Insights into Voluntary Plasma Donation: A Study of Motivators and Obstacles.

Background: Plasma-derived medicines (PDMs) are essential for treating various disorders and require large volumes of human plasma. The debate on voluntary and compensated plasma donation continues, while WHO advocating for voluntary donations. This study examines factors influencing plasma donation, focusing on the effectiveness of voluntary donation and identifying key motivators and barriers.

Translation, Cross-Cultural Adaptation, Reliability, and Validity of the Persian Version of the Neck Outcome Score Questionnaire in Iranian Patients With Nonspecific Neck Pain.

Objective: The primary purpose of this study was to translate and culturally adapt the neck outcome score (NOOS) questionnaire into Persian language and investigate its reliability and validity.

Methods: The NOOS questionnaire was translated into Persian language and culturally adapted according to American Academy of Orthopaedic Surgeons guidelines. One hundred four patients with nonspecific neck pain were requested to complete the Persian version of the NOOS questionnaire, 36-item short form survey (SF-36), and neck disability index (NDI) questionnaire.

Health anxiety during a global pandemic: a comparison of medical and non-medical students in Mashhad, Iran.

Background: The COVID-19 pandemic has negatively impacted mental health worldwide, especially among healthcare professionals, including medical students, who were more exposed to pandemic-related stressors. However, health anxiety within this vulnerable group remains understudied.

Objective: This study aimed to assess and compare health anxiety and COVID-19 anxiety between medical and non-medical students during the COVID-19 pandemic and to identify factors associated with these forms of anxiety.

The survey of the status of self-stigma of depression and its relationship with demographic factors in Gonabad, Iran.

Introduction: Depression is a common mental illness. Depression stigma can reduce individuals' desire to seek mental health services. No study has investigated depression self-stigma and its relationship with demographic factors in the general population of Gonabad city in Iran.

Cold plasma technology: A cutting-edge approach for enhancing shrimp preservation.

Cold plasma (CP) is an emerging technology employed to safeguard highly perishable food items, particularly aquatic products such as shrimp. Due to its significant amount of moisture, superior protein composition that contains important amino acids, and unsaturated fatty acid content, shrimp are susceptible to microbial deterioration and overall alterations in their physical and chemical characteristics. Such spoilage not only diminishes the nutritional value of shrimp but also has the potential to generate harmful substances, rendering it unsuitable for consumption.

Efficacy of Surgery-First Approach in the Management of Severe Skeletal Class III Malocclusion: A Case Report.

The surgery-first approach (SFA) is gaining popularity in orthognathic surgery because it makes treatment duration shorter and more satisfying for patients. However, its effectiveness in complex cases isn't fully understood. Here, we describe a rare case where SFA was used to fix problems caused by missing posterior teeth and a deep bite, which made traditional pre-surgery orthodontic treatment impractical.

An Open Source Framework for Free Precise Digital Facial Analysis.

In the dynamic landscape of digital healthcare and facial aesthetics, there is a rising demand for tools combining precision and accessibility. This article explores an innovative approach emphasizing accuracy and accessibility in facial aesthetic procedures through individualized planning and open-source software utilization. Digital facial analysis was conducted using facial photogrammetry capturing 16 simultaneous images in 0.

Does Collagen Membrane Coverage Offer any Advantage for Lateral Window Sinus Augmentation? A Histologic and Histomorphometric Analysis.

Background: We aimed to determine whether collagen membrane coverage in maxillary sinus floor elevation surgery, provides an advantage regarding bone regeneration.

Methods: This randomized clinical trial included all healthy adults presented for dental implant placement in the posterior edentulous maxilla at the Maxillofacial Surgery Department of Mashhad Dental School, Mashhad, Iran from 2021-2022. Participants were candidates for sinus floor elevation surgery.

Intermaxillary Fixation Screws (IMF) & Surgery First Approach: A Novel Combination and Case Report.

Orthognathic surgery, a pivotal treatment for patients with significant facial aesthetic and occlusal concerns, traditionally involves a phased approach comprising preoperative orthodontics, surgery, and postoperative orthodontic treatment. However, the extended duration of conventional methods often leads to patient dissatisfaction. In response, the surgery-first approach (SFA) has emerged as an alternative, aiming to streamline treatment and reduce complexity.

