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Oropharyngeal squamous cell carcinoma treatment: current standards and future directions.

Curr Opin Oncol

May 2014

aJohns Hopkins University, School of Medicine, Baltimore, Maryland bFox Chase Cancer Center, Philadelphia, Pennsylvania, USA.

Article Synopsis
  • The review focuses on the evolving diagnosis and treatment of oropharyngeal squamous cell carcinoma, particularly emphasizing the role of high-risk human papilloma viruses (HPVs) as key factors in the disease.
  • Recent studies show that HPV-positive tumors have better treatment responses and outcomes compared to HPV-negative ones, and they allow for patient stratification based on factors like HPV status and smoking history to assess risks.
  • Current research is exploring ways to reduce treatment intensity for low-risk groups, while highlighting the need for new therapies for patients with poorer prognoses linked to smoking and advanced disease stages.
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