6 results match your criteria: "Martin-Luther-University Halle-Wittenberg (Head: Prof. Dr. Dr. A.W. Eckert)[Affiliation]"

Background: The emotional impact on parents at the birth of their new-born with cleft lip and/or palate (CL/P) can be traumatic for parents, especially mothers, and affect the sensitive early parent-child relationship. Unlike many other congenital malformations facial deformities are visible to all. The uncommon facial appearance creates feelings and reactions in the mother, families and other people.

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Unlabelled: The aim of the study was to describe the attractiveness of a newborn with CL/P and the maternal reaction in relation to the child. Another purpose was to explore and describe the experience and subjectively perceived reaction of the mother and the social environment to the child before and after cleft lip surgery.

Material And Methods: A study to describe and evaluate mothers' experiences, feelings and emotions (n = 84) regarding having a child with CL/P was performed.

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Objectives: This study describes a modified method for secondary correction of whistling deformities in patients with unilateral and bilateral cleft lip/palate (CL/P), using a horizontal double transposition vermilion flap, including parts of the orbicularis oris muscle. The pre- and postoperative results were objectively evaluated.

Study Design: 34 patients with a whistling deformity who underwent secondary reconstruction between 07/2013 and 11/2018 were included in this study (mean age 20.

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New molecular aspects in the mechanism of oromaxillofacial cleft prevention by B-vitamins.

J Craniomaxillofac Surg

December 2018

Department of Oral and Maxillofacial and Facial Plastic Surgery, Martin-Luther-University Halle-Wittenberg (Head: apl. Prof. Dr. Dr. A.W. Eckert), Ernst-Grube-Straße 40, 06120, Halle, Germany.

Clinical and experimental studies show a clear positive effect of B-vitamins in the prevention of oromaxillofacial clefts, especially cleft lip and palate (CL/P). Hereby the local effect of thiamin (B1) in the amniotic fluid is very important for the embryonic facial development as seen in palatal organ models stimulated by topical B-vitamin application (Scheller et al., 2013a).

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Article Synopsis
  • Cleft lip and palate (CL/P) are common birth defects, and high-dose vitamin B supplementation during early pregnancy may reduce their occurrence, particularly in at-risk families. This study focused on the impact of thiamine (vitamin B1) on CL/P in genetically modified mice.
  • Twenty-four A/WySn female mice received high doses of thiamine at various pregnancy stages, with the study analyzing abortion rates and CL/P in offspring, alongside serum and amniotic fluid thiamine concentrations.
  • Results indicated that while thiamine did not reduce CL/P occurrences, its timing of supplementation affected outcomes, noting a decrease in abortions and changes in receptor expression related to clefts, highlighting the
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Purpose: Cleft lip and/or palate (CL/P) shows a gender-related distribution in human beings. The reason is unknown. This study analyzed the gender-related cleft appearance with respect to teratogenically and genetically determined cleft appearance and the response to thiamine (vitamin B1) supplementation.

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