70 results match your criteria: "Marmara University Istanbul[Affiliation]"

Article Synopsis
  • The study investigates the biological properties and chemical profiles of chickweed extracts using various solvents and advanced techniques like UHPLC/MS/MS.
  • Twelve phenolic compounds, primarily flavonoids, were identified, with the water extract showing the best antioxidant capabilities and the ethyl acetate extract showing strong enzyme-inhibiting effects.
  • The findings suggest chickweed could be a valuable resource for developing products in the pharmaceutical, nutraceutical, and cosmeceutical sectors due to its significant cytotoxic effects and potential mechanisms of action against cancer-related targets.
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  • Lysozyme (L), particularly chicken egg white lysozyme (CEWL), is a key enzyme analyzed in this study for its interaction with tannic acid (TA), commonly used in food and beverage production.
  • The research employed methods like surface plasmon resonance, molecular docking, and molecular dynamics simulations to understand how L binds with TA, revealing an average binding energy of -7.52 kcal/mol for TA compared to known inhibitor NAG at -6.46 kcal/mol.
  • Findings showed that the binding interactions were primarily influenced by hydrophobic, van der Waals, and hydrogen bonds, with this work offering insights that could lead to advancements in food science and oral biology research.
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The aim of this study was to investigate the effects of acute anaerobic exercise on serum levels of adipokines Zinc-α2-glycoprotein (ZAG), apelin, and lipasin. Eighteen male athletes who actively played soccer and trained at least four days a week, with a mean age of 19.11 ± 2.

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Schizophrenia diagnosis based on diverse epoch size resting-state EEG using machine learning.

PeerJ Comput Sci

August 2024

Instituto de Telecomunicações, Escola Superior de Tecnologia e Gestão de Águeda, Universidade de Aveiro, Águeda, Portugal.

Article Synopsis
  • * This study introduces a novel method for classifying schizophrenia using EEG signals from the brain, with data collected from 28 subjects, analyzing brain activity across different frequency bands and applying various techniques to enhance signal clarity.
  • * The findings indicate that the Support Vector Machine (SVM) algorithm, particularly with Log Energy entropy features in a 1-second window, performed the best in classifying schizophrenia, highlighting the importance of feature selection in achieving accurate diagnoses.
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Ethanol has been widely used for the extraction of propolis. Due to its certain disadvantages, there has been an ongoing search to find alternative non-ethanolic extraction solvents. This study aimed to compare the phenolics, antioxidant, and antibacterial activity of propolis extracts prepared with 70% ethanol (EWE), propylene glycol (PGE), and L-arginine solution (BE).

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We developed a microchip device using surface acoustic waves (SAW) and sharp-edge glass microparticles to rapidly lyse low-level cell samples. This microchip features a 13-finger pair interdigital transducer (IDT) with a 30-degree focused angle, creating high-intensity acoustic beams converging 6 mm away at a 16 MHz frequency. Cell lysis is achieved through centrifugal forces acting on cells and glass particles within the focal area.

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Burden of prostate cancer in the Middle East: A comparative analysis based on global cancer observatory data.

Cancer Med

December 2023

Department of Radiation Oncology, Brigham and Women's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.

Background: Prostate cancer represents a significant global health issue, yet our understanding of its impact in the Middle East remains limited. This study aimed to assess the incidence and mortality of prostate cancer in the Middle East, and compare these rates to those in Europe and North America.

Materials And Methods: We utilized the 2020 Global Cancer Observatory data, compiling incidence and mortality rates of prostate cancer in 20 Middle Eastern countries.

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Intrusion detection systems (IDSs) analyze internet activities and traffic to detect potential attacks, thereby safeguarding computer systems. In this study, researchers focused on developing an advanced IDS that achieves high accuracy through the application of feature selection and ensemble learning methods. The utilization of the CIC-CSE-IDS2018 dataset for training and testing purposes adds relevance to the study.

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  • This study investigated the oral RSV fusion protein inhibitor AK0529 for treating infant patients hospitalized with respiratory syncytial virus (RSV) infection, as current therapies are ineffective.
  • In a Phase 2 trial, infants were given AK0529 or a placebo, with no significant safety issues reported and promising results showing reduced viral load and respiratory symptoms with the higher dose of AK0529.
  • Overall, AK0529 was well-tolerated and indicated a potential for effective treatment in reducing RSV-related morbidity in young children.
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Radiation therapy for prostate cancer in Syrian refugees: facing the need for change.

Front Public Health

August 2023

Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

Article Synopsis
  • The study looked at how radiation therapy was used for Syrian refugee patients with prostate cancer in Turkey.
  • Out of 137 patients, many had advanced cancer, and only a small number received another type of treatment called androgen deprivation therapy.
  • The results showed that a lot of patients missed their treatment appointments, and improvements are needed to help these patients get the care they need.
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Purpose: To evaluate color differences in repair of indirect ceramic and resin nanoceramic CAD/CAM blocks with two universal shade composites after different surface preparations.

Materials And Methods: 120 samples were prepared from IPS Empress and GC Cerasmart270 CAD/ CAM blocks and thermocycled (5000 cycles, 5°C-55°C). Initial colors of sample surfaces were measured using a spectrophotometer.

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Objective: Retinal structural changes which were investigated by optical coherence tomography (OCT) have been reported in schizophrenia. Since cognitive dysfunction is a core feature of schizophrenia, the correlations between retinal findings and cognitive functions of patients and their healthy siblings may provide insight into the pathophysiological processes of the disorder. We aimed to investigate the relationship between neuropsychiatric tests and retinal changes in schizophrenia patients and their healthy siblings.

