346 results match your criteria: "Marchiafava-Bignami Disease"

Mutism Caused by Severe Demyelination in a Patient With Marchiafava-Bignami Disease.

J Emerg Med

December 2016

Yale New Haven Hospital, Yale School of Medicine, New Haven, Connecticut; David Geffen School of Medicine at UCLA, Los Angeles, California.

Background: Marchiafava-Bignami (MB) disease is a rare disorder that causes primary degeneration of the corpus callosum. It is associated with chronic alcohol consumption caused by either a toxic or nutritional etiology.

Case Report: We report a case of a 54-year-old woman who presented to our emergency department with complete mutism caused by MB disease that completely resolved with intravenous thiamine and dextrose therapy.

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Marchiafava-Bignami disease in chronic alcoholic patient.

Radiol Case Rep

September 2016

Radiology Department, Medical College Baroda, SSG Hospital, Vadodara, Gujarat, India.

Marchiafava-Bignami disease is a rare toxic encephalopathy seen mostly in chronic alcoholics due to progressive demyelination and necrosis of the corpus callosum. It may involve adjacent white matter and subcortical regions. We present here the magnetic resonance imaging findings of Machiafava-Bignami disease in a chronic alcoholic patient.

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Vegetarian diet and excessive tea consumption: a dangerous association?

Metab Brain Dis

February 2017

Unit of Neurology, Ospedale Bolognini, Seriate, BG, Italy.

Rare metabolic diseases may sometimes arise acutely and endanger human life if not immediately recognized and treated. Marchiafava Bignami disease is an uncommon neurologic disorder described in alcohol abusers and characterized by an acute severe damage of brain white matter. Even more rarely, it has been reported in non-alcohol addicted patients, but never in vegetarian people.

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[Marchiafava-Bignami disease (Case-report)].

Neuropsychopharmacol Hung

June 2016

MH EK Honvédkórház, Pszichiátriai osztály, Budapest, Hungary.

Marchiafava-Bignami disease (MBD) is caused by damage of the corpus callosum. There are acute, subacute and chronic forms, it occurs most frequently among alcoholic patients. A variety of neurological symptoms, epileptic seizures, and coma may be associated with the disease, but the chronic form may start with acute confusion and dementia, interhemispherial disconnection syndrome or with slow progressive changes in behavior.

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Aims: To describe the case and management of a patient with Marchiafava-Bignami Disease (MBD) with frontal cortical lesions, no specific symptom at first referral to the Emergency Room, and late onset of atypical psychiatric symptoms.

Methods: We report the case of a 44-year-old patient with a history of chronic alcohol abuse, eventually diagnosed with MBD.

Results: Magnetic Resonance showed lesions in the splenium and the body of corpus callosum and bilateral lesions of the frontal cortex.

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Marchiafava - Bignami disease is rare sequelae of chronic alcohol use. We present a case with transient ischemic attack like presentation and its management with parenteral thiamine. A 53 year old male with history of country liquor use since 32 years was brought to hospital with acute onset of delirium & mild weakness involving motor functions of left side of the body, non-reactive planters and exaggerated tendon reflexes on left side.

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A 61-year-old alcoholic man was admitted to our hospital because of disturbance of consciousness. He also exhibited external ophthalmoplegia, diplopia and mild rigidity, but tendon reflex was normal. On brain MRI, diffusion weighted images (DWI) and apparent diffusion coefficient (ADC) map depicted high intensity in the splenium of the corpus callosum.

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Neurologic Manifestations of Chronic Liver Disease and Liver Cirrhosis.

Curr Probl Diagn Radiol

May 2016

Department of Radiology/Interventional Radiology, Institute of Liver and Biliary Sciences, D-1, Vasant Kunj, New Delhi, India. Electronic address:

The normal functioning of brain is intimately as well as intricately interrelated with normal functioning of the liver. Liver plays a critical role of not only providing vital nutrients to the brain but also of detoxifying the splanchnic blood. Compromised liver function leads to insufficient detoxification thus allowing neurotoxins (such as ammonia, manganese, and other chemicals) to enter the cerebral circulation.

