Xenobiotics recovery from plasma using solid phase extraction with C-18 sorbent - The reasons of literature discrepancies.

Solid phase extraction (SPE) is one of the most popular methods of preparing plasma samples before determining the xenobiotics they contain. The present paper shows that the recovery degree of xenobiotics from plasma samples using SPE with C18 sorbent strongly depends on their storage time and temperature. While xenobiotics can be isolated and recovered in 100 % from fresh plasma samples under optimal conditions of the SPE procedure, their SPE recovery degree from stored plasma is lower.

Adsorption and wetting properties of biosurfactants, Trtions and their mixtures in aqueous and water-ethanol environment.

Adsorption of rhamnolipid (RL) and surfactin (SF) as well as their mixtures with Triton X-100 (TX100) and Triton X-165 (TX165) at the solution-air (S-A), PTFE (polytetrafluoroethylene)-S, PMMA (poly (methyl methacrylate))-S, Q (quartz)-S, PMMA-A, and Q-A as well as their wetting properties regarding the surface tension of the PTFE, PMMA and quartz and its components and parameters were discussed using the literature data. The mutual influence of biosurfactants and Tritons on the S-A, PMMA(quartz)-A and PTFE(PMMA, quartz)-S interfaces tensions was considered in terms of their adsorption at these interfaces for both aqueous and water-ethanol solutions of the biosurfactant mixtures with Tritons. For this purpose there were used different methods on the basis of which the S-A, PMMA(quartz)-A and PTFE(PMMA, quartz)-S interface tensions can be predicted and/or described in the function of concentration and composition of the mixtures.

Challenges ahead: Exploring external barriers to self-determination in individuals with intellectual disabilities.

The extent to which individuals with intellectual disabilities (ID) can exercise self-determination in their adult lives is largely influenced by various contextual factors, including their family environment, the institutions they interact with, and the legal and social conditions in which they function. In this study, we aimed to explore the lived experiences of people with ID in the context of the environmental challenges they face on the path to self-determination. To achieve this goal, we conducted an inclusive study involving co-researchers with ID.

Efficient Method of ()-Nicotine Synthesis.

Improved methods for the synthesis of nicotine are of great importance due to the wide range of applications of synthetic nicotine, which is free from contamination with nitrosamines. Herein, we present a four-step chemical synthesis of ()-nicotine, involving the reduction in myosmine, enantiomeric separation of nornicotine, and subsequent methylation of the appropriate enantiomer of nornicotine obtained. The reduction in myosmine was investigated using both electrochemical and chemical approaches, achieving up to 90% yields of pure nornicotine.

Potential Use of Exosomal Non-Coding MicroRNAs in Leukemia Therapy: A Systematic Review.

Leukemia is a heterogeneous group of hematological malignancies. Despite the enormous progress that has been made in the field of hemato-oncology in recent years, there are still many problems related to, among others, disease recurrence and drug resistance, which is why the search for ideal biomarkers with high clinical utility continues. Research shows that exosomes play a critical role in the biology of leukemia and are associated with the drug resistance, metastasis, and immune status of leukemias.

Negative Affect and Planning Ability in Preschool Children: A Mediation Model of Working Memory, Inhibition, and Cognitive Flexibility.

Past research in developmental psychology has revealed close links between affect and planning ability over the life-span. However, such links have rarely been studied in children from non-clinical samples. To address this gap, the present study investigates whether negative affect, understood as a temperamental trait, affects planning ability in 5-year-old children.

The Values-Based Psychopathology of Antoni Kępiński (1918-1972).

Background: The question of the role of personal values in the constitution of and recovery from mental illness is a divisive subject discussed in contemporary psychopathology. This article critically examines the psychopathological theories and contributions of Antoni Kępiński - a seminal yet internationally under-recognized Polish psychiatrist.

Summary: Drawing upon a multilayered framework incorporating biological, affective-emotional, and sociocultural dimensions, Kępiński posited mental disorders as disturbances in the energy and information metabolism with the environment leading to an increase in entropy.

Polymeric resins containing modified starch as environmentally friendly adsorbents for dyes and metal ions removal from wastewater.

Effective removal of organic and inorganic impurities by adsorption technique requires the preparation of new materials characterized by low production costs, significant sorption capacity, and reduced toxicity, derived from natural and renewable sources. To address these challenges, new adsorbents have been developed in the form of polymer microspheres based on ethylene glycol dimethacrylate (EGDMA) and vinyl acetate (VA) (EGDMA/VA) containing starch (St) modified with boric acid (B) and dodecyl-S-thiuronium dodecylthioacetate (DiTDTA) for the removal of dyes: C.I.

