Polycystic ovary syndrome: Fertility, prenatal care, pregnancy, and postpartum care.

Polycystic ovary syndrome (PCOS) is a complex, heterogeneous reproductive endocrinopathy affecting 8% to 13% of women in their reproductive years. PCOS has a vast array of clinical manifestations, including metabolic complications, biochemical and phenotypical hyperandrogenism, menstrual cycle dysfunction, and anovulation resulting in infertility. Understanding the relationship of the disorder's pathophysiologic and clinical manifestations is key to successfully managing patients with PCOS.

Child and Adolescent Manganese Biomarkers and Adolescent Postural Balance in Marietta CARES Cohort Participants.

Background: Manganese (Mn) plays a significant role in both human health and global industries. Epidemiological studies of exposed populations demonstrate a dose-dependent association between Mn and neuromotor effects ranging from subclinical effects to a clinically defined syndrome. However, little is known about the relationship between early life Mn biomarkers and adolescent postural balance.

"Don't Walk in There": The Challenges Birthing Persons Face at the Clinic.

During the summer of 2021, the author spent a week at an abortion clinic in the southern United States with two of his undergraduate students. In this piece, he engages in autoethnography and writing as a therapeutic process to show how his experience with his students changed his outlook on what abortion clinic workers, volunteers, and birthing persons go through every day. What has been happening outside abortion clinics across the country for decades needs to stop, and as someone who was not well-informed or involved before his trip to the abortion clinic, the author encourages others like him to take action to support abortion clinics with their important mission to protect the healthcare rights of birthing persons.

Nanoscale reshaping of resonant dielectric microstructures by light-driven explosions.

Femtosecond-laser-assisted material restructuring employs extreme optical intensities to localize the ablation regions. To overcome the minimum feature size limit set by the wave nature of photons, there is a need for new approaches to tailored material processing at the nanoscale. Here, we report the formation of deeply-subwavelength features in silicon, enabled by localized laser-induced phase explosions in prefabricated silicon resonators.

Fostering leadership learning for applied problem-solving: Navigating the crossroads of the sustainable development goals and immersive experiential learning.

This paper highlights how immersive educational experiences can help students understand the United Nations' Sustainable Development Goals (SDGs) and their relation to leadership. The paper provides an example of how a carefully designed faculty-led program using original research can cultivate cross-cultural competencies and build student knowledge and skills to support sustainability. Educators can use this paper as a guide to other immersive experiences to address the SDGs while developing student leadership capacity.

Maximizing patient safety when prescribing opioids for pain management.

Cytochrome P450 enzyme metabolism is altered by environmental and genetic factors, which can affect the efficacy and safety of opioids. This article describes CYP polymorphisms and how pharmacogenetic testing could be used to help clinicians make safer decisions about opioid use in patients.

Plant traits poorly predict winner and loser shrub species in a warming tundra biome.

Climate change is leading to species redistributions. In the tundra biome, shrubs are generally expanding, but not all tundra shrub species will benefit from warming. Winner and loser species, and the characteristics that may determine success or failure, have not yet been fully identified.

Migrainous infarction: A serious complication of a common condition.

Migrainous infarction is a rare neurologic condition that stems from an ordinary migraine with aura, and can cause ischemic stroke in young women. The pathophysiology of migrainous infarction is not entirely understood. An aura that is similar to previous auras but lasts longer than 60 minutes, along with evidence of acute ischemia on MRI, are diagnostic of migrainous infarction.

A comparative investigation of integral- and separable-dimension stimulus-sorting behavior.

Studies focusing on unsupervised categorization and sorting behavior have traditionally identified and empirically isolated a few select strategies frequently employed by observers, one-dimensional (SD), family resemblance (FR), and exclusive-or (XOR). To date, these investigations have mostly involved creating sets of multidimensional stimuli that directly contrast utilization of these strategies coupled with task or stimulus property manipulations to see their effects on categorization and sorting behavior. Currently, we extend on this methodological approach by having observers sort integral-dimension stimuli for two recently developed constrained unsupervised categorization tasks employing three-dimensional Boolean category structures.

An overview of esophageal atresia and tracheoesophageal fistula.

Esophageal atresia and tracheoesophageal fistula are often-concomitant pathologies that primarily afflict neonates. The complications of these anomalies may lead to increased morbidity and mortality, and clinicians should be familiar with the diagnosis and management of these pathologies. Clinicians can improve patient outcomes by having a thorough understanding of the signs and symptoms, classification systems, diagnostic workup, and surgical intervention options for these patients.

Lymphadenopathy secondary to tattoo ink in a patient with a history of Hodgkin lymphoma.

The finding of lymphadenopathy on physical examination and radiographically can suggest a wide range of differential diagnoses for patients, including a benign inflammatory process, infection, or malignancy. This article describes a patient with a history of Hodgkin lymphoma who developed postremission left axillary lymphadenopathy caused by deposits of tattoo ink in the node.

Complications of a congenital iris cyst in a newborn.

