli-responsive carrageenan-based biomaterials have attracted particular attention due to their unique properties such as reducing systemic toxicity and controlling drug release.

Topical formulation of Boswellia nano emulsion in psoriasis mouse model.

Organ-specific autoimmune inflammatory skin disease is called psoriasis. Pharmacological study indicates that Boswellia serrata (BS) gum resin is an active herbal element that has a significant role in the management of inflammatory diseases. Because BAs are steroidal (lipophilic), their systemic bioavailability is restricted.

Interactions of spontaneous abortion with gene and dietary carotenoids; a case-control study.

Spontaneous abortion (SA) is considered one of the most prevalent adverse outcomes of pregnancy. SA may occur due to genetic susceptibility and various maternal factors such as nutritional status. The aim of this study was to assess how dietary carotenoids and the gene are related to SA.

Examining the knowledge and attitude of nursing and midwifery students of medical sciences universities of Mazandaran province in the field of pain management and related factors in 2023.

Considering the importance of pain management and the complications of non-management by nurses, the present study was carried out with the aim of determining the knowledge and attitude of nursing and midwifery students of medical sciences universities of Mazandaran province in the field of pain management and related factors in 2022. The current research is a cross-sectional study (descriptive and analytical) that was conducted at Universities of Medical Sciences of Mazandaran Province. The sample size was calculated to be 207 people who were selected from nursing and midwifery students of the 5th to 8th semesters who were eligible to enter the study by systematic random sampling.

Expression of miR-155 and CEA and VEGF Proteins as Diagnostic Markers in Early Stages of Non-Small Cell Lung Cancer in Peripheral Blood.

Background: Cancer is a disease caused by manifestation and abnormal gene expression. Many of the genes that inhibit cancer by the microRNAs. The aim of this study was to investigate the Expression of miR155 gene and CEA and VEGF proteins as Diagnostic Markers in Early Stages of Non-Small Cell Lung Cancer (NSCLC).

Validation of GLIM criteria for hospital malnutrition diagnosis by comparison of three different anthropometric approaches to evaluate reduced muscle mass: a prospective cohort study.

Background And Aim: The Global Leadership Initiative on Malnutrition (GLIM) recently proposed a new malnutrition diagnostic tool known as the GLIM criteria. The GLIM criteria need confirmed validation before being widely used in each population or healthcare system. This study aimed to investigate the validation of the GLIM criteria for malnutrition diagnosis in hospitalized patients.

New horizons for promising influences of sulforaphane in the management of metabolic syndrome: a mechanistic review.

The disorder known as metabolic syndrome (MetS) represents a substantial threat to society since it is linked to a higher risk of heart disease, diabetes, stroke, and other health issues. Although there is no known cure for metabolic syndrome, lifestyle changes in diet and physical activity can help. Sulforaphane (SFN), a compound in cruciferous vegetables, has been recognized as a promising treatment for addressing metabolic syndrome.

Investigating the effect of echinacea extraction syrup on the outcomes of lower respiratory infections in patients with COVID-19: a randomized clinical trial study.

Introduction: Many COVID-19 patients experience mild to severe symptoms, including respiratory system involvement. Different treatment instructions have been suggested for patients with COVID-19. Echinacea has known antiviral effects.

Evaluating the impact of Benson's relaxation technique on anxiety and delirium among coronary artery bypass graft surgery patients.

Background: Anxiety and delirium are prevalent complications in cardiac patients undergoing invasive procedures like coronary artery bypass surgery, with untreated symptoms potentially leading to enduring physical and psychological consequences. Benson's relaxation technique, a method of attention focusing, has demonstrated efficacy in alleviating various symptoms, although findings are conflicting. Thus, this study aimed to assess the influence of Benson's relaxation on anxiety and delirium severity in open-heart surgery candidates.

The importance of paying attention to the role of lipid-lowering drugs in controlling dengue virus infection.

The Flaviviridae family includes the dengue virus (DENV). About half of the world's population is in danger because of the estimated 390 million infections and 96 million symptomatic cases that occur each year. An effective treatment for dengue fever (DF) does not yet exist.

A preclinical design approach for translation of biohybrid photosensitive nanoplatform for photodynamic therapy of breast cancer.

Translating photodynamic therapy research into practice with high efficacy should follow characterization and optimization steps in an integrated process. In this way, integration of molecular-based simulations with in vitro and in vivo studies to produce more accurate models with higher prediction precision is inevitable. This study reports on the development a two-phase approach to design and synthesize, and characterize novel hybrid nano-photosensitizers to target breast cancer using molecular docking, microfluidic-based testing and animal studies.

Prevalence and associated factors of mental health distress among hospitalized patients in general hospitals: a multi-center cross-sectional study in Iran.

Background: Understanding the prevalence of mental distress in hospitalized patients and identifying associated factors can help reduce the burden of mental disorders on their medical management and improve their quality of life. This study aimed to examine the prevalence of mental distress among hospitalized patients in general hospitals and assess its associated factors.

Methods: In this cross-sectional study, we evaluated the mental health status of inpatients in seven cities in Iran, using the General Health Questionnaire-12 (GHQ-12), with a total GHQ-12 score ≥ 4 or higher categorized as "mentally distressed.

Beyond antibiotics: mesenchymal stem cells and bacteriophages-new approaches to combat bacterial resistance in wound infections.

Wound management is a major global health problem. With the rising incidence of diabetic wounds, accidents, and other injuries, the demand for prompt wound treatment has become increasingly critical. Millions of people suffer from serious, large wounds resulting from major accidents, surgeries, and wars.

A state-of-the-art review of the recent advances in drug delivery systems for different therapeutic agents in periodontitis.

Periodontitis (PD) is a chronic gum illness that may be hard to cure for a number of reasons, including the fact that no one knows what causes it, the side effects of anti-microbial treatment, and how various kinds of bacteria interact with one another. As a result, novel therapeutic approaches for PD treatment must be developed. Additionally, supplementary antibacterial regimens, including local and systemic medication administration of chemical agents, are necessary for deep pockets to assist with mechanical debridement of tooth surfaces.

Urinary pentosidine as a potential biomarker of impaired bone health: a systematic review and meta-analysis.

Background: Urinary pentosidine, an advanced glycation end product (AGE), has been proposed as a potential biomarker for impaired bone health, especially in older adults and those with diabetes. This study aimed to systematically review and meta-analyze the association of urinary pentosidine with bone mineral density (BMD) and fracture risk.

Methods: A comprehensive search of Embase, PubMed, Scopus, and Web of Science databases was conducted and records were gathered from 1960 to February 2024.

Preparation of atorvastatin calcium-loaded liposomes using thin-film hydration and coaxial micromixing methods: A comparative study.

Development of techniques to produce nanoformulations in a controlled and reproducible manner is of great importance for research, clinical trials, and industrial scale-up. This research aimed to introduce a cost-effective micromixing approach for the nanoassembly of liposomes and compared with thin-film hydration (TFH) method. Numerical simulations and design of experiments (DOE) by response surface methodology (RSM) were used to evaluate the effects of input parameters on liposome properties, aiming to identify optimal conditions.