Oral administration of crocin reverses memory loss induced by ethanol and nicotine abstinence in adolescent male rats.

Purpose: Regarding a wide variety of researches conducted with various therapeutic effect of crocin, the main constituent of saffron, the current study aims to assess the efficacy of crocin to improve learning and memory impairment caused by withdrawal following concurrent usage of ethanol (Eth) and nicotine (Nic) in adolescent male rats.

Methods: In order to test memory fucntion, Morris water maze and passive avoidance methods were applied in male Wistar rats undergone adolescent Nic-Eth withdrawal and the effect of crocin treatment was assessed at both behavioral and biochemical levels. The biochemical parameters included the inflammatory cytokines, indicators of oxidative stress and cholinergic metabolism within the hippocampla tissues.

Seasonal Trends and Emergency Admissions for Obstetric Hemorrhage and Trauma among Pregnant Women in Iran.

Objective: Globally, obstetric hemorrhage and trauma are the leading causes of maternal and fetal morbidity and mortality during pregnancy. Delivering high-quality medical care to these patients is therefore imperative.This study aims to examine the relationship between month of referral and the severity of emergency admissions among pregnant women referred for obstetric hemorrhage and trauma.

The impact of patient communication software app on facilitating communication with mechanically ventilated patients: A randomized clinical trial.

Background & Aim: The use of mechanical ventilation devices as a supportive respiratory system for hospitalized patients in intensive care units is often accompanied by the inability of alert patients to establish verbal communication. This study aims to determine the impact of patient communication software on facilitating communication for mechanically ventilated patients in the intensive care unit.

Methodology: This clinical trial was conducted with two groups, each comprising 60 alert, mechanically ventilated patients hospitalized in medical universities in Mashhad, from December 2022 to January 2023.

Assessment of binding affinity of major bioactive compounds from , , , , and to COX-2 receptor: an study.

In traditional medicine, potential anti-inflammatory and pain-relieving activity of and has been emphasized. In this study, we explored binding affinity of 36 bioactive compounds from these plants to cyclooxygenase-2 (COX-2) receptor using docking method. Six compounds namely, beta carotene, lycopene, lutein, momordicoside, rutin and azadirachtin showed excellent binding affinities (-10.

The Utility of Total Thrombus-Formation Analysis System (T-TAS) in the Thrombosis and Hemostasis Field: A Scoping Review.

Background: A wide variety of laboratory hemostasis tests is available, but the majority is plasma-based, static and unable to assess platelet function and fibrin formation simultaneously. The Total Thrombus-Formation Analysis System (T-TAS) is a microchip-based flow chamber system that simulates in vivo conditions for evaluating whole blood thrombogenicity.

Aim: A comprehensive overview of its applicability in different thrombosis and hemostasis related clinical situations is lacking and therefore this scoping review was performed.

Aspartame subacute exposure does not affect immune system of BALB/c mice following a tiered approach.

Background: The objective of the present study was to assess potential immunotoxic effects of aspartame in BALB/c mice.

Methods: Aspartame was administered orally at 400 and 2000 mg/kg for two weeks (five days per week). Specific parameters of humoral and cellular immune responses including hemagglutinating antibody (HA) titer, cytokine production (IFN-γ and IL-4 levels), delayed type hypersensitivity (DTH) response to SRBCs, histopathological examination of spleen and bone marrow, and T-lymphocyte proliferation in response to phytohemagglutinin-A (PHA) were evaluated.

Conservative Management of Horizontal Root Fracture: A Case Report.

In cases where permanent teeth have closed apices and completely erupted roots, the probability of root fractures is increased due to the stable support given by the adjacent bone and periodontal tissues. Fractures have the potential to affect several dental structures, including the pulp, dentin, cementum, bone, and periodontal tissues. In cases of horizontal root fractures (HRF), the apical section typically maintains vitality; however, the present case presented an unusual apex necrosis.

Animal origins free products in cell culture media: a new frontier.

Despite the importance of finding replacements for fetal bovine serum (FBS), very few studies have focused on this subject. Historically, the use of animals and their derivatives in growth, reproduction, and physiological studies has raised several concerns. The supplementation of culture media with FBS, also known as fetal calf serum, continues to be widespread, despite its limitations in quality, reproducibility, and implications for animal welfare.