Ultra-Performance Liquid Chromatography and Mass Spectrometry Characterization, and Antioxidant, Protective, and Anti-Inflammatory Activity, of the Polyphenolic Fraction from .

is a valuable plant widely consumed worldwide and considered a rich source of polyphenols. This study examined the impact of the polyphenolic fraction isolated from basil (ObF) on human normal colon epithelial cells and human colorectal adenocarcinoma cells, evaluating its anti-inflammatory and protective activity against oxidative stress. The phytochemical characterization of the fraction was performed using ultra-performance liquid chromatography (UPLC) with a photodiode detector (DAD) and mass spectrometry (MS).

Attachment and Detachment of Oil Droplets on Solid Surfaces: Insights from Molecular Simulations.

The behavior of oil droplets at solid surfaces is a key aspect of oil production and environmental protection. In this paper, the mechanisms of attachment and detachment of oil aggregates are studied via molecular dynamics simulations. The influence of oil-surface interactions on the shape and structure of adsorbed clusters is discussed.

Biochar amendment affects the fate of phthalic acid esters in the soil-vegetable system.

Phthalates, e.g., esters of phthalic acid (PAEs), when used as plasticizers due to weak physical bonding with polymer matrix favoring leaching, are widely noted in the environment.

Synthesis and characterization of a crosslinked deacetylated chitin modified chicken bone waste-derived hydroxyapatite and TiO biocomposite for defluoridation of drinking water.

This work represents an innovative approach to the synthesis and characterization of a chitosan-based biocomposite for fluoride adsorption. The work involved the development of a biocomposite based on modified chicken bone waste-derived hydroxyapatite and TiO. The composite was characterized using scanning electron microscopy with Energy Dispersive X-ray analysis (SEM-EDX), X-ray diffraction (XRD), Fourier-transform infrared analysis (FTIR), thermal-gravimetric analysis (TGA), and X-ray photoelectron spectroscopy (XPS).

Hematologists' state of knowledge on practical aspects of hemophagocytic lymphohistiocytosis (HLH) in adult patients: A Young Hematologists' Club survey.

Background: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome with various etiologies. Its treatment is complicated by several important but not immediately obvious issues (e.g.

Porous Copolymers of 3-(Trimethoxysilyl)propyl Methacrylate with Trimethylpropane Trimethacrylate Preparation: Structural Characterization and Thermal Degradation.

Porous polymeric microspheres are among the most effective adsorbents. They can be synthesized from numerous monomers using different kinds of polymerization techniques with a broad selection of synthesis factors. The main goal of this study was to prepare copolymeric microspheres and establish the relationship between copolymerization parameters and the porosity and thermal stability of the newly synthesized materials.

Quantitative Study of Vitamin K in Plants by Pressurized Liquid Extraction and LC-MS/MS.

The health-promoting properties of vitamin K stimulate the growing interest in this compound, which translates into the development of new analytical methodologies for its determination. New, more efficient methods of its isolation are sought, paying increasingly more attention to the methods within currently available extraction techniques that, owing to the optimization of the process, not only increase the extraction efficiency but are also economical and environmentally friendly. This article proposes a procedure for the extraction and analysis of one of the vitamin K vitamers, i.

Fast, Simple, and Sensitive Voltammetric Measurements of Acyclovir in Real Samples via Boron-Doped Diamond Electrode.

The voltammetric acyclovir (ACV) trace-level determination procedure has been introduced. This is the first time that a commercially available boron-doped diamond electrode (BDDE) coupled with differential-pulse voltammetry (DPV) has been used for this purpose. The commercially available BDDE is characterized by a short response time, low background current, and very good analytical parameters of ACV determination.

Methylene Blue and Rhodamine B Dyes' Efficient Removal Using Biocarbons Developed from Waste.

The preparation of biocarbons from cellulose fibres utilised in the production of baby nappy mats (sourced from Feniks Recycling company, Poland) for the removal of methylene blue and rhodamine B dyes has been documented. A Brunauer, Emmett and Teller analysis revealed a surface area within the range of 384 to 450 m/g. The objective of this study was to investigate the removal efficiency of dyes from aqueous solutions by biocarbons, with a particular focus on the influence of various parameters, including pH, dye concentration, adsorbent dosage, shaking speed, contact time, and temperature.

Hydrogen Production from Methanol Steam Reforming over Fe-Modified Cu/CeO Catalysts.

