322 results match your criteria: "Marcus Autism Center.[Affiliation]"

Disparities in autism research and practices based on race and ethnicity are evident across many outcomes and life course stages. However, most of the research has focused on outlining differences and not the underlying systemic inequities driving these disparities. In this conceptual paper, we aim to shift the focus by outlining mechanisms of structural racism within the institutions of science, healthcare, and residential segregation and educational systems in the United States (U.

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Several studies have examined the prevalence of behavioral relapse among individuals with intellectual and developmental disabilities following common treatment challenges (context changes, schedule thinning). Most applied studies compare behavior during the treatment challenges with the maximum level of behavior from five preceding treatment sessions. This max-of-5 criterion could inadvertently capture behavior in transition during the preceding treatment phase, thereby underestimating the prevalence of relapse.

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Emergence of social phases in human movement.

Phys Rev E

October 2024

Department of Physics, University of Miami, Coral Gables, Florida 33146, USA.

Article Synopsis
  • - Recent studies on animal movements show different thermodynamic phases, but similar insights for human movement, especially at low speeds, are lacking.
  • - Using ultrawideband RFID technology, researchers gathered detailed movement data from children in various settings, identifying two unique phases: a gaslike phase of freedom and a liquid-vapor phase indicating small social group formations.
  • - The study introduces a statistical physics model that replicates these observed phases and suggests that UWB-RFID can also aid research in broader areas like animal behavior and human interactions in complex systems.
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The National Institute of Mental Health created the National Database for Autism Research (NDAR) to accelerate autism knowledge through data sharing and collaboration. However, our experience using NDAR reveals systematic challenges across several aspects of data submission, selection, management, and analysis that limit utility of this resource. We describe our NDAR experience in an ongoing project examining autism intervention outcomes among marginalized racial, ethnic, and gender groups.

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Auditory gating and its clinical correlates in adults with chronic tic disorder and neurotypical adults.

Clin Neurophysiol

December 2024

Department of Pediatrics, Marcus Autism Center, Emory University School of Medicine, 1920 Briarcliff Rd, NE, Atlanta, GA 30329, USA. Electronic address:

Article Synopsis
  • - Over 80% of adults with chronic tic disorder (CTD) show sensory over-responsivity (SOR), which is an increased sensitivity to normal sensory stimuli, potentially linked to sensory gating impairments.
  • - The study compared sensory gating in neurotypical adults and those with CTD using clinical assessments and EEG monitoring, finding that CTD adults had higher levels of SOR but no significant differences in key auditory gating measures.
  • - Results indicated that while there was a relationship between N100 gating and SOR, sensory gating impairments may not be the main cause of SOR in CTD, suggesting the need for more research on this relationship.
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Past research has identified that some individuals with intellectual and developmental disabilities who engage in target behavior (e.g., aggression, self-injury) maintained by negative reinforcement engage in the behavior to escape or avoid social interaction specifically (i.

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Measuring autism with the ADOS-2 using a bifactor model.

Autism Res

December 2024

Marcus Autism Center, School of Medicine, Emory University, Atlanta, Georgia, USA.

The measurement of autism characteristics can be challenging due to variability of social impairments and restricted and repetitive behaviors or interests (RRBs). Psychometrically strong measures such as the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) can improve our capacity for thorough autism assessment. The conceptualization of the ADOS-2 has been shaped by research exploring the structure of its items, which evaluate autism traits associated with social affect and RRBs.

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Acoustic features of vocalizations in typically developing and autistic infants in the first year.

Res Dev Disabil

November 2024

Spoken Communication Laboratory, Marcus Autism Center, Children's Healthcare of Atlanta, Atlanta, GA, USA; Department of Pediatrics, Emory School of Medicine, Atlanta, GA, USA.

Background: We describe acoustic patterns across the five most prominent vocal types in typically developing infants (TD) and compare them with patterns in infants who develop autism (ASD) or a developmental disability (DD) not related to autism. Infant-directed speech (IDS) is a potentially important influence on such vocal acoustic patterns. Both acoustic patterns and effects of IDS are important for understanding the earliest origins of communication disorders.

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Background: 3q29 deletion syndrome (3q29del) is a rare (~1:30 000) genomic disorder associated with a wide array of neurodevelopmental and psychiatric phenotypes. Prior work by our team identified clinically significant executive function (EF) deficits in 47% of individuals with 3q29del; however, the nuances of EF in this population have not been described.

Methods: We used the Behavior Rating Inventory of Executive Function (BRIEF) to perform the first in-depth assessment of real-world EF in a cohort of 32 individuals with 3q29del (62.

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The development and structure of the HEALthy Brain and Child Development (HBCD) Study EEG protocol.

Dev Cogn Neurosci

October 2024

Department of Human Development and Quantitative Methodology, The University of Maryland, College Park, USA.

The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally and planned through early childhood. Electroencephalography (EEG) is one of two brain imaging modalities central to the HBCD Study. EEG records electrical signals from the scalp that reflect electrical brain activity.

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Exploring the Congruence of actigraphy and the Pediatric Autism Insomnia rating Scale.

Sleep Med

November 2024

Emory University School of Medicine, Marcus Autism Center, 1920 Briarcliff Rd. NE, Atlanta, GA, 30033, USA. Electronic address:

Objective/background: Insomnia is common in children with autism spectrum disorder (ASD). We recently developed and validated the 21-item Pediatric Autism Insomnia Rating Scale (PAIRS). This report explores the associations and agreements between actigraphy and PAIRS.

