The novel estrogen receptor beta agonist EGX358 and genotype influence memory, vasomotor, and anxiety outcomes in an Alzheimer's mouse model.

Introduction: Alzheimer's disease (AD) prevalence and severity are associated with increased age, female sex, and apolipoprotein E4 (APOE4) genotype. Although estrogen therapy (ET) effectively reduces symptoms of menopause including hot flashes and anxiety, and can reduce dementia risk, it is associated with increased risks of breast and uterine cancer due to estrogen receptor alpha (ERα)-mediated increases in cancer cell proliferation. Because ERβ activation reduces this cell proliferation, selective targeting of ERβ may provide a safer method of improving memory and reducing hot flashes in menopausal women, including those with AD.

Towards a liana plant functional type for vegetation models.

Lianas (woody climbers) are crucial components of tropical forests and they have been increasingly recognized to have profound effects on tropical forest carbon dynamics. Despite their importance, lianas' representation in vegetation models remains limited, partly due to the complexity of liana-tree dynamics and the diversity in liana life history strategies. This paper provides a comprehensive review of advances and challenges for mechanistically representing lianas in forest ecosystem models and a proposed path towards effectively representing lianas in these models.

Enhanced Vascularity in Gelatin Scaffolds via Copper-Doped Magnesium-Calcium Silicates Incorporation: and Insights.

Addressing a critical challenge in current tissue-engineering practices, this study aims to enhance vascularization in 3D porous scaffolds by incorporating bioceramics laden with pro-angiogenic ions. Specifically, freeze-dried gelatin-based scaffolds were infused with sol-gel-derived powders of Cu-doped akermanite (CaMgSi2O) and bredigite (CaMgSiO) at various concentrations (10, 20, and 30 wt%). The scaffolds were initially characterized for their structural integrity, biodegradability, swelling behavior, impact on physiological pH, and cytocompatibility with human umbilical vein endothelial cells (HUVECs).

Development and validation of an artificial intelligence system for surgical case length prediction.

Background: Accurate case length estimation is a vital part of optimizing operating room use; however, significant inaccuracies exist with current solutions. The purpose of this study was to develop and validate an artificial intelligence system for improved surgical case length prediction by applying natural language processing and machine-learning methods.

Methods: All inpatient elective surgical cases longer than 30 minutes completed between 2017 and 2023 at a single, quaternary care hospital were considered.

Age enterprising: "Old" age on the make in Ghana.

The Aging Enterprise was first coined by Carol Estes to critique the hegemony of a gerontological discourse and policy in the United States in the 1970s. These policy interventions seemed to be serving the needs of policy-makers and aging professionals, rather than those of older adults. More recently she wrote on how these interventions limited the possibilities of the gerontological imagination and focused attention on "old age" as a social problem.

Evaluating Surgical Approaches for Hemimandibular Hyperplasia Associated with Osteochondroma: A Systematic Literature Review.

: Hemimandibular hyperplasia (HH) associated with osteochondroma presents complex challenges in maxillofacial surgery, including facial asymmetry, occlusal instability, and temporomandibular joint (TMJ) dysfunction. Surgical interventions vary widely in approach and outcomes, underscoring the need for a systematic evaluation of effectiveness. This systematic review assesses the effectiveness of surgical approaches for managing HH associated with osteochondroma, focusing on techniques including condylectomy, orthognathic surgery, distraction osteogenesis, total joint replacement (TJR), and genioplasty.

Performance of artificial neural network compared to multi-linear regression in prediction of countermovement jump height.

Previous research has used primarily linear regression models to predict jump height and establish contributors of performance. The purpose of this study was to compare the performance of artificial neural network (ANN) and multi-linear regression (MLR) in prediction of countermovement jump (CMJ) height and investigating the contribution of kinematic variables to CMJ performance. Thirty-four healthy young male athletes performed a total of 204 CMJ while eight kinematic variables (the hip, knee, and ankle angles at the begging of the concentric phase of CMJ, the hip and knee take-off angles, and the shoulder, hip, and knee maximum angular velocities) were used as inputs to ANN and MLR to predict CMJ height.

Comparison of accuracy of different dental age estimation methods in Finnish and Turkish populations.

Objective: The aims of this study were to assess the accuracy of Cameriere's and Demirjian's methods in Finnish children, and compare the findings with those of the Turkish children according to dental age.

Material And Methods: Dental panoramic tomography (DPT) of children (482 Finnish, 423 Turkish) aged between 5 and 15 years were evaluated. Comparison of mean difference between estimated and chronological age was evaluated.

Purification and characterization of mitochondrial biotin-dependent carboxylases from native tissues.