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In this presentation, I will examine the intricate systemic connections in the white matter and the disturbances that occur due to diseases. In particular, I will discuss Marchiafava-Bignami disease, leukodystrophy with neuroaxonal spheroids, and myotonic dystrophy. Investigation of all three diseases reveals the crosstalk essential for the healthy brain and the resulting dysfunctions that follow lesions of different etiologies.

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A male, 62-year-old patient was admitted to hospital due to dizziness and gait disturbance for 10 days. The patient had fallen a few times due to the gait instability, which was associated with stiffness and memory loss. The patient had undergone cardiac carcinoma surgery three years previously and had no drinking history.

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Teaching NeuroImages: Reversible widespread brain MRI lesions in Marchiafava-Bignami disease.

Neurology

March 2015

From the Clinic of Neurology (I.D., J. Dačković, S.M., J. Drulović) and MRI Centre (I.N.), Clinical Centre of Serbia, Belgrade; University of Belgrade School of Medicine (I.D., S.M., J. Drulović), Serbia; and County Hospital (M.G.-K.) Užice, Serbia.

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Marchiafava-Bignami disease (MBD) is a rare pathological condition affecting the corpus callosum (CC), characterized by progressive demyelination and necrosis. While usually found in patients with chronic alcoholism, it has rarely been characterized in non-alcoholics. We describe a trauma patient with an unknown mechanism of injury, who was found to have MBD after remaining comatose for a prolonged period of time.

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Marchiafava-Bignami disease is a rare alcohol-associated disorder. Clinical features include not only disturbed consciousness, dysarthria, tetraparesis, and astasia-abasia as initial symptom but also cognitive deficits and symptoms of interhemispheric disconnection as clinical outcomes. The clinical significance of cerebral microhemorrhage has been recognized in patients with cognitive deficits.

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Spinal anesthesia in a patient with Marchiafava-Bignami disease.

Can J Anaesth

May 2015

The Department of Anesthesiology and Perioperative Care, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada.

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Marchiafava-Bignami disease presenting as acute dysarthria and ataxia.

Alcohol Alcohol

March 2015

Department of Neurology, Mount Sinai Beth Israel, 10 Union Square East, New York, NY 10003, USA

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Chronic abuse of alcohol triggers different types of brain damage. The Wernicke-Korsakoff syndrome gets together Wernicke's encephalopathy and Korsakoff's syndrome. Another type of encephalopathy associated with chronic ethanol consumption is represented by the Marchiafava-Bignami malady or syndrome, an extremely rare neurological disorder, which is characterized by a demielinization of corpus callosum, extending as far as a necrosis.

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Structural and microstructral imaging of the brain in alcohol use disorders.

Handb Clin Neurol

July 2016

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA; Neuroscience Program, SRI International, Menlo Park, CA, USA. Electronic address:

Magnetic resonance imaging (MRI), by enabling rigorous in vivo study of the longitudinal, dynamic course of alcoholism through periods of drinking, sobriety, and relapse, has enabled characterization of the effects of chronic alcoholism on the brain in the human condition. Importantly, MRI has distinguished alcohol-related brain effects that are permanent versus those that are reversible with abstinence. In support of postmortem neuropathologic studies showing degeneration of white matter, MRI has shown a specific vulnerability of brain white matter to chronic alcohol exposure by demonstrating white-matter volume deficits, yet not leaving selective gray-matter structures unscathed.

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Molecular and neurologic responses to chronic alcohol use.

Handb Clin Neurol

July 2016

Virginia Commonwealth University Alcohol Research Center, Department of Pharmacology and Toxicology, Center for Study of Biological Complexity and Department of Neurology, Virginia Commonwealth University, Richmond, VA, USA. Electronic address:

This chapter provides an overview of current knowledge on the molecular and clinical aspects of chronic alcohol effects on the central nervous system. This drug is almost ubiquitous, widely enjoyed socially, but produces a diverse spectrum of neurologic disease when abused. Acutely, alcohol interacts predominantly with γ-aminobutyric acid-A (GABA-A) and N-methyl-d-aspartate (NMDA) receptors, but triggers diverse signaling events within well-defined neural pathways.

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