Fe-modified Cu catalysts with CeO support, prepared by the impregnation method, were subjected to physicochemical analysis and catalytic tests in the steam reforming of methanol (SRM). Physicochemical studies of the catalysts were carried out using the XRF, TEM, STEM-EDS, XRD, TPR and nitrogen adsorption/desorption methods. XRD, TEM studies and catalytic tests of the catalysts were carried out at two reduction temperatures, 260 °C and 400 °C, to determine the relationship between the form and oxidation state of the active phase of the catalysts and the catalytic properties of these systems in the SRM.

Antioxidant Properties of Green Plants with Different Vitamin K Contents.

Vitamin K, as a natural protector of our blood, bones, kidneys, and brain, is essential for human health. It is also considered an effective anti-aging agent with comprehensive biological effects, including antifungal, antibacterial, anti-inflammatory, analgesic, and even antioxidant properties. Of these, the least is known about the antioxidant properties of natural vitamin K.

The Comparison of Catalytic Activity of Carbimazole and Methimazole on Electroreduction of Zinc (II) in Chlorates (VII): Experimental and Molecular Modelling Study.

With the help of electrochemical methods, including CV and EIS, the influence of methimazole, carbimazole, and the concentration of the supporting electrolyte on the kinetics and mechanism of zinc electroreduction on a mercury electrode was compared and analyzed. Moreover, molecular dynamics simulations of zinc/carbimazole and zinc/methimazole solutions were carried out to determine the effect of drugs on the hydration sphere of Zn ions. It was shown that the electroreduction of Zn in the presence of methimazole and carbimazole occurs in two steps and the first one determines the kinetics of the entire process.

Transdiagnostic Assessment of Temporal Experience (TATE) in Mental Disorders-Empirical Validation and Adaptation of a Structured Phenomenological Interview.

Abnormal experiences of time (ATEs) are an established object of research in phenomenological psychopathology. The purpose of this study was the first validation of the Transdiagnostic Assessment of Temporal Experience (TATE), a structured phenomenological interview concerning ATEs in individuals with diverse mental health conditions, and its adaptation for the Polish language. The research employed a mixed-method approach and consisted of several phases including (1) consensual translation; (2) construct and content validation by an expert panel; (3) direct feedback from patients with lived experiences of alcohol addiction, borderline personality, autism, and clinical depression; (4) an auditorium questionnaire with 98 respondents without mental health issues, who were both interviewed and gave qualitative feedback; and (5) a final expert panel and approval.

From Waste to Water Purification: Textile-Derived Sorbents for Pharmaceutical Removal.

The presence of pharmaceuticals or their active metabolites in receiving waters is a sign of the inefficient removal of bioactive substrates from wastewater. Adsorption seems to be the most effective and inexpensive method of their removal. Waste management aimed at sorbents is a promising way to sustain several sustainable development goals.

Gene Fusions-What Promise Remains Behind These Rare Genetic Alterations? A Comprehensive Review of Biology, Diagnostic Approaches, and Clinical Implications.

Non-small cell lung cancer (NSCLC) presents a variety of druggable genetic alterations that revolutionized the treatment approaches. However, identifying new alterations may broaden the group of patients benefitting from such novel treatment options. Recently, the interest focused on the neuregulin-1 gene (), whose fusions may have become a potential predictive factor.

First voltammetric analysis of two possible anticancer drug candidates using an unmodified glassy carbon electrode.

Dimethyl 2-[2-(1-phenyl-4,5-dihydro-1H-imidazol-2-yl)hydrazinylidene]butanedioate (DIHB) and 8-(3-chlorophenyl)-2,6,7,8-tetrahydroimidazo[2,1-c][1,2,4]triazine-3,4-dione (HDIT) are promising candidates for anticancer agents, the first analytical procedures of which are presented in this paper. The commercially available unmodified glassy carbon electrode (GCE) was used as a sensor for the individual and simultaneous differential pulse voltammetric (DPV) determination of these possible anticancer drugs. The findings concerning the electrochemical behaviour indicated that DIHB and HDIT display at GCE, as a sensor, the oxidation peaks at 1.

Increased oxygen content in biochar lowered bioavailability of polycyclic aromatic hydrocarbons-related toxicity to various organisms.

Agricultural or environmental application of biochar (BC) is connected with the introduction of biochar-derived components among which polycyclic aromatic hydrocarbons (PAHs) and heavy metals are the most toxic. Their presence and bioavailability are crucial considering biochar toxicity. The effect of feedstock and pyrolysis temperature on the physicochemical properties of produced biochar and contaminant content was established and combined with toxicity to a broad range of living organisms.