2 results match your criteria: "Marmara University Faculty of Arts and Science[Affiliation]"
Investigation of , and polymorphisms on 5-fluorouracil related toxicities in colorectal cancer.
Per Med
September 2022
Department of Molecular Biology, Marmara University Faculty of Arts and Science, Istanbul, 34722, Turkey.
To investigate the association of , and polymorphisms on 5-fluorouracil (5-FU) related toxicities and patient survival. A total of 103 colorectal cancer patients prescribed 5-FU were included in the study. Genotyping was conducted for several , and polymorphisms using a microarray analyzer.
View Article and Find Full Text PDFAssociation of PD-1 and PDL-1 gene polymorphisms with colorectal cancer risk and prognosis.
Mol Biol Rep
March 2022
Department of Molecular Biology, Marmara University Faculty of Arts and Science, Istanbul, Turkey.
Background: Programmed Cell Death-1 (PD-1) together with Programmed Death Ligand 1 (PDL-1) have crucial roles in anti-tumor immune response, cancer susceptibility and prognosis. Since PD-1 and PDL-1 have been considered as important genetic risk factors in cancer development and their functions can be affected by polymorphic sites, we investigated the effects of PD-1 rs2227981, rs2227982, rs36084323 and PDL-1 rs2282055, rs822336 gene polymorphisms on colorectal cancer (CRC) risk and prognosis in Turkish subjects.
Methods And Results: Our study group consisted of 5-FU or Capacitabine prescribed CRC diagnosed patients and healthy controls.