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To compare the outcomes of using low-power (up to 30 W) high-power (up to 120 W) holmium lasers in retrograde intrarenal surgery (RIRS) in children and to analyze if lasering techniques and the use of access sheath have any influence on the outcomes. We retrospectively reviewed data from 9 centers of children who underwent RIRS with holmium laser for the treatment of kidney stones between January 2015 and December 2020. Patients were divided into two groups: high-power and low-power holmium laser.

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A 69-year-old man with a known history of gastric and prostate adenocarcinoma was referred to 68Ga-prostate-specific membrane antigen (PSMA) PET/CT for restaging due to biochemical recurrence of prostate cancer. 68Ga-PSMA PET/CT revealed tracer accumulation in the primary prostatic lesion, lymph node, bone metastases, and brain lesion, which was later confirmed on biopsy to be metastasis of gastric carcinoma. This case reminds us of the variable spectrum of 68Ga-PSMA uptake in prostatic and nonprostatic metastatic lesions, the potential pitfalls on PET/CT images in the workup of patients with concomitant malignancies.

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A 71-year-old man who was diagnosed with carotid body paraganglioma was referred to 68 Ga-DOTATATE PET/CT for primary evaluation, which revealed unknown bony metastasis with intense 68 Ga-DOTATATE uptake. Head and neck paragangliomas are rare neuroendocrine tumors, with a 10% of malignancy rate, and identification of metastatic sites is important in staging and prognosis of the disease. We aimed to highlight the impact of 68 Ga-DOTATATE PET/CT on patient management, especially for equivocal lesions, as in our case.

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Introduction: The Coronavirus Disease 2019 (COVID-19) outbreak has resulted in huge psychological distress, especially for people working under risky conditions, such as healthcare workers. We aimed to investigate the psychological challenges of Turkish healthcare workers during the outbreak and discuss the factors that increase their burden, including stigmatization.

Methods: A cross-sectional online survey composed of sociodemographic data, questions about perceived stigma, and concerns about working conditions was completed.

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Optical coherence tomography (OCT) is a non-invasive imaging technique that detects retinal changes reflecting neurodegeneration. In recent studies in patients with bipolar disorder (BD) abnormal OCT findings have shown. In this study, we aimed to investigate the retinal changes in BD patients and their healthy siblings (HS) by comparing them with the healthy control (HC) group and to explore these findings as potential endophenotype candidates.

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Aims: To evaluate the current management and survival of patients with left-sided infective endocarditis (IE) complicated by congestive heart failure (CHF) in the ESC-EORP European Endocarditis (EURO-ENDO) registry.

Methods And Results: Among the 3116 patients enrolled in this prospective registry, 2449 (mean age: 60 years, 69% male) with left-sided (native or prosthetic) IE were included in this study. Patients with CHF (n = 698, 28.

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Aim: The aim of our study is to examine whether differences in retinal structure may reflect endophenotypes for schizophrenia by comparing thicknesses of retinal layers between patients with schizophrenia, their unaffected siblings, and healthy control groups and investigating the relationship between OCT findings and disease parameters.

Material And Methods: 46 patients with schizophrenia, their 46 healthy siblings, and 46 age and gender-matched healthy controls were enrolled in the study and underwent spectral domain OCT (examinations to assess differences in peripapillary retinal nerve fiber layer (RNFL) thickness, ganglion cell layer (GCL)+ inner plexiform layer (IPL) thicknesses and macular volumes (MV) in both eyes). Clinical variables were also recorded in the patient group.

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Article Synopsis
  • The study explored the effectiveness of a novel sterilizable metal brush compared to other carriers for cryopreserving prepubertal testicular tissue.
  • The results indicated that the metal brush showed minimal cell damage and the highest viability rate of 91.6%, outperforming aluminum foil, metal wire, and high-security straw.
  • Findings suggest the metal brush is a promising option for improving the vitrification process in preserving testicular tissue for children undergoing gonadotoxic treatments.
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Objectives: International guidelines recommend additional salt supplementation during infancy in classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. The influence of corticoid medication and growth has not been assessed.

Aim: To investigate the current use of salt supplementation, fludrocortisone (FC) and hydrocortisone (HC) dosage as well as weight, height, BMI and blood pressure (BP) in CAH children aged 0-3 years.

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Environmentally friendly products are the need of the hour, particularly in this pandemic situation because synthetic products need such toxic chemicals for their formulation and finishing which are carcinogenic for the globe. The current study is the utilization of waste black tea leaf (BT)-based tannin brown natural colorant for silk dyeing using microwave treatment. Dye (tannin) has been isolated in various media before and after microwave treatment up to 6 min and applied at various conditions.

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  • Paroxysmal nocturnal hemoglobinuria (PNH) is a complex genetic disorder that can lead to serious complications like blood clots, and recent studies show positive results from a treatment called eculizumab.
  • In a study of 138 PNH patients treated with eculizumab in Turkey from 2008 to 2018, common symptoms included fatigue and hemoglobinuria, with significant improvements in hemoglobin and lactate dehydrogenase levels noted after seven months of therapy.
  • The findings suggest that eculizumab is effective and well-tolerated, with minimal serious adverse events reported among the patients.
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This study investigated the effect of the structured Neurodevelopmental Therapy Method-Bobath (NDT-B) approach on the feeding and swallowing activity of patients with cerebral palsy (CP) and feeding difficulties. In addition to feeding and oral motor intervention strategies (OMIS), and nutrition-related caregiver training (NRCT), and the NDT-B, which was structured to increase trunk and postural control, was added to the therapy program. Forty patients with CP, with a mean age of 3.

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