13 results match your criteria: "Marshfield Clinic Research Institute. Marshfield[Affiliation]"
Article Synopsis
- In patients with atherosclerotic cardiovascular disease, increased age is linked to higher risks of both ischemic and bleeding events, prompting a study on the effect of aspirin dosage based on age.
- The ADAPTABLE trial involved nearly 15,100 participants who were randomly assigned to take either 81 mg or 325 mg of aspirin daily, with outcomes measured over an average follow-up of 26.2 months.
- Results indicated that age did not significantly affect how aspirin dosage influenced clinical outcomes, suggesting that both doses are similarly effective for elderly and younger patients in preventing cardiovascular events.
Detection of Blastomyces gilchristii via metagenomic sequencing in outbreak-associated soils.
Med Mycol
January 2024
Integrated Research and Development Laboratory, Marshfield Clinic Research Institute. Marshfield, WI, USA.
Article Synopsis
- Blastomycosis is a serious fungal infection that's mainly found in North America, occurring sporadically or during outbreaks.
- This study introduces a method for detecting the fungus Blastomyces in soil samples from a 2015 outbreak in Wisconsin using metagenomic sequencing.
- The research suggests optimized sequencing depth to effectively identify the fungus, aiding in pinpointing outbreak sources and understanding the ecology of Blastomyces.
Article Synopsis
- Internet-based participation in clinical trials can improve diversity and relevance, but there are key differences between internet and noninternet participants, particularly in demographics and health status.
- In the ADAPTABLE study, noninternet participants were generally older, more likely to be female, and had higher rates of comorbid conditions, resulting in poorer health outcomes compared to internet participants.
- Noninternet participants also exhibited greater issues with medication adherence, suggesting that while noninternet options can enhance diversity in trials, strategies are needed to improve their retention and adherence rates.
Background: Patients are admitted to the hospital for respiratory illness at different stages of their disease course. It is important to appropriately analyse this heterogeneity in surveillance data to accurately measure disease severity among those hospitalized. The purpose of this study was to determine if unique baseline clusters of influenza patients exist and to examine the association between cluster membership and in-hospital outcomes.
View Article and Find Full Text PDFBackground: US recommendations for COVID-19 vaccine boosters have expanded in terms of age groups covered and numbers of doses recommended, whereas evolution of Omicron sublineages raises questions about ongoing vaccine effectiveness.
Methods: We estimated effectiveness of monovalent COVID-19 mRNA booster vaccination versus two-dose primary series during a period of Omicron variant virus circulation in a community cohort with active illness surveillance. Hazard ratios comparing SARS-CoV-2 infection between booster versus primary series vaccinated individuals were estimated using Cox proportional hazards models with time-varying booster status.
Background: The annual reappearance of respiratory viruses has been recognized for decades. COVID-19 mitigation measures taken during the pandemic were targeted at respiratory transmission and broadly impacted the burden of acute respiratory illnesses (ARIs).
Methods: We used the longitudinal Household Influenza Vaccine Evaluation (HIVE) cohort in southeast Michigan to characterize the circulation of respiratory viruses from March 1, 2020, to June 30, 2021, using RT-PCR of respiratory specimens collected at illness onset.
Article Synopsis
- A study estimated the effectiveness of two and three mRNA COVID-19 vaccine doses against symptomatic illness due to SARS-CoV-2 Delta and Omicron variants in adults seeking outpatient care between October 2021 and February 2022.
- The research involved 3,847 participants and found that vaccine effectiveness (VE) against symptoms was significantly higher for three doses compared to two doses, especially during the Delta variant period.
- The results indicated that the three-dose regimen offered substantial protection against symptomatic illness when the Omicron variant was predominant, reinforcing the recommendation for a third vaccine dose.
Targeting SHP2 sensitizes differentiated thyroid carcinoma to the MEK inhibitor.
Am J Cancer Res
January 2022
Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer Tianjin 300060, People's Republic of China.
Article Synopsis
- Pharmacologic targeting of the MAPK/ERK pathway in differentiated thyroid carcinoma (DTC) faces challenges due to adaptive resistance, which complicates treatment outcomes.
- Researchers established MEK inhibitor (MEKi)-resistant models showing that multiple receptor tyrosine kinases (RTKs) and SHP2 signaling pathways were activated in these resistant cells.
- The study found that blocking SHP2 increased the effectiveness of MEKi and that combining SHP2 inhibitors with MEKi significantly reduces the reactivation of the MAPK pathway, suggesting a new therapeutic approach for advanced DTC resistant to MEKi.
Objective: Obesity and chronic pain often co-occur and exert bidirectional influences on one another. How patients with obesity and chronic pain respond to weight loss treatments, however, remains unclear. This study evaluated body weight, physical activity, and diet outcomes in participants with and without chronic pain in a 2-year behavioral weight loss trial.
View Article and Find Full Text PDFFarmer Mental Health in the US Midwest: Key Informant Perspectives.
J Agromedicine
January 2022
School of Environment and Natural Resources, The Ohio State University, Wooster, Ohio, USA.
In this study, we seek to illuminate: (1) the ways farm service providers and mental health professionals understand the drivers of farm stress, (2) the strategies, challenges, and opportunities farm service providers and mental health professionals identify for supporting the mental health needs of farm families, and; (3) opportunities for future research and outreach to improve the mental health of farmers in the U.S. Midwest region.
View Article and Find Full Text PDFEffect of rs13181 and rs1799793 polymorphisms and environmental factors on the prognosis of patients with lung cancer.
Am J Transl Res
October 2020
Center of Physical Examination, Navy Military Medical University Affiliated Changhai Hospital Shanghai, China.
Purpose: The 5-year survival rate of patients with lung cancer in China is < 20%, and predicting their prognosis is difficult. Here, we investigated the association between two common non-synonymous single-nucleotide polymorphisms (SNPs) in the excision repair cross-complementing 2 () genes (rs13181 and rs1799793) and the prognosis of patients with lung cancer.
Methods: Genomic DNA was extracted from the blood samples of 839 patients with lung cancer and genotyped using the SNPscan technique.
Adult weight management across the community: population-level impact of the LOSE IT to WIN IT challenge.
Obes Sci Pract
April 2018
Children's Heart Link Minneapolis MN USA.
Objective: Excess body weight negatively impacts health, but there are few evaluations of low-intensity weight management challenge programs in defined populations. This study examined weight change in adults who participated in the LOSE IT to WIN IT (LIWI) health challenge in a US community. The community-level impact on body mass index was also explored.
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