Biotin-dependent carboxylases catalyze the MgATP- and bicarbonate-dependent carboxylation of various acceptor substrates through a two-step carboxylation reaction. Biotin-dependent carboxylases play an essential role in the metabolism of key biomolecules and, therefore, they are the subject of ongoing drug discovery efforts, as well as of studies seeking to better characterize their structure and function. It has been an ongoing challenge to obtain high yields of mammalian biotin-dependent carboxylases for in vitro experimentation; these enzymes have not been successfully purified when recombinantly expressed from a bacterial expression host and only low yields of these recombinant, vertebrate enzymes have been obtained through expression in cell culture systems.

A personalized periodontitis risk based on nonimage electronic dental records by machine learning.

Objective: This study aimed to develop a machine-learning (ML) model to predict the risk for Periodontal Disease (PD) based on nonimage electronic dental records (EDRs).

Methods: By using EDRs collected in the BigMouth repository, dental patients from the US were included. Patients were labeled as cases or controls, based on PD diagnosis, treatment and pocketing.

The association between vigour and flexibility with injury and alertness during shift work.

Models of shift work and health suggest that individual differences in circadian rhythm characteristics may moderate the relationship between night shift work and injury, but this argument has not been directly tested. In this study, we tested the efficacy of two circadian rhythm characteristics-vigour and flexibility-as moderators of the path between shift work and injury. In addition, we aimed to replicate the association between vigour, flexibility, and alertness by time of day, and the measurement properties of the Circadian Type Inventory.

Realtime and noninvasive assessment of endotracheal tube displacement using near-infrared and visible cameras.

Endotracheal tube (ETT) intubation is a medical procedure routinely used for achieving mechanical ventilation in critically ill patients. Appropriate ETT placement is crucial as undetected tube migration may cause multiple complications or even fatalities. Therefore, prompt detection of unplanned movement of the ETT and immediate action to restore proper placement are essential to ensure patient safety.

Nutrition Literacy, Neighborhood, and Diet.

Objective: This study examined the influence of nutrition literacy and neighborhood on diet quality within the Mexican-origin population residing in the United States, addressing a gap in existing literature that lacks focus on specific Latinx subgroups.

Design: This study used a descriptive, correlational design to examine the relationships between nutrition literacy, neighborhood ranking, and diet quality.

Sample: A total of 130 Mexican origin participants living in the United States completed all components of this study.

Cumulative effects of H and P on force and power of skeletal muscle fibres from young and older adults.

The cellular causes of the age-related loss in power output and increased fatigability are unresolved. We previously observed that the depressive effects of hydrogen (H) (pH 6.2) and inorganic phosphate (P) (30 mm) did not differ in muscle fibres from young and older men.

The MC4R agonist, setmelanotide, is associated with an improvement in hypercapnic chemosensitivity and weight loss in male mice.

Obesity increases the risk of respiratory diseases that reduce respiratory chemosensitivity, such as Obesity Hypoventilation Syndrome and sleep apnea. Recent evidence suggests that obesity-related changes in the brain, including alterations in melanocortin signaling via the melanocortin-4 receptor (MC4R), may underly altered chemosensitivity. Setmelanotide, an MC4R agonist, causes weight loss in both humans and animal models.

Stimulus Repetition and Sample Size Considerations in Item-Level Representational Similarity Analysis.

In studies using representational similarity analysis (RSA) of fMRI data, the reliability of the neural representational dissimilarity matrix (RDM) is a limiting factor in the ability to detect neural correlates of a model. A common strategy for boosting neural RDM reliability is to employ repeated presentations of the stimulus set across imaging runs or sessions. However, little is known about how the benefits of stimulus repetition are affected by repetition suppression, or how they compare with the benefits of increasing the number of participants.

Effect of the Proximity of Roots to the Cortical Plate and Inclination of Incisors on External Apical Root Resorption.

Background: External apical root resorption (EARR) is an unfavorable side effect of orthodontic treatment. Orthodontic treatment of patients with increased crowding could lead to the proclination of incisors and proximity of roots to the cortical plates.

Aims: The aim of this study was to evaluate the effects of the proximity of the labial and lingual cortical plates and the inclination of incisors on EARR.

Analysis of Multivariable Sensor Responses to Multi-Analyte Gas Samples in the Presence of Interferents and Humidity.

This work presents an adaptive sensor signal-processing approach to enable quantification, using a single gas sensor or a small sensor array, of multianalyte mixtures of aromatic hydrocarbons in the presence of various interferents and humidity for environmental-monitoring applications. Dynamic sensor responses are analyzed by extracting multivariable sensing parameters to provide necessary sensitivity and selectivity. This is achieved by integrating the Levenberg-Marquardt-modified, exponentially weighted, recursive-least-squares-estimation (LM-modified EW-RLSE) algorithm and principal-component analysis (PCA).