Congenital iris cysts are a rare condition in infants that can lead to multiple complications. This report describes an infant born with an iris cyst who developed complications including secondary glaucoma, cataracts, and visual impairment, requiring management with multiple surgical interventions and medications.

Essential Thrombocythemia in a 15-Year-Old Female: Presentation, Workup, and Treatment Considerations in the Pediatric Population.

Essential thrombocythemia (ET) is a diagnosis most often seen in adults but can also present in children in rare cases. This article reviews the presentation, diagnosis, and treatment of ET in a 15-year-old female followed by a review of the literature regarding special considerations in the workup, diagnosis, treatment, and follow-up of ET in the pediatric population.

AERMOD modeling of ambient manganese for residents living near a ferromanganese refinery in Marietta, OH, USA.

Elevated exposure to ambient manganese (Mn) is associated with adverse health outcomes. In Marietta, Ohio, the primary source of ambient Mn exposure is from the longest operating ferromanganese refinery in North America. In this study, the US EPA air dispersion model, AERMOD, was used to estimate ambient air Mn levels near the refinery for the years 2008-2013.

Tuberous sclerosis complex: A multisystem disorder.

Tuberous sclerosis complex (TSC) is a genetic disorder that affects multiple organ systems but often goes unrecognized, and a delay in diagnosis can lead to multiple complications. Healthcare professionals should be educated on the many signs and symptoms associated with the disorder, know how to treat them symptomatically, and recommend routine screening to assess for complications. Correctly identifying, diagnosing, and treating TSC can give patients a better quality of life and prevent further complications associated with the disorder.

Rural Standards and the Quality Equation.

The article describes the barriers rural surgeons face when attempting to measure, analyze, and benchmark the quality and value of the care they provide for their patients. Examples of suboptimal care are presented as well as special geographic and resource-related circumstances for many of these disparities of care. The article includes in-depth descriptions of the American College of Surgeons (ACS) Optimal Resources for Surgical Quality and Safety Program and the ACS Rural Hospital Surgical Verification and Quality Improvement Program.

Fecal microbiota transplantation in the treatment of Crohn disease.

Fecal microbiota transplantation (FMT) is an alternative treatment option with minimal risk for patients with Crohn disease. This article explains FMT and how it effectively targets the gut microbiota changes associated with the pathogenesis of Crohn disease.

ACE inhibitor-induced angioedema causing small bowel obstruction.

Mucosal angioedema of the face, lips, tongue, and throat is a well-recognized adverse reaction to angiotensin-converting enzyme (ACE) inhibitors that is experienced by a minority of patients. Rarely, this angioedema can involve the small bowel, and patients commonly present with abdominal pain and small bowel obstruction. Due to the increasing number of patients being treated for hypertension, clinicians should consider the diagnosis of small bowel angioedema secondary to ACE inhibitor use in all patients with this presentation who are using this class of medications.

Context, structure, and informativeness judgments: An extensive empirical investigation.

We explored the nature of human informativeness judgments: namely, people's judgments about the quantity of information that object stimuli convey about the category of objects to which they belong. Informativeness judgments play a key role in everyday decision-making situations involving the selection of items from groups that best represent the "group as a whole." They also provide insight into the nature of prototype formation.

Hijab pin inhalation.

Foreign body aspiration can be an acute life-threatening emergency and, if left untreated, can result in severe complications. Among Muslim women, the hijab pin can be accidentally aspirated. The article describes standard management with rigid bronchoscopy and a new technique involving magnets.

Experimental Partitioning of Trace Elements into Schreibersite with Applications to IIG Iron Meteorites.

Some of the defining characteristics of the IIG iron meteorite group are their high bulk P contents and massive, coarse schreibersite, which have been calculated to make up roughly 11-14 wt% of each specimen. In this study, we produced two datasets to investigate the formation of schreibersites in IIG irons: measurements of trace elements in the IIG iron meteorite Twannberg and experimental determinations of trace element partitioning into schreibersite. The schreibersite-bearing experiments were conducted with schreibersite in equilibrium with a P-rich melt and with bulk Ni contents ranging from 0-40 wt%.

Political Science: Developing Effective Participants in the Democratic Process.

Democratic governance has been a central tenant of leadership development in U.S. political science departments.

A review of Ehlers-Danlos syndrome.

Ehlers-Danlos syndrome (EDS) describes a group of heritable disorders of connective tissue comprising mutations in the genes involved in the structure and/or biosynthesis of collagen. Thirteen EDS subtypes are recognized, with a wide degree of symptom overlap among subtypes and with other connective tissue disorders. The clinical hallmarks of EDS are tissue fragility, joint hypermobility, and skin hyperextensibility.

Declines in Religiosity Predict Increases in Violent Crime-but Not Among Countries With Relatively High Average IQ.

Many scholars have argued that religion reduces violent behavior within human social groups. Here, we tested whether intelligence moderates this relationship. We hypothesized that religion would have greater utility for regulating violent behavior among societies with relatively lower average IQs than among societies with relatively more cognitively gifted citizens.