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Background: The neurodiversity paradigm positions autism as a neurological difference that is disabling in the societal context, shifting away from the traditional medical view of a disorder. Several recent publications recommend use of alternative neuro-affirming language (ANL) instead of traditional medical language (TML) with the aim to increase acceptance of autistic people and reduce prejudice. Examining language use within recent autism literature, including by journal and study characteristics, may offer insight into the influence of these recommendations and current disability discourse.

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Article Synopsis
  • Insomnia is a common problem for kids with autism, making it hard for them to fall or stay asleep.
  • Researchers created a new tool called the Pediatric Autism Insomnia Rating Scale to help understand and measure sleep issues in autistic children, collecting data from 1185 kids.
  • The scale was tested and proved to accurately measure sleep problems, showing stable results over time, so it's a reliable way to assess insomnia in children with autism.
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Registering longitudinal infant brain images is challenging, as the infant brain undergoes rapid changes in size, shape and tissue contrast in the first months and years of life. Diffusion tensor images (DTI) have relatively consistent tissue properties over the course of infancy compared to commonly used T1 or T2-weighted images, presenting great potential for infant brain registration. Moreover, groupwise registration has been widely used in infant neuroimaging studies to reduce bias introduced by predefined atlases that may not be well representative of samples under study.

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Doctoral psychology internships play a key role in the development of the competencies of the clinical child and adolescent psychologist workforce needed to serve the increasing behavioral and mental health needs of children. This study surveyed 50 internship training directors regarding workforce needs, the structure of experiential internship components, and the organizational infrastructure and funding of internship programs that provide focused care to children and adolescents within medical settings. Findings suggest that internships most commonly occur within academic medical settings and include clinical child psychology, integrated care, pediatric psychology, neuropsychology, and developmental disabilities tracks.

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As infants develop, caregivers adjust their behaviour to scaffold their infant's emerging skills, such that changes in infants' social abilities are expected to elicit changes in caregiver behaviour. We examined whether changes in the probability of infant-directed caregiving behaviour-specifically, greeting, a ubiquitous signal used by caregivers to initiate reciprocal interactions-differ between infant-caregiver dyads with an infant later diagnosed with autism and dyads with a neurotypically developing infant during infants' first 6 months. Using longitudinal data from 163 dyads, we found that caregivers in autism dyads ( = 40) used greeting less and at later infant ages than caregivers with a neurotypically developing infant (neurotypical dyads, = 83).

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Infant vocal category exploration as a foundation for speech development.

PLoS One

May 2024

Origins of Language Laboratory, School of Communication Sciences and Disorders, University of Memphis, Memphis, Tennessee, United States of America.

Non-random exploration of infant speech-like vocalizations (e.g., squeals, growls, and vowel-like sounds or "vocants") is pivotal in speech development.

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Article Synopsis
  • Scientists studied a genetic change called 3q29 deletion (3q29Del) which greatly increases the risk for disorders like schizophrenia and autism.
  • They used brain scans to look at the cerebellum (part of the brain) in 24 people with 3q29Del and 1,608 people without, finding that those with the deletion had smaller cerebellum areas and other differences.
  • The research suggests that problems in the cerebellum might be linked to how people with 3q29Del think and move, helping us understand brain issues better in these disorders.
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We assessed whether novel praise statements could be used to (a) maintain and increase responses with existing reinforcement histories and (b) teach a previously untaught response among children diagnosed with autism spectrum disorder across two experiments. During response-stimulus pairing, two responses resulted in preferred edibles but only one also produced a praise statement. In the absence of edibles, the response continuing to produce praise tended to persist more.

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The 3q29 deletion (3q29Del) is a copy number variant (CNV) with one of the highest effect sizes for psychosis-risk (>40-fold). Systematic research offers avenues for elucidating mechanism; however, compared to CNVs like 22q11.2Del, 3q29Del remains understudied.

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Clinical Correlates and Prevalence of Food Selectivity in Children with Autism Spectrum Disorder.

J Pediatr

June 2024

Department of Pediatrics, Emory University School of Medicine, Marcus Autism Center, Children's Healthcare of Atlanta, Atlanta, GA.

Objective: To examine clinical correlates and prevalence of food selectivity (FS) - ie, self-restricted diet, reluctance to try new foods - in children with autism spectrum disorder (ASD) ascertained from a general outpatient autism clinic.

Study Design: A multidisciplinary team (pediatric nurse practitioner, psychologist and dietitian) assessed medical and psychosocial histories and dietary habits in 103 children with ASD (mean age = 5.8 ± 2.

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Functional communication training (FCT) is an evidence-based treatment for behavior targeted for reduction that often combines extinction for target responses and arranges functionally equivalent reinforcement for alternative behavior. Long-term effectiveness of FCT can become compromised when transitioning from clinic to nonclinic contexts or thinning reinforcement schedules for appropriate behavior. Such increases in targeted behavior have been conceptualized as renewal and resurgence, respectively.

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Part C Early Intervention (EI) systems are an entry point to services for autistic toddlers and can be leveraged to facilitate access to autism evidence-based practices (EBPs). However, EI systems are complex and limited research has examined how an EI system's infrastructure (i.e.

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